hip1
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  • Official Full Name
  • huntingtin interacting protein 1
  • Background
  • The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ; HIP-I; huntingtin-interacting protein I; MGC126506
Cat.#:HIP1-4755HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HIP1 Protein, GST-tagged
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Cat.#:HIP1-13782HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HIP1, GST-tagged
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Cat.#:HIP1-1738HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HIP1 protein, His & T7-tagged
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Cat.#:HIP1-26095THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HIP1
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Cat.#:HIP1-28314THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HIP1
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Cat.#:Hip1-5638MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Huntingtin Interacting Protein 1, His-tagged
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Cat.#:HIP1-7634MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HIP1 Protein
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Cat.#:HIP1-7597ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HIP1
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Cat.#:HIP1-788HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HIP1 cell lysate
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Involved Pathway

HIP1 involved in several pathways and played different roles in them. We selected most pathways HIP1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Huntingtons disease
COX7B2; TAF4B; NDUFB9; ATP5D; COX8C; BAX; COX6B2; TBP; UQCRC1; EP300

Protein Function

HIP1 has several biochemical functions, for example, actin binding, clathrin binding, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIP1 itself. We selected most functions HIP1 had, and list some proteins which have the same functions with HIP1. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein HIP1; FLII; AFAP1; CLMN; PDLIM5; MYH13; FHL3; SYN1; WASF1; DAAM1B
Function clathrin binding
Related Protein SYT12; PICALMB; SYT13; DNER; SYT9B; AFTPHA; SYT1A; TOM1; SYT15; DOC2B
Function phosphatidylinositol binding
Related Protein NISCH; SNX27B; SNX13; PXK; SNX9; SNX19A; HIP1; HIP1RB; NOXO1; SH3YL1
Function protein binding
Related Protein DYNLT1; NTN4; RIPPLY1; CD5; SLA2; GDAP2; SPRED1; FKBP3; MKI67IP; PRSS21
Function structural constituent of cytoskeleton
Related Protein ACTL7B; TPM1; KRT2; ACTA1; DMD; ACTG1; LOR; TUBA3E; KRT20; ARPC5

Interacting Protein

HIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIP1.
HTT; CLTCL1; CLTC; REL; DAZAP2; AP2A1

HIP1 Related Articles

Yan, R; Chen, MX; et al. Glycoprotein lb alpha clustering induces macrophage-mediated platelet clearance in the liver. THROMBOSIS AND HAEMOSTASIS 113:107-117(2015).
Masuda, T; Sakuma, C; et al. Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head. CONGENITAL ANOMALIES 53:141-148(2013).