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Gas6

  • Official Full Name

    growth arrest-specific 6

  • Overview

    This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms

    GAS6; growth arrest-specific 6; AXSF; AXLLG; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAS6-613H Active Recombinant Human Growth Arrest-Specific 6, His-tagged Mammalian cells His
Human GAS6-623H Active Recombinant Human GAS6, His-tagged Mammalian cells His
Human GAS6-28979TH Recombinant Human GAS6 Wheat Germ N/A 100 amino acids
Human GAS6-477H Active Recombinant Human GAS6 protein, His-tagged HEK293 His Ala 49 - Ala 678
Human GAS6-622H Recombinant Human GAS6 (Ala31-Ala678), His-tagged E.coli His
Human GAS6-288TH Recombinant Human GAS6 full-length, GST-tagged Wheat Germ GST
Human GAS6-546H Recombinant Human GAS6 protein, His-tagged E.coli His Leu136~Phe311
Human GAS6-624H Recombinant Human GAS6, His-tagged E.coli His False
Human GAS6-6017HCL Recombinant Human GAS6 293 Cell Lysate HEK293 N/A
Human GAS6-3014H Recombinant Human GAS6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GAS6-383H Recombinant Human GAS6 protein, His-tagged HEK293 His Ala31-Ala678
Human GAS6-382H Recombinant Human GAS6(Ala31-Ala678) Protein, C-Fc-tagged HEK293 Fc
Human GAS6-1474H Active Recombinant Human GAS6 protein, His-tagged HEK293 His Asp279-Ala678
Human GAS6-3014H-B Recombinant Human GAS6 Protein Pre-coupled Magnetic Beads HEK293
Human GAS6-2540H Recombinant Human GAS6 Protein (Trp379-Ala678), N-His tagged E.coli N-His Trp379-Ala678
Mouse Gas6-8334M Active Recombinant Mouse Gas6 Mammalian cells N/A
Mouse Gas6-483M Active Recombinant Mouse Gas6, His-tagged Mammalian cells His
Mouse Gas6-1741M Recombinant Mouse Growth Arrest Specific 6, His-tagged Mammalian cells His
Mouse Gas6-195H Recombinant Mouse Gas6 Protein, His-tagged E.coli His Ala483~Gly646
Mouse GAS6-6218M Recombinant Mouse GAS6 Protein Mammalian Cell His
Mouse Gas6-196M Recombinant Mouse Gas6 Protein, His/GST-tagged E.coli His/GST Glu59~Asp221
Mouse Gas6-3478M-B Recombinant Mouse Gas6 Protein Pre-coupled Magnetic Beads HEK293
Mouse GAS6-898M Recombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged HEK293 His Met1-Pro674
Mouse Gas6-3478M Recombinant Mouse Gas6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gas6-197R Recombinant Rat Gas6 Protein, His-tagged E.coli His Glu100~Gln312
Rat Gas6-198R Recombinant Gas6 TRIM21 Protein, His-tagged E.coli His Leu356~Arg511
Rat Gas6-1563R Recombinant Rat Gas6 Protein, His&GST-tagged E.coli N-His&GST Glu100-Gln312
Zebrafish GAS6-10341Z Recombinant Zebrafish GAS6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gas6 Related Articles
  • Gas6 Related Research Area

Gas6 involved in several pathways and played different roles in them. We selected most pathways Gas6 participated on our site, such as Cell surface interactions at the vascular wall, Gamma carboxylation, hypusine formation and arylsulfatase activation, Gamma-carboxylation of protein precursors, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gas6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell surface interactions at the vascular wallPROCR;MERTK;BSG;CD84;DOK2;JAM2B;CD177;SLC3A2A;GLG1B
Gamma carboxylation, hypusine formation and arylsulfatase activationF9B;ARSJ;DOHH;ARSF;ARSE;ARSD;PROZ;DPH5;PROCA
Gamma-carboxylation of protein precursorsF9A;GAS6;PROCA;F9B;PROZ
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsFURINB;F9B;F9A;PROCA;GAS6;PROZ;FURINA
HemostasisRHOGA;HBBE2;AMICA1;GATA1;JAM2B;ATP2B1B;SLC3A2A;ABHD6B;S100A10
Metabolism of proteinsCBX8;SEC22A;MPDU1B;EID3;IGFBP1B;ARSK;ALG14;ST6GAL2B;TOMM6
Platelet activation, signaling and aggregationF13A1A.1;RHOGA;CLEC1B;ABHD12;MMRN1;C6orf25;MMRN2A;F13A1B;SCG3
Platelet degranulationF13A1B;SCG3;SPARC;IGF2B;HRG;SERPINF2B;SRGN;CD9B;GAS6

Gas6 has several biochemical functions, for example, binding, bridging, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Gas6 itself. We selected most functions Gas6 had, and list some proteins which have the same functions with Gas6. You can find most of the proteins on our site.

Function Related Protein
binding, bridgingPDCD6;TRADD;GAS6
calcium ion bindingPCDH2G9;DSG2.1;NCS1A;NOTCH1A;EFCAB6;PADI4;CIB4;PCDHB11;S100A6
cysteine-type endopeptidase inhibitor activity involved in apoptotic processNAIP1;ARRB1;RPS6KA3;IGF1RB;DPEP1;IGF1RA;C1QL4L;TNFSF14;XIAP
phosphatidylserine bindingJPH2;TRIM72;ANXA9;SYTL2;OSBPL10;MFGE8;THBS1;RASGRP1;OSBPL8
protein bindingIL2RG;SNCA;TRIP4;GPR3;STAC;MAL;CAMKK1;STAG3;KRT83
protein tyrosine kinase activator activityABI1B;ABI1;AFAP1L2;GHRL;ERBB3;ERCC6;Cd24a;NRG1;GAS6
receptor agonist activityWNT1;SFRP2;WNT3A;WNT5A;WNT8A;VEGFA;WNT4;WNT2;WNT10B
receptor bindingCYTL1;GRP;IL1RAPL1;TENC1;PDGFRB;CCL13;HIST2H3C2;PVR;TGFB2
receptor tyrosine kinase bindingFNTA;NRG1;ANGPT4;TOB1;HYAL2;DNAJA3;PITPNM3;Flt3l;NRG3
voltage-gated calcium channel activityCACNA2D4;ATP6V0CB;CACNA1D;CACNA1SB;CACNB2A;CACNG8;CACNB1;CACNG8A;CACNA1DA

Gas6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gas6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gas6.

AXL; ppdK; hemC

Choi, JY; Seo, JY; et al. Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation. SCIENCE SIGNALING 8:-(2015).
Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
  • Q&As
  • Reviews

Q&As (6)

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How are GAS6 protein expression levels associated with cardiovascular disease? 02/28/2022

Expression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.

How does GAS6 protein relate to other biomarkers? 12/13/2021

The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.

What is the role of GAS6 protein in tumor treatment? 01/24/2020

GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.

What is the role of GAS6 protein in the treatment of cardiovascular disease? 11/20/2019

Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore

How to use the expression level of GAS6 protein for tumor diagnosis and prognosis assessment? 11/02/2019

It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.

How is GAS6 protein expression related to tumors? 05/16/2019

Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.

Customer Reviews (3)

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Reviews
12/17/2022

    GAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.

    08/16/2022

      The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.

      07/06/2021

        Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.

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