fus
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  • Official Full Name
  • fused in sarcoma
  • Background
  • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
  • Synonyms
  • FUS; fused in sarcoma; TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2; RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2;
Cat.#:FUS-4555HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FUS Protein, GST-tagged
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Cat.#:FUS-461HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUS Protein, His-tagged
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Cat.#:Fus-462MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fus Protein, His/GST-tagged
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Cat.#:FUS-13037HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUS, GST-tagged
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Cat.#:FUS-30143THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUS, His-tagged
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Cat.#:FUS-6088MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FUS Protein
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Cat.#:FUS-1121CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FUS
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Cat.#:FUS-11307ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FUS
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Cat.#:FUS-6118HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FUS 293 Cell Lysate
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Involved Pathway

FUS involved in several pathways and played different roles in them. We selected most pathways FUS participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
PROM1; RXRG; CD14; HIST2H3C1; FUT8; HIST1H3I; MYCN; REL; HIST1H3D; H3F3A

Protein Function

FUS has several biochemical functions, for example, DNA binding, RNA binding, estrogen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUS itself. We selected most functions FUS had, and list some proteins which have the same functions with FUS. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF32; HIST1H2BI; MAFBB; GTF2E2; SP110; RAD51L1; H2BFWT; ZNF652; ZNF276; DEAF1
Function RNA binding
Related Protein NOL3; RBM24A; LRPPRC; DZIP3; TRIM71; WRAP53; ADAT1; PUSL1; RPLP1; NHP2L1A
Function estrogen receptor binding
Related Protein CNOT1; TRIP4; NKX3; DDX5; TAF10; NCOA1; DYX1C1; PADI2; LEF1; WIPI1
Function identical protein binding
Related Protein ATL3; NIF3L1; RYR2; FHIT; MMP9; SAFB2; SH3GL1; IGF2R; LYZ2; ACTG1
Function ionotropic glutamate receptor binding
Related Protein FUS; SHANK2; DLG3; IL1R1; DLG1; DRD2; DLG4B; FLOT2; DLG2; GNAS
Function myosin V binding
Related Protein RAB25; RAB6A; RAB3C; RAB3D; RAB27A; RAB11A; RAB10; RAB6B; RAB11B; RAB8A
Function nucleotide binding
Related Protein Fert2; DOM3Z; RHOUA; DHX34; GLULA; ARL4CA; SPATA5; D19ERTD386E; CRCP; MAP2K4B
Function poly(A) RNA binding
Related Protein NPM3; RBM39; APEX1; RBMS2; PTBP2; DROSHA; NOL10; SNRPD2; MRPL15; LTA4H
Function protein binding
Related Protein ERO1L; RSPH3; MARK2; POLD2; PADI4; SIN3A; PPP2R5B; SPINLW1; SQSTM1; CD70
Function retinoid X receptor binding
Related Protein PPARG; NCOA1; RARB; NSD1; HMGA1-RS1; NR4A2; NRIP1; RARG; FUS; NR0B2
Function thyroid hormone receptor binding
Related Protein ZNHIT3; NSD1; HMGN3; NUP62; TAF7; OASL; TRIP6; GAS2L1; MED4; MED12
Function transcription coactivator activity
Related Protein NEUROD1; MYOCD; ACTL6B; MED17; JUNBA; UBE2L3; RXRA; RAN; JUP; JUPA
Function zinc ion binding
Related Protein CPZ; PDLIM3A; ZKSCAN5; MECR; USP3; ADAMTSL1; PJA2; RP9; MMP19; LNX2A

Interacting Protein

FUS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUS here. Most of them are supplied by our site. Hope this information will be useful for your research of FUS.
PLEC; EWSR1; TAF15; DROSHA; fus_ddit3

FUS Related Articles

Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
Shimamura, M; Kyotani, A; et al. Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway. EXPERIMENTAL CELL RESEARCH 326:36-45(2014).