Recombinant Human HSD17B10 Protein, Myc/DDK-tagged

• Cat.No.: HSD17B10-4781H
• Product Overview: Recombinant protein of human hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), nuclear gene encoding mitochondrial protein, transcript variant 1 with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Description: This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
• Source: HEK293T
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 25.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 [ Homo sapiens (human) ]
• Official Symbol: HSD17B10
• Synonyms: HSD17B10; hydroxysteroid 17-beta dehydrogenase 10; ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; HSD10MD; 17b-HSD10; DUPXp11.22; 3-hydroxyacyl-CoA dehydrogenase type-2; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; AB-binding alcohol dehydrogenase; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; mitochondrial RNase P subunit 2; mitochondrial ribonuclease P protein 2; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain type dehydrogenase/reductase XH98G2; EC 1.1.1.159; EC 1.1.1.178; EC 1.1.1.239; EC 1.1.1.35; EC 1.1.1.53; EC 1.1.1.62
• Gene ID: 3028
• mRNA Refseq: NM_004493
• Protein Refseq: NP_004484
• MIM: 300256
• UniProt ID: Q99714