grp
Share
  • Official Full Name
  • gastrin-releasing peptide
  • Background
  • Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. There are three different isoforms.
  • Synonyms
  • GRP; gastrin-releasing peptide; BN; GRP-10; proGRP; preproGRP; gastrin-releasing peptide; bombesin; neuromedin C; pre-progastrin releasing peptide; OTTHUMP00000163646; OTTHUMP00000235893; OTTHUMP00000235894; OTTHUMP00000235895
Cat.#:GRP-78HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRP Protein, His-tagged
+Inquiry
Cat.#:GRP-5379HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRP Protein, GST-tagged
+Inquiry
Cat.#:GRP-13547HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRP, His-tagged
+Inquiry
Cat.#:GRP-201HTag:His|ABP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRP Protein, His-ABP-tagged
+Inquiry
Cat.#:GRP-891HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRP protein, His & GST-tagged
+Inquiry
Cat.#:GRP-5236CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRP
+Inquiry
Cat.#:GRP-7487ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GRP
+Inquiry
Cat.#:GRP-5730HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GRP 293 Cell Lysate
+Inquiry

Involved Pathway

GRP involved in several pathways and played different roles in them. We selected most pathways GRP participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
GPR68; RHOL; CCL35.2; TAAR1; DRD4; SSTR5; PROK2; EDN1; EDNRB; GPR55
G alpha (q) signalling events
LPAR5A; KALRN; TRH; ABHD6B; QRFP; LPAR2B; TRPC7; NMU; KISS1; LPAR2A
GPCR downstream signaling
DRD2; HCAR1-2; ADRB3; PTH; PDE10A; OPN1SW; RGS21; NMBA; RGR; GPR17
GPCR ligand binding
GPR55A; CHRM4; INSL5; CXCR6; SST1.1; TAC1; CCR8; GPR65; CRH; EDNRA
Gastrin-CREB signalling pathway via PKC and MAPK
LTB4R; EDN3; ARHGEF25; ANXA1A; LPAR2A; LPAR2B; GPRC6A; FPR-RS3; RGS19; NMBA
Incretin synthesis, secretion, and inactivation
PCSK1; SPCS3; DPP4; CDX2; SLC38A8; GPR120; GPR119; O3far1; GRP
Metabolism of proteins
TBCE; TMED10; GALNTL5; CCT7; KLHDC3; PHC3; EIF4H; NSFB; BET1; TIMM23
Peptide hormone metabolism
SPCS3; SLC30A6; SLC30A8; CPB1; BCHE; GPR120; SLC38A8; SLC30A5; EXOC8; CPB2

Protein Function

GRP has several biochemical functions, for example, neuropeptide hormone activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRP itself. We selected most functions GRP had, and list some proteins which have the same functions with GRP. You can find most of the proteins on our site.
Function
Related Protein
Function neuropeptide hormone activity
Related Protein QRFP; NPY; PPY; TRH; CRH; ADCYAP1; NTS; CORT; PENK; NPFFL
Function receptor binding
Related Protein UCN2; ANKRD13C; WNT2BB; NXPH1; HFE; CHRNA10; GNB2L1; HAO2; TNFSF13B; FGF18A

GRP Related Articles

Andersen, B; Nielsen, KF; et al. Characterization of Alternaria strains from Argentinean blueberry, tomato, walnut and wheat. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY 196:1-10(2015).
Er, E; Celikkan, H; et al. A new generation electrochemical sensor based on Graphene nanosheets/Gold nanoparticles/Nafion nanocomposite for determination of Silodosin. ELECTROCHIMICA ACTA 157:252-257(2015).