Recombinant Full Length Human HSD17B3 Protein, C-Flag-tagged

• Cat.No.: HSD17B3-1439HFL
• Product Overview: Recombinant Full Length Human HSD17B3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 34.3 kDa
• AA Sequence: MGDVLEQFFILTGLLVCLACLAKCV RFSRCVLLNYWKVLPKSFLRSMGQW AVITGAGDGIGKAYSFELAK RGLNVVLISRTLEKLEAIATEIERT TGRSVKIIQADFTKDDIYEHIKEKL AGLEIGILVNNVGMLPNLLP SHFLNAPDEIQSLIHCNITSVVKMT QLILKHMESRQKGLILNISSGIALF PWPLYSMYSASKAFVCAFSK ALQEEYKAKEVIIQVLTPYAVSTAM TKYLNTNVITKTADEFVKESLNYVT IGGETCGCLAHEILAGFLSL
  IPAWAFYSGAFQRLLLTHYVAYLKL NTKVRTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Metabolic pathways

Gene Information

• Gene Name: HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 [ Homo sapiens (human) ]
• Official Symbol: HSD17B3
• Synonyms: EDH17B3; SDR12C2
• Gene ID: 3293
• mRNA Refseq: NM_000197.2
• Protein Refseq: NP_000188.1
• MIM: 605573
• UniProt ID: P37058