il6ra
Share
  • Official Full Name
  • interleukin 6 receptor, alpha
  • Background
  • This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9.
  • Synonyms
  • IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; gp80; CD 126; CD126; CD126 antigen; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA_HUMAN; Interleukin 6 receptor; Membrane glycoprotein 80; IL-6 receptor alpha chain; IL-6R
Cat.#:IL6RA-3322HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IL6RA protein
+Inquiry
Cat.#:IL6RA-3324HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human IL6RA protein
+Inquiry
Cat.#:IL6RA-345HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6RA Protein, Fc-tagged
+Inquiry
Cat.#:Il6ra-001MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL6RA, MIgG2a Fc-tagged
+Inquiry
Cat.#:Il6ra-2297MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il6ra, His tagged
+Inquiry
Cat.#:Il6ra-583MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il6ra protein, His-tagged
+Inquiry
Cat.#:IL6RA-8178MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL6RA Protein
+Inquiry
Cat.#:IL6RA-3467CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL6RA
+Inquiry
Cat.#:IL6R-2590MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL6R cell lysate
+Inquiry

Involved Pathway

Il6ra involved in several pathways and played different roles in them. We selected most pathways Il6ra participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNGR1; LEPB; Cxcl15; CSF3; IL10; IL28RA; IL18R1; FAS; AMHR2; TNFRSF17
HIF- signaling pathway
INSR; PDHA1; PIK3R1; PLCG1; PIK3R5; TCEB2; ERBB2; HMOX1; SERPINE1; VEGFA
PIK-Akt signaling pathway
PPP2R2B; IL4; GYS1; ITGA2; Il4ra; HSP90B1; LAMB4; CREB5; YWHAZ; LPAR6
Jak-STAT signaling pathway
NT5C3; IFNW1; IL17D; IFNA12; IL22RA2; IFNA5; CRFB16; IL24; IL12RB1; PIM1
Hematopoietic cell lineage
THPO; Itga10&Itgb1; ANPEP; Itgam&Itgb2; CD36; ITGA3; IL5RA; FLT3; MS4A1; CD1D
Non-alcoholic fatty liver disease (NAFLD)
SREBF1; IL-8; PIK3CA; ATF4; INSR; INS2; LEPR; MAPK10; CEBPA; PRKAB2

Protein Function

Il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6ra itself. We selected most functions Il6ra had, and list some proteins which have the same functions with Il6ra. You can find most of the proteins on our site.
Function
Related Protein
Function ciliary neurotrophic factor binding
Related Protein IL6R; Il6ra
Function contributes_to ciliary neurotrophic factor receptor activity
Related Protein IL6R; LIFR; Il6ra; CNTFR
Function cytokine receptor activity
Related Protein CSF3R; CD74; IL31RA; CRFB16; IL20RA; CRFB15; IRX1; IL21R.2; IL2RGA; CRFB17
Function enzyme binding
Related Protein RCOR3; NOXA1; PEX7; Slc4a2; HDAC2; RAD9A; LAMP1; MST1R; TRIO; TOP2A
Function interleukin-6 binding
Related Protein IL6R; Il6ra
Function interleukin-6 receptor activity
Related Protein Il6ra
Function contributes_to interleukin-6 receptor activity
Related Protein IL6ST; IL6R; Il6ra
Function contributes_to interleukin-6 receptor binding
Related Protein IL6; IL6R; Il6ra; IL6ST
Function protein homodimerization activity
Related Protein ZFP423; WWTR1; RAB11FIP4B; PDGFC; TYRP1; GRHPR; BNIP3; OLFM4; IMPA2; VEGFB

Interacting Protein

Il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6ra.
Il6st

Il6ra Related Gene Family

IL