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HAND1

  • Official Full Name

    heart and neural crest derivatives expressed 1

  • Overview

    The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
  • Synonyms

    HAND1; heart and neural crest derivatives expressed 1; Hxt; eHand; Thing1; bHLHa27; heart- and neural crest derivatives-expressed protein 1; class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • T7
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAND1-7171H Recombinant Human Heart And Neural Crest Derivatives Expressed 1, His-tagged E.coli His 1-215aa
Human HAND1-13662H Recombinant Human HAND1, GST-tagged E.coli GST 1-215a.a.
Human HAND1-4566H Recombinant Human HAND1 Protein, GST-tagged Wheat Germ GST
Human HAND1-5639HCL Recombinant Human HAND1 293 Cell Lysate HEK293 N/A
Human HAND1-3349HF Recombinant Full Length Human HAND1 Protein, GST-tagged In Vitro Cell Free System GST 215 amino acids
Human HAND1-7172H Recombinant Human HAND1 protein, His-T7-tagged E.coli His/T7 Met1~Gln215
Mouse Hand1-7851M Recombinant Mouse Hand1 protein, His & T7-tagged E.coli His/T7 Met1~Gln216 (Accession # Q64279)
Rat HAND1-2786R Recombinant Rat HAND1 Protein Mammalian Cell His
Rat HAND1-2440R Recombinant Rat HAND1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HAND1-2440R-B Recombinant Rat HAND1 Protein Pre-coupled Magnetic Beads HEK293
Chicken HAND1-6524C Recombinant Chicken HAND1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAND1 Related Articles
  • HAND1 Related Research Area

HAND1 involved in several pathways and played different roles in them. We selected most pathways HAND1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsWNT1;ID3;WNT9B;ONECUT1;LIF;IGF1R;ZIC3;OTX1;AKT1

HAND1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, bHLH transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAND1 itself. We selected most functions HAND1 had, and list some proteins which have the same functions with HAND1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingRFX1;SIX5;LEF1;NKX6-1;SMAD6;JUND;MAFB;NFATC3;BATF3
bHLH transcription factor bindingTCF21;FOXH1;RUNX2;LMO2;USF1;EP300;MAP3K10;TCF3;SMAD3
enzyme bindingYWHAE;ESR1;EIF4E;HOXA9;APOA5;TAL1;MAP2K7;RAD9A;CYP2C19
identical protein bindingSTK10;UHRF1;PON2;CLDN14;SIRT1;CPT1A;C1QTNF6;ATG16L1;RAD51
protein bindingTRIM10;EEF1B2;NDUFA4;ADCY6;BOLL;ITGA3;SOST;SDC2;SPATA7
protein heterodimerization activityMID2;KCNN1;EXT1;ODZ4;HIST3H3;CENPA;NEUROD2;KCNH1;SNX5
protein homodimerization activityCARD9;PGCP;ODC1;UBE4A;NLGN4X;BCL2;GSS;FZD9;IDE
transcription coactivator activityESRRB;MED31;LPIN3;MED16;CTBP2;RAP2C;KAT5;NR1I2;CITED2
transcription corepressor activityCTBP2A;ANKRD1;ASXL1;ZNF593;SMARCA4;SETD8;SOD3;E2F6;HAND1
transcription factor bindingTWIST1;PIM1;NKX2-1;E2F2;HES2;EPN1;ARNT;REST;BCL2
contributes_to transcription regulatory region DNA bindingNFYA;NFYB;TCF12;NFYC;TCF3;HDAC4;NR1H3;ATF4;RXRA
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingBTG2;AEBP2;ZFPM1;BATF3;SREBF2;NFIL3-4;NFATC2;TGIF1;FOXO1

HAND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAND1.

Org, T; Duan, D; et al. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO JOURNAL 34:759-777(2015).
Li, D; Ji, L; et al. Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect. PLOS ONE 9:-(2014).
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