icam4
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  • Official Full Name
  • intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  • Background
  • This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • ICAM4; intercellular adhesion molecule 4 (Landsteiner-Wiener blood group); intercellular adhesion molecule 4 (LW blood group) , intercellular adhesion molecule 4, Landsteiner Wiener blood group , Landsteiner Wiener blood group , LW; intercellular adhesion molecule 4; CD242; CD242 antigen; ICAM-4; ICAM4_HUMAN; Landsteiner Wiener blood group glycoprotein; Landsteiner-Wiener blood group glycoprotein; LW; LW blood group protein; Landsteiner-Wiener blood group antigen a; intercellular adhesion molecule 4 (LW blood group)
Cat.#:ICAM4-795HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM4 Protein, MYC/DDK-tagged
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Cat.#:ICAM4-204HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICAM4 Protein, GST-His-tagged
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Cat.#:ICAM4-289HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM4, Fc tagged
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Cat.#:Icam4-7128MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Icam4 protein, His & T7-tagged
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Cat.#:Icam4-7129RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Icam4 protein, His & T7-tagged
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Cat.#:ICAM4-1619RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM4 Protein
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Cat.#:ICAM4-1620RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM4 Protein, hIgG1-tagged
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Cat.#:ICAM4-1621RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ICAM4 Protein, hIgG4-tagged
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Cat.#:ICAM4-943HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ICAM4 cell lysate
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Involved Pathway

ICAM4 involved in several pathways and played different roles in them. We selected most pathways ICAM4 participated on our site, such as Adaptive Immune System, Extracellular matrix organization, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SLAMF6; HBEGF; ASB3; CMTM2A; CRTAM; RAP1GAP2B; STIM1B; CTSH; CTSK; CD300LF
Extracellular matrix organization
CTRB1; PCOLCEB; JAM2B; FBN2; ADAM8A; BSG; COL28A1; COL9A1B; CTSB; COL9A1A
Immune System
DYNC1I2; FCN3; GAN; PJA1; MX2; HAVCR2; ERAP1; ACTR2B; TREML2; ASB3
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TREML2; NCR3LG1; CD300LD; ICAM4; KLRB1A; LILRB3; LAIR1; LILRB4; MICA; CD300LB
Integrin cell surface interactions
JAM2B; COL9A1A; F11R.2; COL23A1; COL16A1; BSG; COL13A1; COL9A1B; FN1B; LOC100514666

Protein Function

ICAM4 has several biochemical functions, for example, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM4 itself. We selected most functions ICAM4 had, and list some proteins which have the same functions with ICAM4. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein ICAM5; GPNMB; CIB2; WISP1A; FBN1; ANXA7; NISCH; FAP; ACTN1; ANGPTL3
Function protein binding
Related Protein AMBRA1; TMIGD2; ASB2; MST1R; TSHR; RHOA; GZMB; PSMD6; PTPRE; ZNF34

Interacting Protein

ICAM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM4.
CREB3; IGHG1

ICAM4 Related Articles

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Rosette, C; Roth, RB; et al. Role of ICAM1 in invasion of human breast cancer cells. CARCINOGENESIS 26:943-950(2005).