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HSD17B10

  • Official Full Name

    hydroxysteroid (17-beta) dehydrogenase 10

  • Overview

    Mutations in several genes associated with early onset Alzheimer’s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer’s disease.
  • Synonyms

    HSD17B10; hydroxysteroid (17-beta) dehydrogenase 10; HADH2, hydroxyacyl Coenzyme A dehydrogenase, type II, hydroxyacyl Coenzyme A dehydrogenase, type II , mental retardation, X linked, syndromic 10 , MRXS10; 3-hydroxyacyl-CoA dehydrogenase type-2; 17b HSD10; AB binding alcohol dehydrogenase; ABAD; CAMR; ERAB; MHBD; MRPP2; SDR5C1; short chain dehydrogenase/reductase family 5C; member 1; type 10 17b HSD; type 10 17beta hydroxysteroid dehydrogenase; AB-binding alcohol dehydrogenase; mitochondrial ribonuclease P protein 2; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; short chain type dehydrogenase/reductase XH98G2; amyloid-beta peptide binding alcohol dehydrogenase; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain dehydrogenase/reductase family 5C, member 1; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; HCD2; HADH2; MRX17; MRX31; SCHAD; MRXS10; 17b-HSD10; DUPXp11.22;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD17B10-7002H Recombinant Human HSD17B10, GST-tagged Sf9 Insect Cell GST Full length
Human HSD17B10-28686TH Recombinant Human HSD17B10 N/A
Human HSD17B10-1707H Recombinant Human Hydroxysteroid Dehydrogenase 10, His-tagged Human His
Human HSD17B10-28684TH Recombinant Human HSD17B10, His-tagged E.coli His
Human HSD17B10-5064H Recombinant Human HSD17B10 Protein, GST-tagged Wheat Germ GST
Human HSD17B10-5376HCL Recombinant Human HSD17B10 293 Cell Lysate HEK293 N/A
Human HSD17B10-4780H Recombinant Human HSD17B10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSD17B10-4781H Recombinant Human HSD17B10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HSD17B10-2656H Recombinant Human HSD17B10 Protein (Met1-Pro261), C-His tagged Mammalian cells C-His Met1-Pro261
Human HSD17B10-1101H Recombinant Human HSD17B10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSD17B10-4769H Recombinant Human HSD17B10 protein, His-SUMO-tagged E.coli His-SUMO 2-261aa
Human HSD17B10-1101H-B Recombinant Human HSD17B10 Protein Pre-coupled Magnetic Beads HEK293
Human HSD17B10-3805HF Recombinant Full Length Human HSD17B10 Protein, GST-tagged In Vitro Cell Free System GST 261 amino acids
Human HSD17B10-341HFL Recombinant Full Length Human HSD17B10 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Hsd17b10-1408M Recombinant Mouse Hsd17b10 protein, His & T7-tagged E.coli His/T7 Ala4~Ala202 (Accession # O08756)
Mouse Hsd17b10-1093M Recombinant Mouse Hsd17b10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HSD17B10-2273R Recombinant Rat HSD17B10 Protein (2-261 aa), His-tagged Yeast His 2-261 aa
Cynomolgus Monkey HSD17B10-597C Recombinant Cynomolgus HSD17B10 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HSD17B10-343C Recombinant Cynomolgus Monkey HSD17B10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HSD17B10-343C-B Recombinant Cynomolgus Monkey HSD17B10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSD17B10-2153R Recombinant Rhesus monkey HSD17B10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSD17B10-1974R-B Recombinant Rhesus Macaque HSD17B10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSD17B10-1974R Recombinant Rhesus Macaque HSD17B10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HSD17B10-1604Z Recombinant Zebrafish HSD17B10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HSD17B10 involved in several pathways and played different roles in them. We selected most pathways HSD17B10 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Valine, leucine and isoleucine degradationIL4I1;AOX2P;HSD17B10;AUH;BCAT1;ALDH3A2A;ACADM;ALDH9A1A.1;HIBCH
Metabolic pathwaysITPK1A;CEPT1;POLR1B;MIBP;GANAB;NDUFV2;NDUFA2;AGK;UGT2A1
Alzheimers diseasePPP3R2;NAE1;NDUFA4L2;NDUFV2;CALM3;ATP5H;CALM2;NDUFB9;APBB1

HSD17B10 has several biochemical functions, for example, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity, 3-hydroxyacyl-CoA dehydrogenase activity, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B10 itself. We selected most functions HSD17B10 had, and list some proteins which have the same functions with HSD17B10. You can find most of the proteins on our site.

Function Related Protein
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
3-hydroxyacyl-CoA dehydrogenase activityH2-KE6;HADHB;HADHA;HSD17B10;HADHAB;HSD17B4;HADHAA;HSD17B8;EHHADH
NAD bindingSORD;LDHA;AHCY;HIBADHB;HIBADH;MDH1;AOX3;TESCA;GRHPRB
acetoacetyl-CoA reductase activity
beta-amyloid bindingTM2D1;TSSK1B;APOE;IDE;APBB1;ARMCX5-GPRASP2;LDLRAP1;Apba1;CHRNA7
cholate 7-alpha-dehydrogenase activity
estradiol 17-beta-dehydrogenase activityRDH8A;RDH8;HSD17B7;HSD17B2;H2-KE6;AKR1B15;HSD17B1;HSD17B10;HSD17B12B
estrogen receptor bindingPPARG;ISL1;TRIP4;PHB2;TAF10;ARRB1;HSD17B10;NRIP1;DDX5
identical protein bindingBRAP;BIN1;VAMP2;TNN;SDCBP;EGFR;C1QL2;LUC7L;ALCAMA
poly(A) RNA bindingZNF385A;MKI67IP;MTIF2;CCDC137;KRT18;MRTO4;C2orf15;SNTB2;RPL11
protein bindingMAPK11;CDC45;GJD3;LPAR2;PPP2R5B;TBC1D9B;CBLL1;AGPAT4;REEP5
steroid bindingUGT1A1;CYP21A2;ESRRB;FAM84B;ESRRGA;PAQR8;ESR2A;ESRRA;PDIA2
testosterone dehydrogenase [NAD(P)] activity

HSD17B10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B10.

APP; TRMT10C; mt-trna_tyr_rna; KIAA0391; HTRA2; UBE2D1; CHD3; q7cie3_yerpe; FAF1; Srp72; NOP56; GABARAP

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