Recombinant Human HIP1 cell lysate

• Cat.No.: HIP1-788HCL

Specification

• Species: Human
• Tag: Non
• Description: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: HIP1 huntingtin interacting protein 1 [ Homo sapiens ]
• Official Symbol: HIP1
• Synonyms: HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ; HIP-I; huntingtin-interacting protein I; MGC126506
• Gene ID: 3092
• mRNA Refseq: NM_001243198
• Protein Refseq: NP_001230127
• MIM: 601767
• UniProt ID: O00291
• Chromosome Location: 7q11.23
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem
• Function: actin binding; clathrin binding; phosphatidylinositol binding; protein binding; structural constituent of cytoskeleton