IMPA1

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IMPA1

Official Full Name inositol(myo)-1(or 4)-monophosphatase 1
Background This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
Synonyms IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMP; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1;
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IMPA1-2824H Recombinant Human IMPA1, His-tagged E.coli His
    Human IMPA1-29490TH Recombinant Human IMPA1, His-tagged E.coli His
    Human IMPA1-318H Recombinant Human IMPA1, His-tagged E.coli His
    Human IMPA1-5144H Recombinant Human IMPA1 Protein, GST-tagged Wheat Germ GST
    Human IMPA1-5214HCL Recombinant Human IMPA1 293 Cell Lysate HEK293 N/A
    Human IMPA1-720H Recombinant Human IMPA1 Protein, His-tagged E.coli His
    Rat IMPA1-3056R Recombinant Rat IMPA1 Protein Mammalian Cell His
    Zebrafish IMPA1-841Z Recombinant Zebrafish IMPA1 Mammalian Cell His

    IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PIP5KL1; MTMR6; PI4K2B; INPP5E; MTMR7A; PLCD3A; MINPP1; PIP5K1AB; INPP5D; PLCG1
    Metabolic pathways FAM213B; ALDH9A1; CYP4F3; CYP2P6; AOC1; B3GNT4; G6PC2; POLR2J; POLR2J2; NME7
    Phosphatidylinositol signaling system INPP5A; PRKCG; ITPKA; INPPL1A; MTMR7B; PIK3R3B; CALM2; PIP5K1AA; PIP4K2A; PLCD1B

    IMPA1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding CEP72; DAAM1; DIAPH1; EGFR; ACPP; CCDC109A; TNPO3; TPRG1L; HSD17B10; PRC1
    inositol monophosphate 1-phosphatase activity IMPA1; IMPA2; IMPAD1
    inositol monophosphate 3-phosphatase activity IMPAD1; IMPA2; IMPA1
    inositol monophosphate 4-phosphatase activity IMPA1; IMPA2; IMPAD1
    inositol monophosphate phosphatase activity IMPA1
    lithium ion binding PDXK; IMPA1
    magnesium ion binding RPS6KAL; FIGNL1; IRAK3; RPS6KA4; MAST4; HACL1; MAST2; FDXACB1; GLUL; IDH2
    manganese ion binding PIM1; PPEF1; NUDT16; PRIMPOL; DYRK2; SOD2; PPM1AA; PPM1N; LARGE; WRN
    protein binding TLR6; C8orf74; PRR13; TIMM10; MAP2K2; HLA-A; CD8B1; RAD9A; CUEDC2; LSM7
    protein homodimerization activity TLR13; BNIP3; SYT6; SLC4A1; UPK1A; TFAP4; NR2F2; SRM; ABCG2; MYO7A

    IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.

    IMPA2; Impa1; E2F3

    Sacchi, R; Gardell, AM; et al. Osmotic Regulation and Tissue Localization of the Myo-Inositol Biosynthesis Pathway in Tilapia (Oreochromis mossambicus) Larvae. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY 321:457-466(2014).
    Sade, Y; Kara, NZ; et al. Beware of your mouse strain; differential effects of lithium on behavioral and neurochemical phenotypes in Harlan ICR mice bred in Israel or the USA. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124:36-39(2014).

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