Recombinant Human GAS6 protein, His-tagged
Cat.No. : | GAS6-383H |
Product Overview : | Recombinant Human Growth Arrest-specific Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala31-Ala678 is expressed with a 6His tag at the C-terminus. |
- Specification
- Gene Information
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Description : | GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ala |
Form : | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4. |
Molecular Mass : | The recombinant human GAS6 consists of 641 amino acids and predicts a molecular mass of 71.2 kDa. |
Protein length : | Ala31-Ala678 |
Endotoxin : | Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Store at < -20ºC, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μl. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Shipping : | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | GAS6 |
Official Symbol : | GAS6 |
Synonyms : | AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; Gas6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6 |
Gene ID : | 2621 |
mRNA Refseq : | NM_000820.4 |
Protein Refseq : | NP_000811.1 |
MIM : | 600441 |
UniProt ID : | Q14393 |
Products Types
◆ Recombinant Protein | ||
GAS6-288TH | Recombinant Human GAS6 full-length, GST-tagged | +Inquiry |
GAS6-3014H | Recombinant Human GAS6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS6-898M | Recombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged | +Inquiry |
Gas6-3478M | Recombinant Mouse Gas6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS6-546H | Active Recombinant Human GAS6 Protein(Leu136~Phe311), His-tagged | +Inquiry |
◆ Lysates | ||
GAS6-6017HCL | Recombinant Human GAS6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionExpression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.
The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.
GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.
Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore
It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.
Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.
Customer Reviews (3)
Write a reviewGAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.
The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.
Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.
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