impa1
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  • Official Full Name
  • inositol(myo)-1(or 4)-monophosphatase 1
  • Background
  • This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
  • Synonyms
  • IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMP; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1;
Cat.#:IMPA1-5144HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IMPA1 Protein, GST-tagged
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Cat.#:IMPA1-2824HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA1, His-tagged
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Cat.#:IMPA1-29490THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA1, His-tagged
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Cat.#:IMPA1-318HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA1, His-tagged
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Cat.#:IMPA1-720HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IMPA1 Protein, His-tagged
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Cat.#:IMPA1-3056RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IMPA1 Protein
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Cat.#:IMPA1-841ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IMPA1
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Cat.#:IMPA1-5214HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IMPA1 293 Cell Lysate
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Involved Pathway

IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
INPP5B; ITPK1; INPP4AB; PLCB4; PIK3C3; MINPP1A; MTMR14; PIK3C2A; PIP5K1A; ISYNA1
Metabolic pathways
PNP6; ATP6V0CA; NMNAT2; LALBA; GAPDH; Atp5k; AANAT2; B3GNTL2; AK2; CYP7A1A
Phosphatidylinositol signaling system
INPP4B; IP6K3; PIK3R3A; PI4K2B; DGKD; MTMR14; MTMR1A; MTMR1B; ITPKB; PIP5K1AA

Protein Function

IMPA1 has several biochemical functions, for example, identical protein binding, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein G6PDX; ATXN10; SYP; CLDN23; POLG2; CST3; CREBZF; ST13; PTK6; KHDRBS1
Function inositol monophosphate 1-phosphatase activity
Related Protein IMPAD1; IMPA2; IMPA1
Function inositol monophosphate 3-phosphatase activity
Related Protein IMPA1; IMPAD1; IMPA2
Function inositol monophosphate 4-phosphatase activity
Related Protein IMPA1; IMPAD1; IMPA2
Function inositol monophosphate phosphatase activity
Related Protein IMPA1
Function lithium ion binding
Related Protein PDXK; IMPA1
Function magnesium ion binding
Related Protein TSSK2; TSSK3; BPNT1; PTENA; FDXACB1; RPS6KA6; PPM1NB; MTHFD2; S100P; PRPSAP1
Function manganese ion binding
Related Protein MTPAP; LAP3; NPEPL1; FAM20C; PPM1B; DYRK2; GALNT2; ME1; HMGCL; PIM1
Function protein binding
Related Protein OTOF; CDK18; FAAH; RYR1; RPLP1; CYP4F2; WDR4; FAM9C; YIPF3; CYBB
Function protein homodimerization activity
Related Protein WHRN; CHMP4A; S100A11; ABCG1; AP1S2; NADK2; IMPA1; BLOC1S6; PVRL3B; ABCD2

Interacting Protein

IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.
IMPA2; Impa1; E2F3

IMPA1 Related Articles

Sacchi, R; Gardell, AM; et al. Osmotic Regulation and Tissue Localization of the Myo-Inositol Biosynthesis Pathway in Tilapia (Oreochromis mossambicus) Larvae. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY 321:457-466(2014).
Sade, Y; Kara, NZ; et al. Beware of your mouse strain; differential effects of lithium on behavioral and neurochemical phenotypes in Harlan ICR mice bred in Israel or the USA. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124:36-39(2014).