GMEB1
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Official Full Name
glucocorticoid modulatory element binding protein 1
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Overview
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this genes role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011] -
Synonyms
GMEB1; glucocorticoid modulatory element binding protein 1; PIF96; P96PIF; glucocorticoid modulatory element-binding protein 1; GMEB-1; PIF p96; DNA-binding protein p96PIF; parvovirus initiation factor p96;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GMEB1 involved in several pathways and played different roles in them. We selected most pathways GMEB1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GMEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
GMEB1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GMEB1 itself. We selected most functions GMEB1 had, and list some proteins which have the same functions with GMEB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TCF3B;DPF2;ETV1;MIXL1;SMAD2;RFX6;NFE2L3;ZNF543;CEBPA |
| metal ion binding | PHF2;MECOM;PRKCD;ZBTB7C;AOX3;PARP12B;ZNF410;ITGB1BP3;ZNF839 |
| transcription coactivator activity | NR5A1;SERTAD2;TDRD3;MED26;MED13;HCFC1;NR1I3;PSMD9;JUN |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | YBX1;NPAS4;TFE3B;ETV6;TFAP4;ETV1;NDN;MEIS1;MEF2A |
GMEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GMEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GMEB1.
UBE2I; SMAD3; SMAD1; ATF7IP; SNIP1; TRIM63; SMURF2
- Q&As
- Reviews
Q&As (5)
Ask a questionGMEB1 binds to glucocorticoid receptors and modulates their activity, influencing the transcription of target genes involved in various biological processes.
GMEB1 has been shown to be involved in the regulation of cell proliferation and survival, and its dysregulation has been linked to cancer progression.
Research has suggested that GMEB1 mutations may be associated with certain immune disorders and inflammatory conditions, but further studies are needed to establish a clear link.
GMEB1 has been implicated in the regulation of immune-related gene expression, suggesting a potential role in modulating immune response and inflammation.
Studies have indicated that GMEB1 expression levels may correlate with patient response to glucocorticoid therapy in certain conditions, but more research is needed to validate its predictive value.
Customer Reviews (3)
Write a reviewThe GMEB1 protein is an exceptional choice that meets the highest standards of quality, making it perfectly suited for your experimental needs.
In addition to its exceptional quality, the GMEB1 protein is backed by excellent technical support offered by the manufacturer.
the GMEB1 protein is of the highest quality and perfectly suited for your experimental requirements.
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