gldc
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  • Official Full Name
  • glycine dehydrogenase (decarboxylating)
  • Background
  • Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
  • Synonyms
  • GLDC; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; GCSP; glycine cleavage system protein P; glycine deca
Cat.#:GLDC-492HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLDC Protein, His-tagged
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Cat.#:GLDC-4950HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLDC Protein, GST-tagged
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Cat.#:Gldc-494MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gldc Protein, His-tagged
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Cat.#:GLDC-13294HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLDC, His-tagged
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Cat.#:GLDC-29067THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GLDC
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Cat.#:GLDC-394HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GLDC
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Cat.#:GLDC-6397MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GLDC Protein
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Cat.#:GLDC-5895CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLDC
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Cat.#:GLDC-9957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLDC
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Involved Pathway

GLDC involved in several pathways and played different roles in them. We selected most pathways GLDC participated on our site, such as Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycine, serine and threonine metabolism
SDS; BPGM; PHGDH; GRHPRA; PIPOX; AOC2; ALDH7A1; AGXTA; MAOA; GLDC
Glyoxylate and dicarboxylate metabolism
GLULA; CAT; CS; GRHPRA; SHMT2; GCSHA; DHDPSL; AMT; GLYCTK; AFMID
Metabolic pathways
NME6; GK; NMNAT3; AOC1; DAO1; CYP7A1; GMPS; SPR; CYP2C39; POLR2D
Carbon metabolism
OGDH; GAPDH; IDH3A; TPI1; HKDC1; MDH2; SDHDB; FH; GPT2L; PCCB

Protein Function

GLDC has several biochemical functions, for example, electron carrier activity, glycine binding, glycine dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDC itself. We selected most functions GLDC had, and list some proteins which have the same functions with GLDC. You can find most of the proteins on our site.
Function
Related Protein
Function electron carrier activity
Related Protein FDX1; ETFB; DERL3; GSR; GLRX3; ACOX2; AKR1C4; COX5A; ACADM; GRXCR1
Function glycine binding
Related Protein GRIN2B; GLDC; GSS; GLRA1; ALAS2; GLRA4B; GRIN3B; GNMT; GLRA2; GRIN3A
Function glycine dehydrogenase (decarboxylating) activity
Related Protein GLDC
Function lyase activity
Related Protein TSEN2; FH1; ALDOCA; CAR5A; TYW1B; POLL; PTGES2; CBSA; Car12; CAR3

Interacting Protein

GLDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDC here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDC.
TNIP3; adhB; vacB; q9wmx2-pro_0000037550; ICT1; ULK2

GLDC Related Articles

Martinez-Jacobo, L; Ortiz-Lopez, R; et al. Clinical and molecular delineation of duplication 9p24.3q21.11 in a patient with psychotic behavior. GENE 560:124-127(2015).
Kim, HM; Jung, WH; et al. Site-specific metabolic phenotypes in metastatic breast cancer. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).