Recombinant Human GABBR1 Protein, GST-tagged

• Cat.No.: GABBR1-4627H
• Product Overview: Human GABBR1 full-length ORF ( NP_068703.1, 1 a.a. - 844 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 121.5 kDa
• AA Sequence: MGPGAPFARVGWPLPLLVVMAAGVA PVWASHSPHLPRPHSRVPPHPSSER RAVYIGALFPMSGGWPGGQACQPAV EMALEDVNSRRDILPDYELKLIHHD SKCDPGQATKYLYELLYNDPIKIIL MPGCSSVSTLVAEAARMWNLIVLSY GSSSPALSNRQRFPTFFRTHPSATL HNPTRVKLFEKWGWKKIATIQQTTE VFTSTLDDLEERVKEAGIEITFRQS FFSDPAVPVKNLKRQDARIIVGLFY ETEARKVFCEVYKERLFGKKYVWFL IGWYADNWFKIYDPSINCTVDEMTE AVEGHITTEIVMLNPANTRSISNMT SQEFVEKLTKRLKRHPEETGGFQEA PLAYDAIWALALALNKTSGGGGRSG VRLEDFNYNNQTITDQIYRAMNSSS FEGVSGHVVFDASGSRMAWTLIEQL QGGSYKKIGYYDSTKDDLSWSKTDK WIGGSPPADQTLVIKTFRFLSQKLF ISVSVLSSLGIVLAVVCLSFNIYNS HVRYIQNSQPNLNNLTAVGCSLALA AVFPLGLDGYHIGRNQFPFVCQARL WLLGLGFSLGYGSMFTKIWWVHTVF TKKEEKKEWRKTLEPWKLYATVGLL VGMDVLTLAIWQIVDPLHRTIETFA KEEPKEDIDVSILPQLEHCSSRKMN TWLGIFYGYKGLLLLLGIFLAYETK SVSTEKINDHRAVGMAIYNVAVLCL ITAPVTMILSSQQDAAFAFASLAIV FSSYITLVVLFVPKMRRLITRGEWQ SEAQDTMKTGSSTNNNEEEKSRLLE KENRELEKIIAEKEERVSELRHQLQ SRQQLRSRRHPPTPPEPSGGLPRGP PEPPDRLSCDGSRVHLLYK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 [ Homo sapiens ]
• Official Symbol: GABBR1
• Synonyms: GABBR1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GABA B receptor; GPRC3A; hGB1a; GABA-BR1; GABAB, subunit 1c; seven transmembrane helix receptor; GB1; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613
• Gene ID: 2550
• mRNA Refseq: NM_001470
• Protein Refseq: NP_001461
• MIM: 603540
• UniProt ID: Q9UBS5