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HYAL1

  • Official Full Name

    hyaluronoglucosaminidase 1

  • Overview

    This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HYAL1; hyaluronoglucosaminidase 1; hyaluronidase-1; FUS2; HYAL 1; LUCA1; NAT6; Hyal-1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; Lung carcinoma protein 1; MGC45987; Plasma hyaluronidase; Tumor suppressor LUCA 1; tumor suppressor LUCA-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Human
  • Mouse
  • Rat
  • Bovine Testis
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HYAL1-13H Active Recombinant Human HYAL1 protein, His-tagged CHO His
Human HYAL1-11HFL Active Recombinant Full Length Human HYAL1 Protein, C-6×His tagged CHO C-6×His
Human HYAL1-29415TH Recombinant Human HYAL1 Wheat Germ N/A 253 amino acids
Human HYAL1-29413TH Recombinant Human HYAL1 Wheat Germ N/A 100 amino acids
Human HYAL1-12H Recombinant Human HYAL1 protein, His-tagged HEK293 His
Human HYAL1-5324HCL Recombinant Human HYAL1 293 Cell Lysate HEK293 N/A
Human HYAL1-5325HCL Recombinant Human HYAL1 293 Cell Lysate HEK293 N/A
Human HYAL1-2506H Recombinant Human HYAL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HYAL1-1595H Recombinant Human HYAL1 protein, His-tagged E.coli His Phe22~Trp435 (Accession # Q12794)
Human HYAL1-2264H Recombinant Human HYAL1 Protein, His-tagged E.coli N-His Phe201-Trp435
Human HYAL1-002H Recombinant Human HYAL1 Protein, His-tagged HEK293 His 22-435
Human HYAL1-5761H Recombinant Human HYAL1 protein, His-tagged Yeast His 22-435aa
Human HYAL1-247HF Active Recombinant Full Length Human HYAL1 Protein In Vitro Cell Free System 253 amino acids
Human HYAL1-3466H Recombinant Human HYAL1 Protein (Phe22-Trp435), C-His tagged Mammalian cells C-His Phe22-Trp435
Human HYAL1-3467H Recombinant Human HYAL1 Protein (Phe22-Trp435), His tagged E.coli His Phe22-Trp435
Mouse HYAL1-7952M Recombinant Mouse HYAL1 Protein Mammalian Cell His
Mouse HYAL1-4388M-B Recombinant Mouse HYAL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HYAL1-4388M Recombinant Mouse HYAL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hyal1-1596M Recombinant Mouse Hyal1 protein, His-tagged E.coli His Gly52~Met462 (Accession # Q91ZJ9)
Rat HYAL1-2975R Recombinant Rat HYAL1 Protein Mammalian Cell His
Rat HYAL1-2630R-B Recombinant Rat HYAL1 Protein Pre-coupled Magnetic Beads HEK293
Rat HYAL1-2630R Recombinant Rat HYAL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hyal1-1597R Recombinant Rat Hyal1 protein, His & T7-tagged E.coli His/T7 Ser40~Met449 (Accession # Q76HN1)
Bovine HYAL1-39B Active Native Bovine Hyaluronidase Bovine Testis N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HYAL1 Related Articles
  • HYAL1 Related Research Area

HYAL1 involved in several pathways and played different roles in them. We selected most pathways HYAL1 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan degradationHYAL3;IDS;GLB1;SGSH;HGSNAT;GUSB;GNS;HYAL1;HPSE
Metabolic pathwaysTSTA3;COQ6;PIP5K1BA;PTGESL;POLR1D;PANK1;ATP6AP1B;PDHB;SC5D
LysosomeARSA;SLC11A1;SMPD1;ATP6V0B;ATP6AP1B;LAMP3;GBA;ASAH1;SLC11A2

HYAL1 has several biochemical functions, for example, hyaluronan synthase activity, hyalurononglucosaminidase activity, NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL1 itself. We selected most functions HYAL1 had, and list some proteins which have the same functions with HYAL1. You can find most of the proteins on our site.

Function Related Protein
hyaluronan synthase activityHAS2;HAS1;HYAL1;HAS3
hyalurononglucosaminidase activityHYAL3;HYAL2;SPAM1;HYAL4;KIAA1199;MGEA5;HYAL6;HYAL1;CD44
NOT hyalurononglucosaminidase activityHYAL3;HYAL2;HYAL1
transcription factor bindingPOU1F1;NFYC;ZEB1;NFKB1;DNMT1;NKX2-1;RB1;INSIG2;JUN
NOT virus receptor activityHYAL3;HYAL1

HYAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL1.

COL2A1

Schmaus, A; Sleeman, JP; et al. Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid. GLYCOBIOLOGY 25:258-268(2015).
Colombaro, V; Jadot, I; et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. ACTA HISTOCHEMICA 117:83-91(2015).
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