hand1
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  • Official Full Name
  • heart and neural crest derivatives expressed 1
  • Background
  • The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HAND1; heart and neural crest derivatives expressed 1; Hxt; eHand; Thing1; bHLHa27; heart- and neural crest derivatives-expressed protein 1; class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;
Cat.#:HAND1-4566HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HAND1 Protein, GST-tagged
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Cat.#:HAND1-13662HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HAND1, GST-tagged
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Cat.#:HAND1-7171HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Heart And Neural Crest Derivatives Expressed 1, His-tagged
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Cat.#:Hand1-7851MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hand1 protein, His & T7-tagged
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Cat.#:HAND1-2786RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HAND1 Protein
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Cat.#:HAND1-6524CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HAND1
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Cat.#:HAND1-5639HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HAND1 293 Cell Lysate
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Involved Pathway

HAND1 involved in several pathways and played different roles in them. We selected most pathways HAND1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
HAND1; LEFTY2; ACVR1B; ACVR2B; BMPR1A; IL6ST; BMP2; JARID2; ESRRB; WNT6

Protein Function

HAND1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, bHLH transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAND1 itself. We selected most functions HAND1 had, and list some proteins which have the same functions with HAND1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SREBF2; MYPOP; MED8; NR4A3; TGIF1; MEOX2; HINFP; RBPJA; SIX1; FLI1
Function bHLH transcription factor binding
Related Protein SP1; IKZF4; TCF21; SIRT1; MAP3K10; TWIST1; SMAD3; ASCL1; TCF3A; SOX9
Function enzyme binding
Related Protein ADORA2A; RXRA; CABYR; ABCD1; BLZF1; SRC; RFC5; THRB; TSPYL1; UGT1A9
Function identical protein binding
Related Protein CD247; SUN2; CLDN2; FXR2; TPCN1; CEP72; COIL; VIM; PAICS; SRPX2
Function protein binding
Related Protein CYGB; JUN; FAM53C; THG1L; RAD54L; WASH1; TSG101; SPTA1; PRKAR1A; FAM122A
Function protein heterodimerization activity
Related Protein CAV1; CAPN2; IL12B; PVRL1; SMC3; RAF1; DMRT3; F11R.1; HER11; USF1
Function protein homodimerization activity
Related Protein CPNE1; UGT1A6; PLD6; CCBL1; HAND1; CAMK2D; INHBB; TESCA; CR2; DAXX
Function transcription coactivator activity
Related Protein RB1; MYCBP; EDF1; NFYC; MED21; NPAT; MED12; RAN; NR1H4; HIF3A
Function transcription corepressor activity
Related Protein SRSF2; NEUROD2; MXD1; SIRT1; TGIF1; ZHX1; DR1; CSDA; FOXP3; E4F1
Function transcription factor binding
Related Protein TP53; TRIB1; VDRA; APBB2; H2-AB1; INSIG2; THRA; EPN1; PARP1; ARRB1
Function contributes_to transcription regulatory region DNA binding
Related Protein HAND1; NFYC; NFYA; TAF1; TCF3; NR1H3; RXRA; NFYB; HDAC4; ATF4
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein AEBP2; ZBTB20; BACH1; HELT; CUX2; NR2C1; DACH1; POU4F2; OVOL1; KCNIP3

HAND1 Related Articles

Org, T; Duan, D; et al. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO JOURNAL 34:759-777(2015).
Li, D; Ji, L; et al. Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect. PLOS ONE 9:-(2014).