Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

GABBR1

Official Full Name

gamma-aminobutyric acid (GABA) B receptor, 1
Overview

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA;exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic;(GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of;two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is;mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple;sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene;generates multiple transcript variants.
Synonyms

GABBR1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GABA B receptor; GPRC3A; hGB1a; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA) B receptor 1; Gb1; GABAB, subunit 1c; seven transmembrane helix receptor; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Flag
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GABBR1-28091TH	Recombinant Human GABBR1	Wheat Germ	N/A	100 amino acids	Inquiry
Human	GABBR1-8161H	Recombinant Human GABBR1 protein, His & T7-tagged	E.coli	His/T7	Val199~Gly570 (Accession# Q9UBS5)	Inquiry
Human	GABBR1-6073HCL	Recombinant Human GABBR1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GABBR1-4627H	Recombinant Human GABBR1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GABBR1-1116HFL	Recombinant Human GABBR1 protein, His&Flag-tagged	HEK293	His&Flag	1-961 aa	Inquiry
Human	GABBR1-5162HF	Recombinant Full Length Human GABBR1 Protein, GST-tagged	In Vitro Cell Free System	GST	844 amino acids	Inquiry
Mouse	GABBR1-6141M	Recombinant Mouse GABBR1 Protein	Mammalian Cell	His		Inquiry
Mouse	GABBR1-3424M-B	Recombinant Mouse GABBR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GABBR1-3424M	Recombinant Mouse GABBR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GABBR1-1789R	Recombinant Rhesus monkey GABBR1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GABBR1-1610R	Recombinant Rhesus Macaque GABBR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GABBR1-1610R-B	Recombinant Rhesus Macaque GABBR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GABBR1 Related Articles
GABBR1 Related Research Area

GABBR1 involved in several pathways and played different roles in them. We selected most pathways GABBR1 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cAMP signaling pathway	RELA;MLLT4;CREB3L2;NPY1R;PDE4C;PTCH1;CREB3L3;CALML3;PIK3R3
Neuroactive ligand-receptor interaction	PRP2;HTR1F;CCKAR;SSTR4;MLNR;GH2;GRIN1;GRIN2A;CHRM5B
GABAergic synapse	SRC;GABARAP;GABRB3;GNB1;GNB3;PLCL1;GNAO1;GNG3;GABRR1
Estrogen signaling pathway	HSPA1B;SP1;GRM1;ESR1;HSPA1A;KCNJ3;PIK3CD;RAF1;HSP90B1

GABBR1 has several biochemical functions, for example, G-protein coupled GABA receptor activity, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR1 itself. We selected most functions GABBR1 had, and list some proteins which have the same functions with GABBR1. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled GABA receptor activity	GABBR1;GPR156
contributes_to G-protein coupled GABA receptor activity	GABBR2;GABBR1
protein binding	DNM3;C9orf16;PSMD3;ZCCHC11;FASLG;CNTNAP1;MAP2K2;RPF1;KBTBD6

GABBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR1.

GABBR2; NSF; MAX; ABL1; FYN; NCK1; PIK3R1; CRK; GRB2; CHFR; ALB

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).

GABA Receptors

Osteoblast and Osteoclast Markers

Osteoclast Markers