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ICAM4

  • Official Full Name

    intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

  • Overview

    This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms

    ICAM4; intercellular adhesion molecule 4 (Landsteiner-Wiener blood group); intercellular adhesion molecule 4 (LW blood group) , intercellular adhesion molecule 4, Landsteiner Wiener blood group , Landsteiner Wiener blood group , LW; intercellular adhesion molecule 4; CD242; CD242 antigen; ICAM-4; ICAM4_HUMAN; Landsteiner Wiener blood group glycoprotein; Landsteiner-Wiener blood group glycoprotein; LW; LW blood group protein; Landsteiner-Wiener blood group antigen a; intercellular adhesion molecule 4 (LW blood group);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian cells
  • C
  • His
  • Fc|His
  • Flag
  • GST|His
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ICAM4-289H Recombinant Human ICAM4, Fc tagged Human Cell Fc/His
Human ICAM4-204H Recombinant Human ICAM4 Protein, GST-His-tagged E.coli GST/His
Human ICAM4-943HCL Recombinant Human ICAM4 cell lysate Human Cell N/A
Human ICAM4-4077H Recombinant Human ICAM4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ICAM4-795H Recombinant Human ICAM4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ICAM4-061H Recombinant Human ICAM4 Protein, His-tagged E.coli His
Human ICAM4-1357HFL Recombinant Full Length Human ICAM4 Protein, C-Flag-tagged Mammalian cells Flag
Human ICAM4-1130H-B Recombinant Human ICAM4 Protein Pre-coupled Magnetic Beads HEK293
Human ICAM4-3215H Recombinant Human ICAM4 protein, His-tagged E.coli His 23-152 aa
Human ICAM4-1255H Recombinant Human ICAM4 Protein (Met52-Trp234), N-His tagged E.coli N-His Met52-Trp234
Human ICAM4-1130H Recombinant Human ICAM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ICAM4-2169H Recombinant Human ICAM4 protein, hFc-tagged HEK293 hFc Met1-Gly272
Human ICAM4-4247H Recombinant Human ICAM4 Protein (Met1-Ala240), C-His tagged Mammalian cells C-His Met1-Ala240
Mouse Icam4-7128M Recombinant Mouse Icam4 protein, His & T7-tagged E.coli His/T7 Gln23~Leu227 (Accession # Q9ERM2)
Mouse Icam4-4877M Recombinant Mouse Icam4 protein, His-SUMO-tagged E.coli His-SUMO 23-231aa
Mouse Icam4-3469M Recombinant Mouse Icam4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Icam4-7129R Recombinant Rat Icam4 protein, His & T7-tagged E.coli His/T7 Ala32~Ala226 (Accession # D3ZP29)
Rhesus monkey ICAM4-1621R Recombinant Rhesus Monkey ICAM4 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey ICAM4-1619R Recombinant Rhesus Monkey ICAM4 Protein HEK293 N/A
Rhesus monkey ICAM4-1620R Recombinant Rhesus Monkey ICAM4 Protein, hIgG1-tagged HEK293 hIgG1
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ICAM4 Related Articles
  • ICAM4 Related Research Area

ICAM4 involved in several pathways and played different roles in them. We selected most pathways ICAM4 participated on our site, such as Adaptive Immune System, Extracellular matrix organization, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemARIH2;AP2S1;GRAP2B;TRIM69;TPP2;ASB9;KLRB1B;SH2D1B;AKT3
Extracellular matrix organizationFBLN1;LRP4;ADAM8;ADAMTS18;CEACAM6;MMP19;COL5A3B;COMP;LOXL4
Immune SystemCASPB;TNFRSF13C;TNRC5;CASPBL;GBP5;CD180;CRP;CISH;KIFAP3
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellSIGLEC11;CD200R2;CD300LH;SIGLEC12;CXADR;NCR3LG1;CLEC2G;AMICA1;LILRB1
Integrin cell surface interactionsFN1B;F11R.2;COL13A1;ICAM4;JAM2B;COL9A1B;LOC100514666;COMP;FBN1

ICAM4 has several biochemical functions, for example, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM4 itself. We selected most functions ICAM4 had, and list some proteins which have the same functions with ICAM4. You can find most of the proteins on our site.

Function Related Protein
integrin bindingCOL4A3;TNN;ITGB1;AMICA1;ESM1;PPAP2B;ANXA7;ADAM17;EMP2
protein bindingGLP1R;ALOX12B;SULT4A1;BAG5;FKBP7;COG7;CALCOCO1;CHMP1B;FCGR1A

ICAM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM4.

CREB3; IGHG1

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Rosette, C; Roth, RB; et al. Role of ICAM1 in invasion of human breast cancer cells. CARCINOGENESIS 26:943-950(2005).
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