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GRP

  • Official Full Name

    gastrin-releasing peptide

  • Overview

    Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. There are three different isoforms.
  • Synonyms

    GRP; gastrin-releasing peptide; BN; GRP-10; proGRP; preproGRP; gastrin-releasing peptide; bombesin; neuromedin C; pre-progastrin releasing peptide; OTTHUMP00000163646; OTTHUMP00000235893; OTTHUMP00000235894; OTTHUMP00000235895;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His|ABP
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRP-13547H Recombinant Human GRP, His-tagged E.coli His 1-148
Human GRP-891H Recombinant Human GRP protein, His & GST-tagged E.coli His/GST
Human GRP-78H Recombinant Human GRP Protein, His-tagged E.coli His Val24-Gln148
Human GRP-201H Recombinant Human GRP Protein, His-ABP-tagged E.coli His/ABP
Human GRP-5730HCL Recombinant Human GRP 293 Cell Lysate HEK293 N/A
Human GRP-5379H Recombinant Human GRP Protein, GST-tagged Wheat Germ GST
Human GRP-2626H Recombinant Human GRP Protein (Val24-Gln148), His tagged E.coli His Val24-Gln148
Human GRP-1199H Recombinant Human GRP Protein, His-tagged HEK293F N-His Ser54-Gln148
Human GRP-916H Recombinant Human GRP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GRP-1594H Recombinant Human GRP Protein, His&GST-tagged E.coli N-His&GST Gly31-Pro98
Human GRP-1254H Recombinant Human GRP protein, GST-tagged Yeast GST 54-121aa
Human GRP-5602HF Recombinant Full Length Human GRP Protein, GST-tagged In Vitro Cell Free System GST 148 amino acids
Human GRP-5437H Recombinant Human GRP Protein (Ser54-Asp121) E.coli Tag Free Ser54-Asp121
Mouse Grp-3313M Recombinant Mouse Grp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Grp-1595R Recombinant Rat Grp Protein, His-tagged E.coli N-His Ala24-Ser147
Zebrafish GRP-7487Z Recombinant Zebrafish GRP Mammalian Cell His
Chicken GRP-5236C Recombinant Chicken GRP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRP Related Articles

GRP involved in several pathways and played different roles in them. We selected most pathways GRP participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)GPR77;PNOC;GPR37B;UTS2;CCBP2;NMBA;KEL;GPR37L1;ADORA2B
G alpha (q) signalling eventsFFAR3;NPS;PROKR1A;UTS2D;EDNRB;TRIO;PMCH;DGKG;CHRM3
GPCR downstream signalingDCLRE1B;SST;ARHGEF25;GCGB;RGS6;ADRA2A;RGS4;ADORA1;RGS20
GPCR ligand bindingXK;CCL35.2;PPY;INSL3;RGR;LPAR2B;FPR-RS6;GPR65;PTHLH
Gastrin-CREB signalling pathway via PKC and MAPKGRP;RGS21;EDN2;LPAR1;NPFF;QRFP;ANXA1A;RGS19;TAE1
Incretin synthesis, secretion, and inactivationGRP;SLC38A8;GPR120;O3far1;DPP4;GPR119;SPCS3;CDX2;PCSK1
Metabolism of proteinsANKRD28;SPON1B;IGFALS;PAPPA2;ARSH;CXXC1;GAS6;CPB2;F9A
Peptide hormone metabolismSLC38A8;SPCS3;ACE;CPA3;INHBAA;CGB5;SLC30A5;GPR120;GZMH

GRP has several biochemical functions, for example, neuropeptide hormone activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRP itself. We selected most functions GRP had, and list some proteins which have the same functions with GRP. You can find most of the proteins on our site.

Function Related Protein
neuropeptide hormone activityNPFF;PENK;ADCYAP1;AVP;TRH;PPY;NPPA;QRFP;CRH
receptor bindingBMP2;FGF18B;FGF11;NRG1;RND1;AMN;NRG4;IAPP;FIS1

GRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRP here. Most of them are supplied by our site. Hope this information will be useful for your research of GRP.

Andersen, B; Nielsen, KF; et al. Characterization of Alternaria strains from Argentinean blueberry, tomato, walnut and wheat. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY 196:1-10(2015).
Er, E; Celikkan, H; et al. A new generation electrochemical sensor based on Graphene nanosheets/Gold nanoparticles/Nafion nanocomposite for determination of Silodosin. ELECTROCHIMICA ACTA 157:252-257(2015).
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