Fbl Protein, fibrillarin


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Official Full Name fibrillarin
Background This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Synonyms FBL; fibrillarin; rRNA 2-O-methyltransferase fibrillarin; FIB; FLRN; RNU3IP1; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1; CG9888 gene product from transcript CG9888-RA; 34 kD nucleolar scleroderma antigen; FBRL_HUMAN; FIB1; Nop1p; rRNA 2 O methyltransferase fibrillarin; CG9888-PA; Fib-PA; CG9888; Dmel\CG9888; Fibri; GCR-6; GCR6; pen59C5
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FBL-83H Recombinant Human Fibrillarin Protein, GST-tagged E.coli GST
    Human FBL-84H Recombinant Human Fibrillarin Protein, His-tagged E. coli His
    Mouse Fbl-1022M Recombinant Mouse Fbl Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human FBL-12762H Recombinant Human FBL, His-tagged E.coli His
    Human FBL-3869H Recombinant Human FBL Protein, GST-tagged Wheat Germ GST
    Human FBL-6319HCL Recombinant Human FBL 293 Cell Lysate HEK293 N/A
    Human FBL-791H Recombinant Human Fibrillarin, His-tagged E.coli His
    Human FBL-85H Recombinant Human FBL Protein, His-tagged E.coli His
    Human FBL-89H Recombinant Human FBL Protein, GST-tagged E.coli GST
    Mouse FBL-5698M Recombinant Mouse FBL Protein Mammalian Cell His
    Rat FBL-2281R Recombinant Rat FBL Protein Mammalian Cell His
    Rat Fbl-7817R Recombinant Rat Fbl protein, His & T7-tagged E.coli His/T7
    Zebrafish FBL-12246Z Recombinant Zebrafish FBL Mammalian Cell His

    Fbl involved in several pathways and played different roles in them. We selected most pathways Fbl participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fbl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome biogenesis in eukaryotes NXF2; cka2; EFTUD1; WDR43; RBM28; NAT10; EMG1; POP5; NHP2L1A; NXF3

    Fbl has several biochemical functions, for example, ATPase binding, RNA binding, TFIID-class transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fbl itself. We selected most functions Fbl had, and list some proteins which have the same functions with Fbl. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding NUFIP1; LCK; ATP6V1E1; DNAJB1; ZNHIT6; ATP6V0A1B; CAV1; ANK1; FXYD1; ATXN3
    RNA binding RBM23; TTC6; ATXN1L; PPP1R8; DDX59; SRP14; HNRPL; PPP5C; PCBP4; CPSF2
    TFIID-class transcription factor binding ERCC4; ERCC1; ZNHIT6; NOP58; FBL
    histone-glutamine methyltransferase activity FBL
    poly(A) RNA binding DDX39A; UNK; HSPA8; FKBP3; IMP3; C1orf131; LTA4H; SMC1A; SAP18; CHCHD1
    protein binding STAG3; PLD1; DHPS; CDK13; LRRC20; EMP1; PABPC1; NRXN1; CD74; APTX
    rRNA methyltransferase activity FBL; METTL23; DIMT1; RNMTL1B; TRMT10C; PRDM13; METTL8; RNMTL1A; FAM86; METTL21A

    Fbl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fbl here. Most of them are supplied by our site. Hope this information will be useful for your research of Fbl.

    SMN1; ARRB2; DDX5; LOC100911617; Prmt3; Prmt1; Prmt1; RTCA; RIOK3; CFLAR; CIAO1

    Hisamoto, N; Li, C; et al. The C-elegans HGF/Plasminogen-like Protein SVH-1 Has Protease-Dependent and -Independent Functions. CELL REPORTS 9:1628-1634(2014).

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