folr1
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  • Official Full Name
  • folate receptor 1 (adult)
  • Background
  • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
  • Synonyms
  • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;
Cat.#:FOLR1-031HTag:His|Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLR1 Protein, His-Avi-tagged, Biotinylated
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Cat.#:FOLR1-1062CATag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine FOLR1 protein, Fc-tagged, APC labeled
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Cat.#:FOLR1-1062CPTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine FOLR1 protein, Fc-tagged, R-PE labeled
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Cat.#:FOLR1-1146RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FOLR1 protein, Fc-tagged, APC labeled
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Cat.#:FOLR1-1146RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FOLR1 protein, Fc-tagged, R-PE labeled
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Cat.#:FOLR1-317MTag:His|Avi
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FOLR1 Protein, His & Avi-tagged, Biotinylated
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Cat.#:FOLR1-241HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOLR1 Protein, His-tagged
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Cat.#:FOLR1-4419HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FOLR1 Protein, GST-tagged
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Cat.#:Folr1-242RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Folr1 Protein, His-tagged
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Cat.#:FOLR1-315CTag:His
Source (Host):HEK293Species:Cynomolgus/Rhesus macaque
Product nameRecombinant Cynomolgus/Rhesus macaque FOLR1 protein, His-tagged
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Cat.#:FOLR1-316MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FOLR1 protein, His-tagged
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Cat.#:FOLR1-030HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FOLR1 Protein, His-tagged
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Cat.#:FOLR1-178HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLR1, Twin-Strep-tagged
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Cat.#:FOLR1-3889HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLR1, His tagged
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Cat.#:Folr1-0630MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folr1 protein, His-tagged, Biotinylated
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Cat.#:Folr1-4044MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folr1, His tagged
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Cat.#:Folr1-4045MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folr1, His-tagged
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Cat.#:Folr1-7816MTag:Avi|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folr1 protein, Avi & His-tagged
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Cat.#:FOLR1-1146RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FOLR1 Protein, Fc-tagged
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Cat.#:FOLR1-1147RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FOLR1 Protein, His-tagged
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Cat.#:FOLR1-1736RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FOLR1 Protein, His-tagged
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Cat.#:FOLR1-1062CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine FOLR1 Protein, Fc-tagged
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Cat.#:FOLR1-1063CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine FOLR1 Protein, His-tagged
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Cat.#:FOLR1-6397CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FOLR1
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Cat.#:FOLR1-2103HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLR1 cell lysate
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Cat.#:FOLR1-2113MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FOLR1 cell lysate
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Involved Pathway

Folr1 involved in several pathways and played different roles in them. We selected most pathways Folr1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Folr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
RAB11B; HSPA6; CHMP1B; RAB5C; ERBB3; WIPF2; ARF1L; PSD; CXCR4A; SNX1

Protein Function

Folr1 has several biochemical functions, for example, drug binding, folic acid binding, folic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Folr1 itself. We selected most functions Folr1 had, and list some proteins which have the same functions with Folr1. You can find most of the proteins on our site.
Function
Related Protein
Function drug binding
Related Protein CHRNA7; DAAM2; Alb; ADH1; DRD4; TYMS; CNR1; GABRA1; PDE4C; CHRM3
Function folic acid binding
Related Protein DHFR; MTHFS; DMGDH; GNMT; SLC19A1; SLC46A1; FTCD; FOLR2; FOLR1; FOLR3
Function folic acid transporter activity
Related Protein FOLR1; DAAM2; FOLR2; SLC46A1; SLC19A2; SLC25A32; SLC19A1
Function methotrexate binding
Related Protein DAAM2; FOLR2; FOLR1; DHFR
Function receptor activity
Related Protein CHRM3; CALCR; TNFRSF17; LRP2; Tnfrsf22; MED4; EXTL3; GRIA3B; GRIA2B; TNFRSF11B

Interacting Protein

Folr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Folr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Folr1.
ganglioside_gm1; Cdk1; Cbx1; Cep76; Cep192; Trim69; Poc1b; Dync1h1; CUL3; NCAPH2; IRAK3; cona_canen

Folr1 Related Articles

Wen, YF; Graybill, WS; et al. Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer. CLINICAL CANCER RESEARCH 21:448-459(2015).
Kabel, M; Madore, J; et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. BRITISH JOURNAL OF CANCER 111:2297-2307(2014).