|Official Full Name||inositol(myo)-1(or 4)-monophosphatase 1|
|Background||This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]|
|Synonyms||IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMP; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Inositol phosphate metabolism||PIP5KL1; MTMR6; PI4K2B; INPP5E; MTMR7A; PLCD3A; MINPP1; PIP5K1AB; INPP5D; PLCG1|
|Metabolic pathways||FAM213B; ALDH9A1; CYP4F3; CYP2P6; AOC1; B3GNT4; G6PC2; POLR2J; POLR2J2; NME7|
|Phosphatidylinositol signaling system||INPP5A; PRKCG; ITPKA; INPPL1A; MTMR7B; PIK3R3B; CALM2; PIP5K1AA; PIP4K2A; PLCD1B|
IMPA1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.
|identical protein binding||CEP72; DAAM1; DIAPH1; EGFR; ACPP; CCDC109A; TNPO3; TPRG1L; HSD17B10; PRC1|
|inositol monophosphate 1-phosphatase activity||IMPA1; IMPA2; IMPAD1|
|inositol monophosphate 3-phosphatase activity||IMPAD1; IMPA2; IMPA1|
|inositol monophosphate 4-phosphatase activity||IMPA1; IMPA2; IMPAD1|
|inositol monophosphate phosphatase activity||IMPA1|
|lithium ion binding||PDXK; IMPA1|
|magnesium ion binding||RPS6KAL; FIGNL1; IRAK3; RPS6KA4; MAST4; HACL1; MAST2; FDXACB1; GLUL; IDH2|
|manganese ion binding||PIM1; PPEF1; NUDT16; PRIMPOL; DYRK2; SOD2; PPM1AA; PPM1N; LARGE; WRN|
|protein binding||TLR6; C8orf74; PRR13; TIMM10; MAP2K2; HLA-A; CD8B1; RAD9A; CUEDC2; LSM7|
|protein homodimerization activity||TLR13; BNIP3; SYT6; SLC4A1; UPK1A; TFAP4; NR2F2; SRM; ABCG2; MYO7A|
IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.
IMPA2; Impa1; E2F3