gfra1
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  • Official Full Name
  • GDNF family receptor alpha 1
  • Background
  • Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
  • Synonyms
  • GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1
Cat.#:GFRA1-2040HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA1 Protein, Fc/His-tagged
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Cat.#:GFRA1-4860HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GFRA1 Protein, GST-tagged
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Cat.#:GFRA1-712HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GFRA1 Protein, His-tagged
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Cat.#:GFRA1-1618HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human GDNF Family Receptor Alpha 1
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Cat.#:GFRA1-1854HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GFRA1 protein, His-tagged
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Cat.#:GFRA1-3161HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA1, His tagged
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Cat.#:GFRA1-3162HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA1 Protein, Fc-tagged
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Cat.#:GFRA1-8324HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human GFRA1
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Cat.#:GFRA1-832HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human GFRA1 Protein, Fc Chimera
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Cat.#:Gfra1-1855MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gfra1 protein, His & GST-tagged
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Cat.#:Gfra1-722MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gfra1, His tagged
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Cat.#:GFRA1-2514RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GFRA1 Protein
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Cat.#:GFRA1-293RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Gfra1, Fc tagged
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Cat.#:Gfra1-4085RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Gfra1, His tagged
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Cat.#:GFRA1-298CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine GFRA1, His tagged
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Cat.#:GFRA1-6659CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GFRA1
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Cat.#:GFRA1-2426HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA1 cell lysate
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Cat.#:GFRA1-2692MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse GFRA1 cell lysate
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Cat.#:GFRA1-961RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat GFRA1 cell lysate
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Cat.#:GFRA1-966CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine GFRA1 cell lysate
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Involved Pathway

GFRA1 involved in several pathways and played different roles in them. We selected most pathways GFRA1 participated on our site, such as Axon guidance, Developmental Biology, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
DPYSL2B; CSNK2B; PAK4; LOC608458; RASGRP4; SEMA3AA; EVL; SPTA1; NRP1A; PTPRA
Developmental Biology
KIF4A; GFRA4; DPYSL2B; CFL1; CRMP1; AP2A1; INSM1A; SPRED3; JAK1; PSPN
Diurnally regulated genes with circadian orthologs
CRY1; EIF4G2; CEBPB; MYF6; GFRA1; SF3A3; QKI; G0S2; ITM2B; STBD1
NCAM signaling for neurite out-growth
GDNF; NRTN; GFRA2; GFRA1; PSPN; COL9A1A; COL9A1B; GFRA4; ST8SIA2
NCAM1 interactions
GFRA1; PSPN; NRTN; COL9A1A; COL9A1B; GFRA2; GDNF; GFRA4
Signaling events regulated by Ret tyrosine kinase
GDNF; DOK6; DOK5; GFRA1; DOK4; PDLIM7

Protein Function

GFRA1 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA1 itself. We selected most functions GFRA1 had, and list some proteins which have the same functions with GFRA1. You can find most of the proteins on our site.
Function
Related Protein
Function glial cell-derived neurotrophic factor receptor activity
Related Protein GFRA2; GFRA1; GFRA4
Function receptor binding
Related Protein NRG4; C5; SLC27A2; PDGFRB; SRC; DECR2; HAO2; INHA; GBA; FIS1

Interacting Protein

GFRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA1.
SOCS3

GFRA1 Related Articles

Takashima, S; Kanatsu-Shinohara, M; et al. Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal. STEM CELL REPORTS 4:489-502(2015).
Hettige, NC; Zai, C; et al. Use of candidate gene markers to guide antipsychotic dosage adjustment. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 54:315-320(2014).

GFRA1 Related Gene Family

TGF