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Recombinant Human GAS6 protein, His-tagged

Cat.No. : GAS6-383H
Product Overview : Recombinant Human Growth Arrest-specific Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala31-Ala678 is expressed with a 6His tag at the C-terminus.
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Description : GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ala
Form : Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Molecular Mass : The recombinant human GAS6 consists of 641 amino acids and predicts a molecular mass of 71.2 kDa.
Protein length : Ala31-Ala678
Endotoxin : Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Store at < -20ºC, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μl. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
Gene Name : GAS6
Official Symbol : GAS6
Synonyms : AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; Gas6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6
Gene ID : 2621
mRNA Refseq : NM_000820.4
Protein Refseq : NP_000811.1
MIM : 600441
UniProt ID : Q14393

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How are GAS6 protein expression levels associated with cardiovascular disease? 02/28/2022

Expression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.

How does GAS6 protein relate to other biomarkers? 12/13/2021

The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.

What is the role of GAS6 protein in tumor treatment? 01/24/2020

GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.

What is the role of GAS6 protein in the treatment of cardiovascular disease? 11/20/2019

Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore

How to use the expression level of GAS6 protein for tumor diagnosis and prognosis assessment? 11/02/2019

It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.

How is GAS6 protein expression related to tumors? 05/16/2019

Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.

Customer Reviews (3)

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Reviews
12/17/2022

    GAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.

    08/16/2022

      The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.

      07/06/2021

        Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.

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