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Official Full Name hyaluronoglucosaminidase 1
Background This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms HYAL1; hyaluronoglucosaminidase 1; hyaluronidase-1; FUS2; HYAL 1; LUCA1; NAT6; Hyal-1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; Lung carcinoma protein 1; MGC45987; Plasma hyaluronidase; Tumor suppressor LUCA 1; tumor suppressor LUCA-1
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rat
    • Source :
    • Bovine Testis
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HYAL1-12H Recombinant Human HYAL1 protein, His-tagged HEK293 His
    Human HYAL1-13H Recombinant Human HYAL1 protein, His-tagged CHO His
    Human HYAL1-1595H Recombinant Human HYAL1 protein, His-tagged E.coli His
    Human HYAL1-29413TH Recombinant Human HYAL1 Wheat Germ N/A
    Human HYAL1-29415TH Recombinant Human HYAL1 Wheat Germ N/A
    Human HYAL1-5223H Recombinant Human HYAL1 Protein, GST-tagged Wheat Germ GST
    Human HYAL1-5324HCL Recombinant Human HYAL1 293 Cell Lysate HEK293 N/A
    Human HYAL1-5325HCL Recombinant Human HYAL1 293 Cell Lysate HEK293 N/A
    Mouse Hyal1-1596M Recombinant Mouse Hyal1 protein, His-tagged E.coli His
    Mouse HYAL1-7952M Recombinant Mouse HYAL1 Protein Mammalian Cell His
    Rat Hyal1-1597R Recombinant Rat Hyal1 protein, His & T7-tagged E.coli His/T7
    Rat HYAL1-2975R Recombinant Rat HYAL1 Protein Mammalian Cell His
    Bovine HYAL1-39B Native Bovine Hyaluronidase Bovine Testis N/A

    HYAL1 involved in several pathways and played different roles in them. We selected most pathways HYAL1 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan degradation HYAL3; NAGLU; HYAL4; HYAL6; HYAL2; GNSA; IDS; HEXB; SGSH; GLB1
    Metabolic pathways TPH2; QDPRA; PTGES2; ODC1; CYP2U1; NAT; FTCD; CHPT1; MMAB; POLG2

    HYAL1 has several biochemical functions, for example, hyaluronan synthase activity, hyalurononglucosaminidase activity, NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL1 itself. We selected most functions HYAL1 had, and list some proteins which have the same functions with HYAL1. You can find most of the proteins on our site.

    Function Related Protein
    hyaluronan synthase activity HAS3; HAS2; HYAL1; HAS1
    hyalurononglucosaminidase activity HYAL4; KIAA1199; MGEA5; SPAM1; CD44; HYAL2; HYAL3; HYAL6; HYAL1
    NOT hyalurononglucosaminidase activity HYAL2; HYAL3; HYAL1
    transcription factor binding TFDP1A; CAMTA2; SOX10; NFATC4; TNFRSF10A; PAX2; SMARCD3; KLF5; E2F4; NFKBIA
    NOT virus receptor activity HYAL3; HYAL1

    HYAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL1.


    Schmaus, A; Sleeman, JP; et al. Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid. GLYCOBIOLOGY 25:258-268(2015).
    Colombaro, V; Jadot, I; et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. ACTA HISTOCHEMICA 117:83-91(2015).

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