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HSD17B2

  • Official Full Name

    hydroxysteroid (17-beta) dehydrogenase 2

  • Overview

    Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.
  • Synonyms

    HSD17B2; hydroxysteroid (17-beta) dehydrogenase 2; estradiol 17-beta-dehydrogenase 2; HSD17; SDR9C2; short chain dehydrogenase/reductase family 9C; member 2; 17 beta HSD 2; 20 alpha HSD; 20 alpha hydroxysteroid dehydrogenase; E2DH; Microsomal 17 beta hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase; 20-alpha-HSD; 17-beta-HSD 2; OTTHUMP00000174979; testosterone 17-beta-dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 2; microsomal 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 9C, member 2; EDH17B2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD17B2-206H Recombinant Human HSD17B2, GST-tagged Wheat Germ GST
Human HSD17B2-5375HCL Recombinant Human HSD17B2 293 Cell Lysate HEK293 N/A
Human HSD17B2-1104H Recombinant Human HSD17B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSD17B2-2258H Recombinant Human HSD17B2 Protein, His-tagged E.coli N-His Glu104-Thr387
Human HSD17B2-1104H-B Recombinant Human HSD17B2 Protein Pre-coupled Magnetic Beads HEK293
Human HSD17B2-99HFL Recombinant Full Length Human HSD17B2 Protein, C-Flag-tagged Mammalian cells Flag
Human HSD17B2-6951HF Recombinant Full Length Human HSD17B2 Protein, GST-tagged In Vitro Cell Free System GST 387 amino acids
Human HSD17B2-1364H Recombinant Human HSD17B2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse HSD17B2-7877M Recombinant Mouse HSD17B2 Protein Mammalian Cell His
Mouse Hsd17b2-1637M Recombinant Mouse Hsd17b2 Protein, His&GST-tagged E.coli N-His&GST Gln158-His381
Mouse Hsd17b2-1178M Recombinant Mouse Hsd17b2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HSD17B2-4334M-B Recombinant Mouse HSD17B2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSD17B2-4334M Recombinant Mouse HSD17B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD17B2-2926R Recombinant Rat HSD17B2 Protein Mammalian Cell His
Rat HSD17B2-2581R Recombinant Rat HSD17B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD17B2-2581R-B Recombinant Rat HSD17B2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey HSD17B2-600C Recombinant Cynomolgus HSD17B2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HSD17B2-346C-B Recombinant Cynomolgus Monkey HSD17B2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey HSD17B2-346C Recombinant Cynomolgus Monkey HSD17B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL23332HF Recombinant Full Length Human 17-Beta-Hydroxysteroid Dehydrogenase Type 2(Hsd17B2) Protein, His-Tagged E.coli expression system His Full Length (1-387)
Mus musculus (Mouse) RFL31495MF Recombinant Full Length Mouse Estradiol 17-Beta-Dehydrogenase 2(Hsd17B2) Protein, His-Tagged E.coli expression system His Full Length (1-381)
Zebrafish HSD17B2-3728Z Recombinant Zebrafish HSD17B2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSD17B2 Related Articles

HSD17B2 involved in several pathways and played different roles in them. We selected most pathways HSD17B2 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisHSD3B1;CYP2C50;CYP2C45;UGT1A4;HSD3B6;CYP3A65;CYP21A1;STS;HSD17B12
Metabolic pathwaysFUT8A;CEPT1;DNMT3AB;GALNT9;DHODH;HK1;TRIT1;ATP5J;UGP2B
Ovarian steroidogenesisSTAR;PRKACA;IGF1;HSD3B6;HSD3B4;GDF9;PTGS2;BMP6;CYP2J6

HSD17B2 has several biochemical functions, for example, 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, estradiol 17-beta-dehydrogenase activity, testosterone dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B2 itself. We selected most functions HSD17B2 had, and list some proteins which have the same functions with HSD17B2. You can find most of the proteins on our site.

Function Related Protein
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activityHSD17B2;AKR1C6
estradiol 17-beta-dehydrogenase activityAKR1C6;HSD17B6;RDH8;HSD17B8;RDH8B;H2-KE6;RDH8A;HSD17B1;HSD17B14
testosterone dehydrogenase (NAD+) activityHSD17B6;DHRS9;AKR1C3;HSD17B1;HSD17B8;HSD17B2;H2-KE6

HSD17B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B2.

Cheng, YH; Imir, A; et al. SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. BIOLOGY OF REPRODUCTION 75:605-614(2006).
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