gas6
Share
  • Official Full Name
  • growth arrest-specific 6
  • Background
  • This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms
  • GAS6; growth arrest-specific 6; AXSF; AXLLG; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand;
Cat.#:GAS6-383HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAS6 Protein, His-tagged
+Inquiry
Cat.#:GAS6-898MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged
+Inquiry
Cat.#:GAS6-288THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAS6 full-length, GST-tagged
+Inquiry
Cat.#:GAS6-613HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Growth Arrest-Specific 6, His-tagged
+Inquiry
Cat.#:GAS6-28979THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAS6
+Inquiry
Cat.#:GAS6-477HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GAS6
+Inquiry
Cat.#:GAS6-546HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6 protein, His-tagged
+Inquiry
Cat.#:GAS6-622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6 (Ala31-Ala678), His-tagged
+Inquiry
Cat.#:GAS6-623HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human GAS6, His-tagged
+Inquiry
Cat.#:GAS6-624HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6, His-tagged
+Inquiry
Cat.#:Gas6-1741MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Growth Arrest Specific 6, His-tagged
+Inquiry
Cat.#:Gas6-195HTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gas6 Protein, His-tagged
+Inquiry
Cat.#:Gas6-196MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gas6 Protein, His/GST-tagged
+Inquiry
Cat.#:Gas6-483MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Gas6, His-tagged
+Inquiry
Cat.#:GAS6-6218MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GAS6 Protein
+Inquiry
Cat.#:Gas6-8334MTag:
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Gas6
+Inquiry
Cat.#:Gas6-197RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gas6 Protein, His-tagged
+Inquiry
Cat.#:Gas6-198RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Gas6 TRIM21 Protein, His-tagged
+Inquiry
Cat.#:GAS6-10341ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GAS6
+Inquiry
Cat.#:GAS6-6017HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAS6 293 Cell Lysate
+Inquiry

Involved Pathway

Gas6 involved in several pathways and played different roles in them. We selected most pathways Gas6 participated on our site, such as Cell surface interactions at the vascular wall, Gamma carboxylation, hypusine formation and arylsulfatase activation, Gamma-carboxylation of protein precursors, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gas6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell surface interactions at the vascular wall
GRB14; BSG; AMICA1; SLC16A1; F11R.2; CEACAM6; GLG1B; CD177; MERTK; ESAMA
Gamma carboxylation, hypusine formation and arylsulfatase activation
SUMF2; EIF5A2; DPH5; PROZ; FURINB; DPH3; ARSH; DHPS; ARSJ; PROCA
Gamma-carboxylation of protein precursors
PROZ; PROCA; F9A; F9B; GAS6
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
PROZ; PROCA; F9A; FURINB; FURINA; GAS6; F9B
Hemostasis
HBG1; SLC8A2A; ATP2B3A; DOCK11; HBB-Y; SERPINA1L; SERPINB8; MERTK; KCNMB2; CFHL3
Metabolism of proteins
GAS6; ADAMTS15; SLC25A12; SENP5; IGFBP1A; CTSG; GRPEL2; HSCB; PPP6R3; EIF5A2
Platelet activation, signaling and aggregation
PDPN; HRG; SRGN; TRPC6A; SERPINF2B; RHOGA; CALU; F13A1B; ABHD6B; STXBP3
Platelet degranulation
CAP1; F13A1B; IGF2B; SPARC; SERPINF2B; MMRN1; MMRN2A; F13A1A.1; BRPF3; WDR1

Protein Function

Gas6 has several biochemical functions, for example, binding, bridging, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Gas6 itself. We selected most functions Gas6 had, and list some proteins which have the same functions with Gas6. You can find most of the proteins on our site.
Function
Related Protein
Function binding, bridging
Related Protein TRADD; GAS6; PDCD6
Function calcium ion binding
Related Protein SYT9; CELSR1; FAT3A; SLC25A13; EGF; SLIT1B; PLA2G1B; CDK5R1; PRRG1; NECAB1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein BIRC3; MT3; BIRC5; GAS6; XIAP; BIRC7; RPS6KA3; RPS6KA1; BIRC2; LEF1
Function phosphatidylserine binding
Related Protein FCHO2; AP1S2; MFGE8; OSBPL8; SCARB1; OSBPL5; MARK1; ANXA9; THBS1; ANXA13
Function protein binding
Related Protein HIST1H3A; CCT8; PGF; ARL6IP5; ARHGAP33; ROBO2; KRT17; VGLL4; ATPAF1; HIF1A
Function protein tyrosine kinase activator activity
Related Protein CD24; ABI1; AFAP1L2; ABI1B; ERCC6; Cd24a; GAS6; PAK2; NRG1; ERBB3
Function receptor agonist activity
Related Protein NODAL; WNT2; WNT7A; WNT8A; WNT3A; WNT1; GREM1; WNT3; CXCL13; GAS6
Function receptor binding
Related Protein NPPC; IZUMO1; CD72; CADM1B; RSPO2; NUDT19; HILPDA; PTK6; IDH1; FGF24
Function receptor tyrosine kinase binding
Related Protein FNTA; PLCG1; ZNF259; ELMO2; ANGPT1; TOB1; HYAL2; LRP4; SHC4; SHC3
Function voltage-gated calcium channel activity
Related Protein CACNG2A; GRM7; CACNG2; ATP6V0CB; CACNG7A; CACNB2B; CACNA1C; CACNA1BA; CATSPER3; CACNB4B

Interacting Protein

Gas6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gas6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gas6.
AXL; ppdK; hemC

Gas6 Related Articles

Choi, JY; Seo, JY; et al. Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation. SCIENCE SIGNALING 8:-(2015).
Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).