Recombinant Rat HSD17B10 Protein (2-261 aa), His-tagged

• Cat.No.: HSD17B10-2273R
• Product Overview: Recombinant Rat HSD17B10 Protein (2-261 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Full Length of Mature Protein.

Specification

• Description: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids.
• Source: Yeast
• Species: Rat
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 29.1 kDa
• Protein length: 2-261 aa
• AA Sequence: AAAVRSVKGLVAVITGGASGLGLST AKRLVGQGATAVLLDVPNSEGETEA KKLGGNCIFAPANVTSEKEVQAALT LAKEKFGRIDVAVNCAGIAVAIKTY HEKKNQVHTLEDFQRVINVNLIGTF NVIRLVAGVMGQNEPDQGGQRGVII NTASVAAFEGQVGQAAYSASKGGIV GMTLPIARDLAPIGIRVVTIAPGLF ATPLLTTLPDKVRNFLASQVPFPSR LGDPAEYAHLVQMVIENPFLNGEVI RLDGAIRMQP
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [ Rattus norvegicus ]
• Official Symbol: HSD17B10
• Synonyms: HSD17B10; type II HADH; 17-beta-HSD 10; Hadh2
• Gene ID: 63864
• mRNA Refseq: NM_031682
• Protein Refseq: NP_113870
• UniProt ID: O70351