htr4
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  • Official Full Name
  • 5-hydroxytryptamine (serotonin) receptor 4
  • Background
  • This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
  • Synonyms
  • HTR4; 5-hydroxytryptamine (serotonin) receptor 4; 5-hydroxytryptamine receptor 4; 5 HT4; 5 HT 4; 5 HT4R; 5 hydroxytryptamine 4 receptor; 5 hydroxytryptamine receptor 4; 5 hydroxytryptamine serotonin receptor 4; 5 hydroxytryptamine4 receptor; 5H4; 5HT 4; 5HT4; 5HT4R; Cardiac 5 HT4 receptor; HTR 4; Serotonin 5 HT4 receptor; Serotonin receptor 4; OTTHUMP00000160384; OTTHUMP00000224250; OTTHUMP00000224252; OTTHUMP00000224254; OTTHUMP00000224281; OTTHUMP00000224282; OTTHUMP00000224307; OTTHUMP00000235919; cardiac 5-HT4 receptor; 5-HT4; 5-HT4R
Cat.#:HTR4-5237HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HTR4 Protein, GST-tagged
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Cat.#:HTR4-5238HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HTR4 Protein
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Cat.#:HTR4-7937MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HTR4 Protein
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Cat.#:HTR4-2967RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HTR4 Protein
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Cat.#:HTR4-829HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HTR4 cell lysate
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Involved Pathway

HTR4 involved in several pathways and played different roles in them. We selected most pathways HTR4 participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
GRIN2A; SLC8A1; CALML3; PLCD3A; ERBB4A; PRKACBA; TACR1A; P2RX2; PRKCB; LHCGR
cAMP signaling pathway
HTR1B; PPP1CA; GHRL; PTGER3; HCAR3; FFAR2; PIK3CA; GRIA2; GABBR1; LOC100328615
Neuroactive ligand-receptor interaction
GRM3; TACR3; GCGR; MLNR; CGNRH-R; CALCRLA; NMUR1; LHB; GABRA2; TAAR10D
Serotonergic synapse
CYP2C54; PRKACB; MAOA; ALOX5; GNG4; HTR2C; GNG13; HTR1E; HTR6; HTR2A

Protein Function

HTR4 has several biochemical functions, for example, serotonin receptor activity, NOT trace-amine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR4 itself. We selected most functions HTR4 had, and list some proteins which have the same functions with HTR4. You can find most of the proteins on our site.
Function
Related Protein
Function serotonin receptor activity
Related Protein HTR1B; HTR1AB; HTR4; HTR2CL1; HTR1F; HTR3E; HTR6; HTR7; HTR2B; HTR2A
Function NOT trace-amine receptor activity
Related Protein HTR4

Interacting Protein

HTR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR4.
serotonin; gr 113808; ADRB2