|Official Full Name||fibrillarin|
|Background||This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.|
|Synonyms||FBL; fibrillarin; rRNA 2-O-methyltransferase fibrillarin; FIB; FLRN; RNU3IP1; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1; CG9888 gene product from transcript CG9888-RA; 34 kD nucleolar scleroderma antigen; FBRL_HUMAN; FIB1; Nop1p; rRNA 2 O methyltransferase fibrillarin; CG9888-PA; Fib-PA; CG9888; Dmel\CG9888; Fibri; GCR-6; GCR6; pen59C5|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Fbl involved in several pathways and played different roles in them. We selected most pathways Fbl participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fbl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ribosome biogenesis in eukaryotes||NXF2; cka2; EFTUD1; WDR43; RBM28; NAT10; EMG1; POP5; NHP2L1A; NXF3|
Fbl has several biochemical functions, for example, ATPase binding, RNA binding, TFIID-class transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fbl itself. We selected most functions Fbl had, and list some proteins which have the same functions with Fbl. You can find most of the proteins on our site.
|ATPase binding||NUFIP1; LCK; ATP6V1E1; DNAJB1; ZNHIT6; ATP6V0A1B; CAV1; ANK1; FXYD1; ATXN3|
|RNA binding||RBM23; TTC6; ATXN1L; PPP1R8; DDX59; SRP14; HNRPL; PPP5C; PCBP4; CPSF2|
|TFIID-class transcription factor binding||ERCC4; ERCC1; ZNHIT6; NOP58; FBL|
|histone-glutamine methyltransferase activity||FBL|
|poly(A) RNA binding||DDX39A; UNK; HSPA8; FKBP3; IMP3; C1orf131; LTA4H; SMC1A; SAP18; CHCHD1|
|protein binding||STAG3; PLD1; DHPS; CDK13; LRRC20; EMP1; PABPC1; NRXN1; CD74; APTX|
|rRNA methyltransferase activity||FBL; METTL23; DIMT1; RNMTL1B; TRMT10C; PRDM13; METTL8; RNMTL1A; FAM86; METTL21A|
Fbl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fbl here. Most of them are supplied by our site. Hope this information will be useful for your research of Fbl.
SMN1; ARRB2; DDX5; LOC100911617; Prmt3; Prmt1; Prmt1; RTCA; RIOK3; CFLAR; CIAO1