HCCS
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Official Full Name
holocytochrome c synthase -
Overview
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
HCCS;holocytochrome c synthase;holocytochrome c synthase (cytochrome c heme lyase);cytochrome c-type heme lyase;CCHL;cytochrome c heme lyase;OTTHUMP00000022904;OTTHUMP00000022905;DKFZp779I1858;EC 4.4.1.17;Holocytochrome c type synthase;MCOPS7;OTTHUMP00000022903;OTTMUSP00000021173;OTTMUSP00000021174;RGD1563855;RP23-37L2.1;cytochrome c heme-lyase;holocytochrome c-type synthase
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
HCCS involved in several pathways and played different roles in them. We selected most pathways HCCS participated on our site, such as Porphyrin and chlorophyll metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | UGT1A3,COX10,UGT1A9,HMOX2,CPOX,UGT1A1,ALAS1,UGT2B7,UGT1A6,GUSB |
Protein Function
HCCS has several biochemical functions, for example, holocytochrome-c synthase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCCS itself. We selected most functions HCCS had, and list some proteins which have the same functions with HCCS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | FBXO40.1,ATF7,RNF216,BMPR1BA,PON3,CYP2D10,ZSCAN1,PPTC7A,ZBTB10,TRIM35-27 |
| holocytochrome-c synthase activity | HCCSA.1,HCCSB |
Interacting Protein
HCCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCCS here. Most of them are supplied by our site. Hope this information will be useful for your research of HCCS.
MROH1;CRTC3;TIMMDC1;MRPL17
Resources
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References
- Harada, K; Baba, Y; et al. LINE-1 Methylation Level and Patient Prognosis in a Database of 208 Hepatocellular Carcinomas. ANNALS OF SURGICAL ONCOLOGY 22:1280-1287(2015).
- Ei, S; Hibi, T; et al. Cryoablation Provides Superior Local Control of Primary Hepatocellular Carcinomas of > 2 cm Compared with Radiofrequency Ablation and Microwave Coagulation Therapy: An Underestimated Tool in the Toolbox. ANNALS OF SURGICAL ONCOLOGY 22:1294-1300(2015).
