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FUS

  • Official Full Name

    fused in sarcoma

  • Overview

    This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
  • Synonyms

    FUS; fused in sarcoma; TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2; RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FUS-13037H Recombinant Human FUS, GST-tagged E.coli GST 52-400a.a.
Human FUS-30143TH Recombinant Human FUS, His-tagged E.coli His
Human FUS-6118HCL Recombinant Human FUS 293 Cell Lysate HEK293 N/A
Human FUS-301394H Recombinant Human FUS protein, GST-tagged E.coli GST Gln52-Gly400
Human FUS-06H Active Recombinant Human FUS Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human FUS-947H Recombinant Human FUS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FUS-4555H Recombinant Human FUS Protein, GST-tagged Wheat Germ GST
Human FUS-10HFL Active Recombinant Full Length Human FUS Protein, C-Flag-tagged Mammalian cells Flag
Human FUS-461H Recombinant Human FUS Protein, His-tagged E.coli His Gly193~Cys444
Human FUS-947H-B Recombinant Human FUS Protein Pre-coupled Magnetic Beads HEK293
Human FUS-5669H Recombinant Human FUS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FUS-5159HF Recombinant Full Length Human FUS Protein, GST-tagged In Vitro Cell Free System GST 525 amino acids
Mouse FUS-6088M Recombinant Mouse FUS Protein Mammalian Cell His
Mouse Fus-462M Recombinant Mouse Fus Protein, His-tagged E.coli His Ser3~Arg267
Mouse Fus-3107M Recombinant Mouse Fus Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FUS-3391M-B Recombinant Mouse FUS Protein Pre-coupled Magnetic Beads HEK293
Mouse FUS-3391M Recombinant Mouse FUS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FUS-11307Z Recombinant Zebrafish FUS Mammalian Cell His
Chicken FUS-1121C Recombinant Chicken FUS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FUS Related Articles

FUS involved in several pathways and played different roles in them. We selected most pathways FUS participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerSSX1;PRCC;HIST1H3H;ARNT2;CDK14;MEIS1;HHEX;NTRK1;CD86

FUS has several biochemical functions, for example, DNA binding, RNA binding, estrogen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUS itself. We selected most functions FUS had, and list some proteins which have the same functions with FUS. You can find most of the proteins on our site.

Function Related Protein
DNA bindingRFX5;UBP1;H2AFVA;ZNF786;FOXF1;OVOL2;FLI1;STAT1B;PIAS1
RNA bindingHNRNPL2;PAPOLB;RNASEL;RPL14;SYNJ2;EIF4H;PATL1;ILF3;RBM14
estrogen receptor bindingTAF10;CTNNB1;CNOT1;DDX54;DDX5;DDX17;TRIP4;PADI2;HSD17B10
identical protein bindingPRPF3;UGP2;PYDC3;CEP72;NELL2;RB1;EPOR;COMMD1;GAPDH
ionotropic glutamate receptor bindingRAB4A;DRD2;DLG3;NETO1;ADRB2;CANX;SHANK1;DLG1;CACNG2
myosin V bindingRAB11B;RAB27A;RAB8A;RAB3B;RAB39B;RAB3D;RAB3C;RAB6B;RAB14
nucleotide bindingMRPL23;TAF15;RBM14B;ARL3L2;AKAP17A;RASL11A;CDK14;EXOSC10;PET112L
poly(A) RNA bindingHNRNPR;ZCCHC3;HNRNPA2B1;CSTF1;NAP1L4;ATXN2;ANXA2;MRPL21;PURG
protein bindingGPR85;CHD7;RPGRIP1;C11orf68;ANKRD49;LITAF;CPS1;MLLT1;PALM
retinoid X receptor bindingRARB;NRIP1;NCOA1;NCOR1;NR0B2;HMGA1-RS1;NSD1;NR4A2;PPARG
thyroid hormone receptor bindingMED30;GAS2L1;PRMT2;HMGN3;MED17;TAF7;MED13;MED1;TRIP6
transcription coactivator activityYAP1;TCF3;BRD7;SP100;MED1;NFE2L3;JUND;RAN;MTF1
zinc ion bindingRNF13;NEURL1AA;MYLIP;ZCCHC13;MID2;APOBEC2A;LTA4H;PDLIM7;BMP1A

FUS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUS here. Most of them are supplied by our site. Hope this information will be useful for your research of FUS.

PLEC; EWSR1; TAF15; DROSHA; fus_ddit3

Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
Shimamura, M; Kyotani, A; et al. Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway. EXPERIMENTAL CELL RESEARCH 326:36-45(2014).
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