hsd17b3
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  • Official Full Name
  • hydroxysteroid (17-beta) dehydrogenase 3
  • Background
  • This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone.It preferentially uses NADP as cofactor.Deficiency can result in male pseudohermaphroditism with gynecomastia.
  • Synonyms
  • HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; testosterone 17-beta-dehydrogenase 3; SDR12C2; short chain dehydrogenase/reductase family 12C; member 2; 17 @beta HSD III; 17 beta HSD 3; 17-@beta hydroxysteroid dehydrogenase III; 17-beta-hydroxysteroid dehydrogenase type 3; EC 1.1.1.64; EDH17B3; Estradiol 17 beta dehydrogenase; Estradiol 17 beta dehydrogenase 3; Hydroxysteroid (17 beta) dehydrogenase 3; OTTHUMP00000021718; Testicular 17 @beta hydroxysteroid dehydrogenaseIII; Testicular 17 beta hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase 3; 17-beta-HSD3; 17-beta-HSD 3; testicular 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 12C, member 2
Cat.#:HSD17B3-5070HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSD17B3 Protein, GST-tagged
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Cat.#:HSD17B3-13959HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B3, GST-tagged
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Cat.#:HSD17B3-1407HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B3 protein, His-tagged
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Cat.#:HSD17B3-7878MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HSD17B3 Protein
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Cat.#:HSD17B3-2927RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSD17B3 Protein
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Cat.#:HSD17B3-2155RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HSD17B3 Protein, His-tagged
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Cat.#:HSD17B3-10685ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HSD17B3
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Cat.#:HSD17B3-5374HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HSD17B3 293 Cell Lysate
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Involved Pathway

HSD17B3 involved in several pathways and played different roles in them. We selected most pathways HSD17B3 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Steroid hormone biosynthesis
UGT1A2; CYP2B19; UGT1A6; SRD5A2; HSD17B12; HSD17B12B; COMTA; AKR1C2; UGT1A7; SRD5A1
Metabolic pathways
LDHA; PLCD1B; PIPOX; HPSE2; PSAT1; PRPS1A; POLR2A; LTA4H; CERS2; B4GALNT1

Protein Function

HSD17B3 has several biochemical functions, for example, testosterone 17-beta-dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B3 itself. We selected most functions HSD17B3 had, and list some proteins which have the same functions with HSD17B3. You can find most of the proteins on our site.
Function
Related Protein
Function testosterone 17-beta-dehydrogenase (NADP+) activity
Related Protein HSD17B3; HSD17B14; AKR1C3; AKR1C6

Interacting Protein

HSD17B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B3.
BUB1; ERBB2; CDH1; BRAF; MCC; CTNNA1; MLH1; SMAD2; DLC1; MLH3

HSD17B3 Related Articles

Guo, JJ; Li, XW; et al. The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. TOXICOLOGY 306:9-15(2013).