gas6
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  • Official Full Name
  • growth arrest-specific 6
  • Background
  • This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms
  • GAS6; growth arrest-specific 6; AXSF; AXLLG; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand;
Cat.#:GAS6-383HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAS6 Protein, His-tagged
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Cat.#:GAS6-898MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged
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Cat.#:GAS6-288THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAS6 full-length, GST-tagged
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Cat.#:GAS6-613HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Growth Arrest-Specific 6, His-tagged
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Cat.#:GAS6-28979THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAS6
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Cat.#:GAS6-477HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GAS6
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Cat.#:GAS6-546HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6 protein, His-tagged
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Cat.#:GAS6-622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6 (Ala31-Ala678), His-tagged
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Cat.#:GAS6-623HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human GAS6, His-tagged
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Cat.#:GAS6-624HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS6, His-tagged
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Cat.#:Gas6-1741MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Growth Arrest Specific 6, His-tagged
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Cat.#:Gas6-195HTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gas6 Protein, His-tagged
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Cat.#:Gas6-196MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gas6 Protein, His/GST-tagged
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Cat.#:Gas6-483MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Gas6, His-tagged
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Cat.#:GAS6-6218MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GAS6 Protein
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Cat.#:Gas6-8334MTag:
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Gas6
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Cat.#:Gas6-197RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gas6 Protein, His-tagged
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Cat.#:Gas6-198RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Gas6 TRIM21 Protein, His-tagged
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Cat.#:GAS6-10341ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GAS6
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Cat.#:GAS6-6017HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAS6 293 Cell Lysate
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Involved Pathway

Gas6 involved in several pathways and played different roles in them. We selected most pathways Gas6 participated on our site, such as Cell surface interactions at the vascular wall, Gamma carboxylation, hypusine formation and arylsulfatase activation, Gamma-carboxylation of protein precursors, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gas6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell surface interactions at the vascular wall
SLC7A11; SLC3A2B; BSG; ITGB1B.1; SLC16A8; TREM1; AMICA1; GRB7; PPIA; CEACAM1
Gamma carboxylation, hypusine formation and arylsulfatase activation
PROZ; DPH3; DNAJC24; WDR85; ARSD; ARSF; EIF5A2; DOHH; PROCA; EEF2
Gamma-carboxylation of protein precursors
PROZ; F9B; F9A; PROCA; GAS6
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
FURINA; PROCA; PROZ; F9B; F9A; GAS6; FURINB
Hemostasis
SLC16A1; HBE1; KIF2A; BA2; GATA2; F3A; KIF4A; IRF1B; TREM1; KIF11
Metabolism of proteins
HYOU1; O3far1; SPCS3; SLC38A8; TRAPPC1; LMCD1; DPH5; TRAPPC3; DPH2; VBP1
Platelet activation, signaling and aggregation
F13A1A.1; GNA13B; CLEC1B; FCER1GL; STXBP3; CD9B; SRGN; SPARC; SERPINF2B; CAP1
Platelet degranulation
CAP1; SCG3; GAS6; MMRN1; F13A1A.1; CALU; SERPINF2B; MMRN2A; WDR1; BRPF3

Protein Function

Gas6 has several biochemical functions, for example, binding, bridging, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Gas6 itself. We selected most functions Gas6 had, and list some proteins which have the same functions with Gas6. You can find most of the proteins on our site.
Function
Related Protein
Function binding, bridging
Related Protein PDCD6; GAS6; TRADD
Function calcium ion binding
Related Protein VSNL1A; ELTD1; PLCD1; MBL2; ASPH; MAN1B1; PCDHGA2; UBE4A; CD248; PCDH2AB5
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein TFAP2B; ARRB1; BIRC3; RPS6KA3; BIRC8; SERPINB9; IGF1RA; RPS6KA1; TNFSF14; DPEP1
Function phosphatidylserine binding
Related Protein OSBPL8; RPE65; THBS1; CPNE6; FCHO2; GAS6; OSBPL10; OSBPL5; SCIN; JPH2
Function protein binding
Related Protein WFS1; UBA1; CALML3; JAG1; CDC37; PTK6; FNIP1; GLUD1; PAGE5; UBE2D1
Function protein tyrosine kinase activator activity
Related Protein ABI1; ABI3A; ABI1B; GAS6; Cd24a; GHRL; ERCC6; AFAP1L2; ABI1A; ERBB3
Function receptor agonist activity
Related Protein CXCL13; WNT3A; WNT7A; GAS6; WNT4; VEGFA; WNT10B; WNT2; GREM1; WNT1
Function receptor binding
Related Protein UTS2; DAO1; APOL2; ABL2; P2RX4; FYNA; PANX1; C5; KNG1; CD2
Function receptor tyrosine kinase binding
Related Protein ANGPT2A; Flt3l; PLCG1; PTPN11; ZFP259; ANXA5; TP53; ELMO2; GNB2L1; TOB1
Function voltage-gated calcium channel activity
Related Protein CACNG6; TMC1; CALHM1; CACNG4; CACNG2; CACNA2D1; CACNA2D4; PKD2; CACNB2A; CACNA2D2

Interacting Protein

Gas6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gas6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gas6.
AXL; ppdK; hemC

Gas6 Related Articles

Choi, JY; Seo, JY; et al. Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation. SCIENCE SIGNALING 8:-(2015).
Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).