hyal1
Share
  • Official Full Name
  • hyaluronoglucosaminidase 1
  • Background
  • This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HYAL1; hyaluronoglucosaminidase 1; hyaluronidase-1; FUS2; HYAL 1; LUCA1; NAT6; Hyal-1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; Lung carcinoma protein 1; MGC45987; Plasma hyaluronidase; Tumor suppressor LUCA 1; tumor suppressor LUCA-1
Cat.#:HYAL1-5223HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HYAL1 Protein, GST-tagged
+Inquiry
Cat.#:HYAL1-12HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HYAL1 protein, His-tagged
+Inquiry
Cat.#:HYAL1-13HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HYAL1 protein, His-tagged
+Inquiry
Cat.#:HYAL1-1595HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HYAL1 protein, His-tagged
+Inquiry
Cat.#:HYAL1-29413THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HYAL1
+Inquiry
Cat.#:HYAL1-29415THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HYAL1
+Inquiry
Cat.#:Hyal1-1596MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hyal1 protein, His-tagged
+Inquiry
Cat.#:HYAL1-7952MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HYAL1 Protein
+Inquiry
Cat.#:Hyal1-1597RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hyal1 protein, His & T7-tagged
+Inquiry
Cat.#:HYAL1-2975RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HYAL1 Protein
+Inquiry
Cat.#:HYAL1-39BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Hyaluronidase
+Inquiry
Cat.#:HYAL1-5324HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HYAL1 293 Cell Lysate
+Inquiry
Cat.#:HYAL1-5325HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HYAL1 293 Cell Lysate
+Inquiry

Involved Pathway

HYAL1 involved in several pathways and played different roles in them. We selected most pathways HYAL1 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
SPAM1; GNSA; HPSE; HYAL2; GNSB; GLB1; HYAL1; GNS; GALNS; IDUA
Metabolic pathways
COX8C; MPST; MGAT5B; POLR2E; OGDHL; GATB; SDHA; AUH; NADKD1; DAO
Lysosome
ATP6V0C; ASAH1B; PLA2G15; MANBA; GNSA; CTSA; TPP1; CTPS1B; ASAH1; Abca2

Protein Function

HYAL1 has several biochemical functions, for example, hyaluronan synthase activity, hyalurononglucosaminidase activity, NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL1 itself. We selected most functions HYAL1 had, and list some proteins which have the same functions with HYAL1. You can find most of the proteins on our site.
Function
Related Protein
Function hyaluronan synthase activity
Related Protein HAS1; HYAL1; HAS3; HAS2
Function hyalurononglucosaminidase activity
Related Protein HYAL6; KIAA1199; HYAL4; HYAL1; HYAL3; CD44; MGEA5; HYAL2; SPAM1
Function NOT hyalurononglucosaminidase activity
Related Protein HYAL2; HYAL3; HYAL1
Function transcription factor binding
Related Protein TAF12; TRIM11; PAXBP1; HES4; RBL1; ARID5A; PRICKLE1; UBA2; FIGLA; KCNA3
Function NOT virus receptor activity
Related Protein HYAL1; HYAL3

Interacting Protein

HYAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL1.
COL2A1

HYAL1 Related Articles

Schmaus, A; Sleeman, JP; et al. Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid. GLYCOBIOLOGY 25:258-268(2015).
Colombaro, V; Jadot, I; et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. ACTA HISTOCHEMICA 117:83-91(2015).