FXYD7 Protein, FXYD domain containing ion transport regulator 7


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Official Full Name FXYD domain containing ion transport regulator 7
Background This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein.
Synonyms FXYD7; FXYD domain containing ion transport regulator 7; FXYD domain-containing ion transport regulator 7; FLJ25096
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FXYD7-13060H Recombinant Human FXYD7, GST-tagged E.coli GST
    Human FXYD7-6096HCL Recombinant Human FXYD7 293 Cell Lysate HEK293 N/A
    Mouse FXYD7-6109M Recombinant Mouse FXYD7 Protein Mammalian Cell His
    Rat FXYD7-2426R Recombinant Rat FXYD7 Protein Mammalian Cell His

    FXYD7 involved in several pathways and played different roles in them. We selected most pathways FXYD7 participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport FXYD7; TRPA1B; ANO10; MCOLN2; CLIC2; TRPC6A; MCOLN3; ATP11C; TRPC4APB; CLCN6
    Ion transport by P-type ATPases ATP11C; ATP1A1A.5; ATP8B1; ATP1A1A.4; FXYD6; ATP2B1B; CCC2; FXYD3; ATP13A5; ATP7B
    Transmembrane transport of small molecules ANO5; SLC28A2; TFR1B; SLC31A1; ADD3; GABRR2A; ABCA7; TRPM6; SLC38A4; ANO1

    FXYD7 has several biochemical functions, for example, ATPase binding, ion channel activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD7 itself. We selected most functions FXYD7 had, and list some proteins which have the same functions with FXYD7. You can find most of the proteins on our site.

    Function Related Protein
    ion channel activity KCNC3B; TRPC4A; SCN4AB; P2RX3A; ASIC4; CNGA5; FXYD2; CHRNA2A; HTR3B; KCNA6A
    protein binding RAD51L3; PPP6R2; SOCS5; OSTA; OLIG1; CYBRD1; Casp3; ST8SIA5; ATCAY; NACA
    sodium channel regulator activity SCN1BB; CAV3; YWHAH; SCN1B; FXYD3; PKP2; GPLD1; FXYD4; SGK2A; FGF12

    FXYD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD7.


    Li, BM; Hertz, L; et al. Cell-Specific mRNA Alterations in Na+, K+-ATPase alpha and beta Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug. NEUROCHEMICAL RESEARCH 38:834-841(2013).
    Moshitzky, S; Asher, C; et al. Intracellular Trafficking of FXYD1 (Phospholemman) and FXYD7 Proteins in Xenopus Oocytes and Mammalian Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 287:21130-21141(2012).

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