Active Recombinant Human FGF8 Protein, His-Tagged
Cat.No. : | FGF8-01H |
Product Overview : | Recombinant Human FGF8 Protein, His-Tagged was expressed in HEK293 cell |
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Description : | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Liquid |
Bio-activity : | Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells in the presence of 10 ug/ml of heparin. The ED50 range ≤ 5 ug/ml. |
Molecular Mass : | 23.7kDa (204aa) |
Protein length : | 204aa |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Storage : | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Absorbance at 280nm) |
Storage Buffer : | Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol. |
Gene Name : | FGF8 fibroblast growth factor 8 [ Homo sapiens (human) ] |
Official Symbol : | FGF8 |
Synonyms : | FGF8, AIGF, Androgen-induced growth factor, FGF-8, HBGF-8, Heparin-binding growth factor 8, HH6, KAL6,fibroblast growth factor 8, fibroblast growth factor 8 isoform B |
Gene ID : | 2253 |
mRNA Refseq : | NM_006119.6 |
Protein Refseq : | NP_006110.1 |
MIM : | 600483 |
UniProt ID : | P55075 |
Products Types
◆ Recombinant Protein | ||
FGF8-041H | Active Recombinant Human FGF8 Protein | +Inquiry |
FGF8-100H | Active Recombinant Human FGF8 Protein (Gln52-Arg223), C-His tagged, Animal-free, Carrier-free | +Inquiry |
FGF8-647H | Active Recombinant Human FGF8 Protein (Gln23-Arg215), Met | +Inquiry |
FGF8-12H | Active Recombinant Human FGF8 Protein, Animal Free | +Inquiry |
FGF8-1500H | Recombinant Human FGF8 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
FGF8-6234HCL | Recombinant Human FGF8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGF8 is essential for midbrain and limb bud patterning during embryonic development. Spatial and temporal expression is coordinated by signaling pathways and transcription factors that regulate FGF8 expression.
Post-translational modifications, including glycosylation, can influence FGF8 function. Glycosylation may modulate ligand-receptor interactions, affecting the specificity and strength of FGF8 signaling.
FGF8 is a member of the fibroblast growth factor family with a β-trefoil tertiary structure. This structure dictates its binding to FGF receptors and heparin sulfate proteoglycans, essential for signal transduction.
FGF8 engages in crosstalk with pathways like Wnt and Shh during tissue morphogenesis. This interaction influences organogenesis by coordinating cellular processes and ensuring proper tissue patterning.
FGF8 interacts with the extracellular matrix, affecting ligand stability and bioavailability. This interaction modulates FGF8 diffusion and gradients in the tissue microenvironment.
Customer Reviews (3)
Write a reviewTop-quality and timely delivery. It's a pleasure working with this product.
Service, quality, and shipping—all exceptional. This product is our research ally.
Seamless shipping and a product that never disappoints. Kudos!
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