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Folr1

  • Official Full Name

    folate receptor 1 (adult)

  • Overview

    The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
  • Synonyms

    FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus/Rhesus
  • Cynomolgus/Rhesus macaque
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi|His
  • C
  • 6His
  • Avi
  • His
  • Fc
  • GST
  • hFc
  • His (Fc)
  • His\Avi
  • His|Avi
  • N/A
  • Strep
  • Twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOLR1-178H Active Recombinant Human FOLR1 protein, Twin-Strep-tagged HEK293 Twin-Strep Arg25-Met233
Human FOLR1-3889H Recombinant Human FOLR1, His tagged Human Cell His
Human FOLR1-030H Active Recombinant Human FOLR1 protein, His-tagged HEK293 His Arg25-Met233
Human FOLR1-2103HCL Recombinant Human FOLR1 cell lysate Human Cell N/A
Human FOLR1-4419H Recombinant Human FOLR1 Protein, GST-tagged Wheat Germ GST
Human FOLR1-241H Recombinant Human FOLR1 Protein, His-tagged E.coli His Arg25~Ser234
Human FOLR1-039HG Active GMP Recombinant Human FOLR1 protein HEK293 DNA sequence encoding Human FOLR1(UniProtKB - P15328) was expressed with His tag at the C-terminal.
Human FOLR1-031H Active Recombinant Human FOLR1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human FOLR1-301148H Recombinant Human FOLR1 protein, GST-tagged E.coli GST Glu55-Ala93
Human FOLR1-679H Active Recombinant Human FOLR1 protein, His-tagged HEK293 His Arg25-Met233
Human FOLR1-5035HF Recombinant Full Length Human FOLR1 Protein, GST-tagged In Vitro Cell Free System GST 257 amino acids
Human FOLR1-203H Recombinant Human FOLR1 Protein, His\Avi-tagged Human Cell His\Avi
Human FOLR1-251H Recombinant Human FOLR1 Protein, His-tagged HEK293 His 257
Human FOLR1-4148H Recombinant Human FOLR1 Protein (Met1-Met233), C-His tagged Mammalian cells C-His Met1-Met233
Human FOLR1-31H Recombinant Human FOLR1 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Arg25-Ser234
Human FOLR1-678H Active Recombinant Human FOLR1 protein, hFc-tagged HEK293 hFc Arg25-Met233
Human FOLR1-1465H Active Recombinant Human FOLR1 protein, His-tagged, FITC-Labeled HEK293 His Arg25-Met233
Human FOLR1-1466H Active Recombinant Human FOLR1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Arg25-Met233
Human FOLR1-252H Recombinant Human FOLR1 Protein, Strep-tagged HEK293 Strep 257
Human FOLR1-2531H Recombinant Human FOLR1 Protein (Arg25-Ser234), C-His tagged Mammalian cells C-His Arg25-Ser234
Human FOLR1-4664H Active Recombinant Human FOLR1 Protein, His-tagged, PE-Labeled HEK293 His Arg 25 - Met 233
Human FOLR1-1467H Active Recombinant Human FOLR1 protein, Fc-tagged HEK293 Fc Arg25-Met233
Mouse Folr1-4045M Active Recombinant Mouse Folr1, His-tagged HEK293 His
Mouse Folr1-4044M Recombinant Mouse Folr1, His tagged Human Cell His
Mouse Folr1-0630M Recombinant Mouse Folr1 protein, His-tagged, Biotinylated HEK293 His Thr 25 - Ser 232
Mouse Folr1-7816M Recombinant Mouse Folr1 protein, Avi & His-tagged HEK293 Avi/His Thr 25 - Ser 232
Mouse FOLR1-2113MCL Recombinant Mouse FOLR1 cell lysate Human Cell N/A
Mouse FOLR1-317M Active Recombinant Mouse FOLR1 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Thr 25 - Ser 232
Mouse FOLR1-316M Recombinant Mouse FOLR1 protein, His-tagged HEK293 His 208
Mouse FOLR1-253M Recombinant Mouse FOLR1 Protein, His-tagged HEK293 His 255
Rat FOLR1-1146R Recombinant Rat FOLR1 Protein, Fc-tagged HEK293 Fc
Rat FOLR1-1147R Recombinant Rat FOLR1 Protein, His-tagged HEK293 His
Rat FOLR1-1146RAF555 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 445
Rat FOLR1-1146RAF647 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 445
Rat Folr1-242R Recombinant Rat Folr1 Protein, His-tagged E.coli His Arg26~Glu229
Rat FOLR1-1146RF Recombinant Rat FOLR1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 445
Rat FOLR1-1146RAF488 Recombinant Rat FOLR1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 445
Rat FOLR1-1146RP Recombinant Rat FOLR1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat FOLR1-1146RA Recombinant Rat FOLR1 protein, Fc-tagged, APC labeled HEK293 Fc
Dog FOLR1-1062CAF647 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 442
Dog FOLR1-1062CAF555 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 442
Dog FOLR1-1062CF Recombinant Canine FOLR1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 442
Dog FOLR1-1062CAF488 Recombinant Canine FOLR1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 442
Canine FOLR1-1062C Recombinant Canine FOLR1 Protein, Fc-tagged HEK293 Fc
Canine FOLR1-1063C Recombinant Canine FOLR1 Protein, His-tagged HEK293 His
Canine FOLR1-1062CP Recombinant Canine FOLR1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Canine FOLR1-1062CA Recombinant Canine FOLR1 protein, Fc-tagged, APC labeled HEK293 Fc
Cynomolgus/Rhesus FOLR1-953C Recombinant Cynomolgus/Rhesus FOLR1 protein, His-tagged HEK293 His Met1-Ser234
Cynomolgus/Rhesus macaque FOLR1-315C Active Recombinant Cynomolgus/Rhesus macaque FOLR1 protein, His-tagged HEK293 His Arg 25 - Met 233
Rhesus Macaque FOLR1-1736R Recombinant Rhesus monkey FOLR1 Protein, His-tagged Mammalian Cell His
Rhesus macaque FOLR1-250R Recombinant Rhesus macaque FOLR1 Protein, His-tagged HEK293 His 257
Rhesus Macaque FOLR1-1558R Recombinant Rhesus Macaque FOLR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FOLR1-1558R-B Recombinant Rhesus Macaque FOLR1 Protein Pre-coupled Magnetic Beads HEK293
Chicken FOLR1-6397C Recombinant Chicken FOLR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Folr1 Related Articles
  • Folr1 Related Research Area

Folr1 involved in several pathways and played different roles in them. We selected most pathways Folr1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Folr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisSMAD2;ARF6;DNM1A;GRK1;F2R;WASLA;CCR5;ARRB2;STAM

Folr1 has several biochemical functions, for example, drug binding, folic acid binding, folic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Folr1 itself. We selected most functions Folr1 had, and list some proteins which have the same functions with Folr1. You can find most of the proteins on our site.

Function Related Protein
drug bindingCHRNB2;SFRP1;GRIK1;PPARD;MT3;HTR2C;SIGMAR1;PDE4C;P2RX2
folic acid bindingFOLR3;SLC19A1;GNMT;MTHFS;TYMS;DHFR;DAAM2;FOLR2;SLC46A1
folic acid transporter activitySLC19A2;SLC19A1;SLC46A1;SLC25A32;DAAM2;FOLR2;FOLR1
methotrexate bindingFOLR1;DAAM2;DHFR;FOLR2
receptor activityCD5;PAQR9;TLR1;PAQR3B;ITGB1B.1;VMN1R43;CUBN;GABRA5;ATP6AP2

Folr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Folr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Folr1.

ganglioside_gm1; Cdk1; Cbx1; Cep76; Cep192; Trim69; Poc1b; Dync1h1; CUL3; NCAPH2; IRAK3; cona_canen

Wen, YF; Graybill, WS; et al. Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer. CLINICAL CANCER RESEARCH 21:448-459(2015).
Kabel, M; Madore, J; et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. BRITISH JOURNAL OF CANCER 111:2297-2307(2014).
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Customer Reviews (3)

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Reviews
02/25/2022

    The packaging is exquisite, with convenient sealing for long-term stability and activity preservation.

    08/07/2020

      The quality is highly reliable, consistently delivering consistent results with each use, which is crucial for my research.

      02/03/2019

        It is incredibly user-friendly, allowing both beginners and experienced laboratory personnel to easily operate it.

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