furin
Share
  • Official Full Name
  • furin (paired basic amino acid cleaving enzyme)
  • Background
  • Proteins are normally synthesized in an inactive form and later require proteolytic processing to become active. Proprotein convertases make up a family of serine proteases capable of activating substrates that will subsequently intervene in extracellular
  • Synonyms
  • FURIN; furin (paired basic amino acid cleaving enzyme); FUR, PACE, paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein) , PCSK3; SPC1; FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furi
Cat.#:FURIN-605HTag:
Source (Host):Drosophila melanogaster Schneider 2 cellsSpecies:Human
Product nameRecombinant Human FURIN Protein
+Inquiry
Cat.#:FURIN-4553HTag:
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FURIN Protein
+Inquiry
Cat.#:FURIN-4554HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FURIN Protein, GST-tagged
+Inquiry
Cat.#:Furin-566MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Furin (paired basic amino acid cleaving enzyme)
+Inquiry
Cat.#:FURIN-755HTag:N/A
Source (Host):BSC-40 cellsSpecies:Human
Product nameRecombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)
+Inquiry
Cat.#:FURIN-13036HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FURIN, His-tagged
+Inquiry
Cat.#:FURIN-16HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human FURIN protein, His-tagged
+Inquiry
Cat.#:FURIN-17HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FURIN Protein, His-tagged
+Inquiry
Cat.#:FURIN-606HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human FURIN, His-tagged
+Inquiry
Cat.#:FURIN-720HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)
+Inquiry
Cat.#:FURIN-7820HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FURIN protein, His & GST-tagged
+Inquiry
Cat.#:FURIN-6087MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FURIN Protein
+Inquiry
Cat.#:Furin-7821MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Furin protein, His-tagged
+Inquiry
Cat.#:Furin-7822MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Furin protein, His & GST-tagged
+Inquiry
Cat.#:FURIN-2410RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FURIN Protein
+Inquiry
Cat.#:FURIN-1767RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FURIN Protein, His-tagged
+Inquiry
Cat.#:FURIN-6280CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FURIN
+Inquiry
Cat.#:FURIN-6119HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FURIN 293 Cell Lysate
+Inquiry

Involved Pathway

FURIN involved in several pathways and played different roles in them. We selected most pathways FURIN participated on our site, such as Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with FURIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Influenza A
IFNA21; OAS1A; EIF2AK4; KPNA1; IFNA12; HLA-DOA; ICAM1; IFNB1; IFNG; HSPA6

Protein Function

FURIN has several biochemical functions, for example, endopeptidase activity, metal ion binding, nerve growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FURIN itself. We selected most functions FURIN had, and list some proteins which have the same functions with FURIN. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein KLK1B5; PSMB4; APH1B; KLK1B22; HTRA3; PSMA6; SENP3; PSMB1; CASP1; ELANE
Function metal ion binding
Related Protein CYP2J6; ERCC5; PVALB5; HE2; NSF; TRIM35-34; WT1A; MAP3K4; OTUD7A; EME1
Function nerve growth factor binding
Related Protein FURIN; NTRK1; NGFR; PCSK6; NGFRB; SORT1
Function peptidase activity
Related Protein Shh; KLK1B9; ST14A; MASP1; SPCS1; PSD; HPN; MCPT8; ELA3L; CELA3B
Function peptide binding
Related Protein ANG; CALR; GNRHR; HCRTR2; NPFFR1L1; NPFFR1L3; FNTB; LNPEP; ERAP2; RPS6KB2
Function protease binding
Related Protein POLG; TNFAIP3; CD70; LCN2; ECM1; SERPINF2; Serpina1b; KIT; HSPD1; ITGA3
Function protein binding
Related Protein FZD2; ARHGDIA; GPSM3; ORC4L; RIMS1; GSDMA2; FANCB; RIMS2; EPB42; CHMP2A
Function serine-type endopeptidase activity
Related Protein ST14; TMPRSS11B; PROC; KLK4; TMPRSS11D; PLAU; PARL; RHBDD2; GZMB; HPN
Function serine-type endopeptidase inhibitor activity
Related Protein SERPINB6B; SERPINI1; SERPINB3C; GOPC; SERPINA1E; SPINK6; WFDC3; AMBP; SERPINB6; COL6A3

Interacting Protein

FURIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FURIN here. Most of them are supplied by our site. Hope this information will be useful for your research of FURIN.
MSTN; MST1R; DDX56; ABCC6; Gorasp2; BAG6; MMP14; HUWE1; Dennd6a; SGTB; TGOLN2; GORASP2; Spn42Da

FURIN Related Articles

Gierer, S; Muller, MA; et al. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. JOURNAL OF INFECTIOUS DISEASES 211:889-897(2015).
Pasetto, M; Antignani, A; et al. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1135-E1142(2015).