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HTR4

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 4

  • Overview

    This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
  • Synonyms

    HTR4; 5-hydroxytryptamine (serotonin) receptor 4; 5-hydroxytryptamine receptor 4; 5 HT4; 5 HT 4; 5 HT4R; 5 hydroxytryptamine 4 receptor; 5 hydroxytryptamine receptor 4; 5 hydroxytryptamine serotonin receptor 4; 5 hydroxytryptamine4 receptor; 5H4; 5HT 4; 5HT4; 5HT4R; Cardiac 5 HT4 receptor; HTR 4; Serotonin 5 HT4 receptor; Serotonin receptor 4; OTTHUMP00000160384; OTTHUMP00000224250; OTTHUMP00000224252; OTTHUMP00000224254; OTTHUMP00000224281; OTTHUMP00000224282; OTTHUMP00000224307; OTTHUMP00000235919; cardiac 5-HT4 receptor; 5-HT4; 5-HT4R;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cavia porcellus (Guinea pig)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR4-829HCL Recombinant Human HTR4 cell lysate N/A
Human HTR4-3817H Recombinant Human HTR4 protein, His-tagged E.coli His 301-388 aa
Human HTR4-5237H Recombinant Human HTR4 Protein, GST-tagged Wheat Germ GST
Human HTR4-5238H Recombinant Human HTR4 Protein Wheat Germ N/A
Human HTR4-5694HF Recombinant Full Length Human HTR4 Protein In Vitro Cell Free System 139 amino acids
Human HTR4-5696HF Recombinant Full Length Human HTR4 Protein, GST-tagged In Vitro Cell Free System GST 388 amino acids
Mouse HTR4-7937M Recombinant Mouse HTR4 Protein Mammalian Cell His
Mouse HTR4-4378M Recombinant Mouse HTR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HTR4-4378M-B Recombinant Mouse HTR4 Protein Pre-coupled Magnetic Beads HEK293
Rat HTR4-2967R Recombinant Rat HTR4 Protein Mammalian Cell His
Rat HTR4-2622R-B Recombinant Rat HTR4 Protein Pre-coupled Magnetic Beads HEK293
Rat HTR4-2622R Recombinant Rat HTR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cavia porcellus (Guinea pig) RFL13015CF Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 4(Htr4) Protein, His-Tagged E.coli expression system His Full Length (1-388)
Homo sapiens (Human) RFL27880HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 4(Htr4) Protein, His-Tagged E.coli expression system His Full Length (1-388)
Mus musculus (Mouse) RFL8363MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 4(Htr4) Protein, His-Tagged E.coli expression system His Full Length (1-388)
Rattus norvegicus (Rat) RFL11110RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 4(Htr4) Protein, His-Tagged E.coli expression system His Full Length (1-406)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTR4 Related Research Area

HTR4 involved in several pathways and played different roles in them. We selected most pathways HTR4 participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPHKB;RYR2;PRKCB;PLCD3;PRKCG;SLC25A4;CHRM5B;ORAI2;PTGER1
cAMP signaling pathwayROCK1;SOX9;HTR1F;AMH;PDE3A;RYR2;PLCE1;ATP1B1;HHIP
Neuroactive ligand-receptor interactionTAAR10D;CHRNA4;HTR2B;NMUR1;TBXA2R;PTH1R;GABRR3A;GRM2;CHRNA7
Serotonergic synapseHTR1A;MAPK1;SLC18A1;CYP2J6;GABRB3;MAOA;PRKCA;PRKCG;HTR2B

HTR4 has several biochemical functions, for example, serotonin receptor activity, NOT trace-amine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR4 itself. We selected most functions HTR4 had, and list some proteins which have the same functions with HTR4. You can find most of the proteins on our site.

Function Related Protein
serotonin receptor activityHTR2B;HTR3B;HTR1B;HTR2CL1;HTR6;HTR1F;HTR1AA;HTR1D;HTR4
NOT trace-amine receptor activity

HTR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR4.

serotonin; gr 113808; ADRB2

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