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HEXB

  • Official Full Name

    hexosaminidase B (beta polypeptide)

  • Overview

    Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes.Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases.Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).
  • Synonyms

    HEXB; hexosaminidase B (beta polypeptide); beta-hexosaminidase subunit beta; Beta hexosaminidase beta chain; Beta N acetylhexosaminidase; Beta-hexosaminidase subunit beta chain A; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto oncogene 7 protein; Cervical cancer proto-oncogene 7 protein; ENC 1AS; HCC 7; HCC-7; HCC7; HEX B; HEXB_HUMAN; Hexosaminidase B; Hexosaminidase subunit B; HexosaminidaseB; N acetyl beta glucosaminidase; N-acetyl-beta-glucosaminidase subunit beta; ENC-1AS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HEXB-644H Recombinant Human HEXB protein, His-tagged E.coli His Lys315~Tyr456 (Accession # P07686)
Human HEXB-4711H Recombinant Human HEXB Protein, GST-tagged Wheat Germ GST
Human HEXB-27728TH Recombinant Human HEXB Wheat Germ N/A 556 amino acids
Human HEXB-302H Active Recombinant Human HEXB protein, His-tagged HEK293 His Ala43-Met556
Human HEXB-645H Recombinant Human HEXB protein, His-tagged E.coli His Thr122~Ser311 (Accession # P07686)
Human HEXB-756HCL Recombinant Human HEXB cell lysate Human Cell N/A
Human HEXB-1150H Recombinant Human HEXB protein, His&Myc-tagged E.coli His&Myc 122-556aa
Human HEXB-1063H-B Recombinant Human HEXB Protein Pre-coupled Magnetic Beads HEK293
Human HEXB-2446H Recombinant Human HEXB Protein (Lys315-Tyr456), His tagged E.coli His Lys315-Tyr456
Human HEXB-1090H Recombinant Human HEXB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HEXB-228HF Recombinant Full Length Human HEXB Protein In Vitro Cell Free System 556 amino acids
Human HEXB-3524HF Recombinant Full Length Human HEXB Protein, GST-tagged In Vitro Cell Free System GST 556 amino acids
Human HEXB-0753H Recombinant Human HEXB Protein Mammalian cells Tag Free
Human HEXB-1983HFL Recombinant Full Length Human HEXB Protein, C-Flag-tagged Mammalian cells Flag
Human HEXB-1063H Recombinant Human HEXB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hexb-647M Recombinant Mouse Hexb protein, His-tagged E.coli His Lys294~Tyr435 (Accession # P20060)
Mouse Hexb-1014M Recombinant Mouse Hexb Protein, His-tagged HEK293 His
Mouse Hexb-646M Recombinant Mouse Hexb protein, His-tagged E.coli His Pro101~Ile217 (Accession # P20060)
Mouse HEXB-7594M Recombinant Mouse HEXB Protein Mammalian Cell His
Mouse Hexb-1117M Recombinant Mouse Hexb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HEXB-4139M-B Recombinant Mouse HEXB Protein Pre-coupled Magnetic Beads HEK293
Mouse HEXB-4139M Recombinant Mouse HEXB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HEXB-2834R Recombinant Rat HEXB Protein Mammalian Cell His
Rat Hexb-648R Recombinant Rat Hexb protein, His & T7-tagged E.coli His/T7 Pro100~Ile216
Rat HEXB-2489R-B Recombinant Rat HEXB Protein Pre-coupled Magnetic Beads HEK293
Rat HEXB-2489R Recombinant Rat HEXB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HEXB-2070R Recombinant Rhesus monkey HEXB Protein, His-tagged Mammalian Cell His
Rhesus Macaque HEXB-1891R-B Recombinant Rhesus Macaque HEXB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HEXB-1891R Recombinant Rhesus Macaque HEXB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HEXB Related Articles

HEXB involved in several pathways and played different roles in them. We selected most pathways HEXB participated on our site, such as Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEXB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Other glycan degradationNEU3.3;MAN2B2;NEU4;FUCA1.2;ENG-1;HEXB;FUCA2;NEU3;AGA
Amino sugar and nucleotide sugar metabolismHK3;GKUP;UGDH;PGM2;nanA;GPIB;GPR19;UAP1L1;CMAS
Glycosaminoglycan degradationHPSE2;GNS;GLB1;HYAL3;HGSNAT;SPAM1;HPSE;HYAL6;NAGLU
Glycosphingolipid biosynthesis - globo seriesST3GAL1;NAGA;B3GALNT1;GBGT1L4;FUT9;B3GALT5;HEXB;GBGT1;HEXA
Glycosphingolipid biosynthesis - ganglio seriesB4GALNT1;HEXB;B3GALT4;ST6GALNAC5;HEXA;ST3GAL1;ST6GALNAC6;ST6GALNAC3;ST8SIA1
Metabolic pathwaysPOLR2F;CYP2A4;COX6C;NME7;MINPP1A;MVDA;NDUFA10;POLR3D;GBE1
LysosomeCTSBB;GALC;TCIRG1;CLN3;NAGLU;ATP6V0B;CD63;GUSB;ATP6V0D1

HEXB has several biochemical functions, for example, acetylglucosaminyltransferase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEXB itself. We selected most functions HEXB had, and list some proteins which have the same functions with HEXB. You can find most of the proteins on our site.

Function Related Protein
acetylglucosaminyltransferase activityUGGT1;MGAT1;XYLT1;B3GNT8;MGAT1B;GTDC2;EXT1;GALNTL4;MGAT1A
beta-N-acetylhexosaminidase activityHEXB;HEXDC;HEXA;Chil3
protein heterodimerization activityHOMER1;SYT5;GCA;SDCBP;MID1;DMRTA2;VAPB;TIRAP;UNC13A
protein homodimerization activityKCNN2;GSTZ1;ASCL1;TPR;RQCD1;BCL2A1A;GSTM1;HAND1;ANG

HEXB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEXB here. Most of them are supplied by our site. Hope this information will be useful for your research of HEXB.

CSNK2B; SOD1; Tuba3a; Bach1; Nup214; Tgs1; SMC6; TSNAX; Kif19

Villamizar-Schiller, IT; Pabon, LA; et al. Neurological and cardiac responses after treatment with miglustat and a ketogenic diet in a patient with Sandhoff disease. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:180-183(2015).
Walia, JS; Altaleb, N; et al. Long-Term Correction of Sandhoff Disease Following Intravenous Delivery of rAAV9 to Mouse Neonates. MOLECULAR THERAPY 23:414-422(2015).
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