GLDC Protein, glycine dehydrogenase (decarboxylating)


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Official Full Name glycine dehydrogenase (decarboxylating)
Background Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Synonyms GLDC; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; GCSP; glycine cleavage system protein P; glycine deca
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GLDC-13294H Recombinant Human GLDC, His-tagged E.coli His
    Human GLDC-29067TH Recombinant Human GLDC Wheat Germ N/A
    Human GLDC-394H Recombinant Human GLDC Mammalian Cell His
    Human GLDC-492H Recombinant Human GLDC Protein, His-tagged E.coli His
    Human GLDC-4950H Recombinant Human GLDC Protein, GST-tagged Wheat Germ GST
    Mouse Gldc-494M Recombinant Mouse Gldc Protein, His-tagged E.coli His
    Mouse GLDC-6397M Recombinant Mouse GLDC Protein Mammalian Cell His
    Chicken GLDC-5895C Recombinant Chicken GLDC Mammalian Cell His
    Zebrafish GLDC-9957Z Recombinant Zebrafish GLDC Mammalian Cell His

    GLDC involved in several pathways and played different roles in them. We selected most pathways GLDC participated on our site, such as Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycine, serine and threonine metabolism TDH; SDS; GRHPRA; ALDH7A1; MAOB; AMT; GAMT; SRR; PGAM2; GATM
    Glyoxylate and dicarboxylate metabolism AFMID; GLUL; CAT; HAO2; GRHPR; GRHPRA; HYI; GLDC; DLDH; AGXTB
    Metabolic pathways CNDP1; EXT1A; INPP1; GALNT4; RRM2; AANAT; MTMR14; RDH10; NDUFAB1; HSD3B5
    Carbon metabolism PDHA1; ACAT2; MCEE; TPI1B; SHMT1; GPT; DLAT; PCCB; ALDOAB; PCCA

    GLDC has several biochemical functions, for example, electron carrier activity, glycine binding, glycine dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDC itself. We selected most functions GLDC had, and list some proteins which have the same functions with GLDC. You can find most of the proteins on our site.

    Function Related Protein
    electron carrier activity COX7A3; HSD17B6; QDPR; ACAD9; NOX4; GLRX5; AOX4; ACAD11; AOX1; GRX2
    glycine binding ALAS2; GNMT; GRIN2B; GSS; SRR; GLRA4A; SIX2A; GRIN1; GLDC; GRIN3B
    glycine dehydrogenase (decarboxylating) activity GLDC
    lyase activity CAR3; TYW1; CAR15; ENO2; CAR5A; CRY5; CBSB; GAD1B; ECHDC2; Car12

    GLDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDC here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDC.

    TNIP3; adhB; vacB; q9wmx2-pro_0000037550; ICT1; ULK2

    Martinez-Jacobo, L; Ortiz-Lopez, R; et al. Clinical and molecular delineation of duplication 9p24.3q21.11 in a patient with psychotic behavior. GENE 560:124-127(2015).
    Kim, HM; Jung, WH; et al. Site-specific metabolic phenotypes in metastatic breast cancer. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).

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