inpp5e
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  • Official Full Name
  • inositol polyphosphate-5-phosphatase, 72 kDa
  • Background
  • The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.
  • Synonyms
  • INPP5E; inositol polyphosphate-5-phosphatase, 72 kDa; JBTS1, Joubert syndrome 1; 72 kDa inositol polyphosphate 5-phosphatase; CORS1; PPI5PIV; Inositol polyphosphate 5 phosphatase; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase; Phosphatidylinositol polyphosphate 5 phosphatase type IV; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV; CPD4; JBTS1; MORMS
Cat.#:INPP5E-2396HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human INPP5E Protein, MYC/DDK-tagged
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Cat.#:INPP5E-5105HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INPP5E Protein, GST-tagged
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Cat.#:INPP5E-2276RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey INPP5E Protein, His-tagged
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Cat.#:INPP5E-5933ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish INPP5E
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Cat.#:INPP5E-862HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human INPP5E cell lysate
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Involved Pathway

INPP5E involved in several pathways and played different roles in them. We selected most pathways INPP5E participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIP5K1B; PIP5K1A; IMPAD1; PTENA; PLCG1; OCRL; PLCB4; PLCD4; ISYNA1; PLCB2
Metabolic pathways
MT-ND4; PIGM; LIPCA; CYP2C37; B3GNT5B; G6PCA.1; POLR1B; HLCS; UGT8A; POLA2
Phosphatidylinositol signaling system
PIP5K1BA; INPP5J; PPIP5K1; INPP5A; MTMR1; PIK3C2A; PLCD4; IP6K2; CALM; PLCB3

Protein Function

INPP5E has several biochemical functions, for example, inositol-polyphosphate 5-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5E itself. We selected most functions INPP5E had, and list some proteins which have the same functions with INPP5E. You can find most of the proteins on our site.
Function
Related Protein
Function inositol-polyphosphate 5-phosphatase activity
Related Protein INPPL1; INPP5J; INPP5E; INPP5K; INPP5D; INPP5A
Function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Related Protein OCRL; INPP5B; PTPMT1; INPP5E; EPM2A; SYNJ2

INPP5E Related Articles

Kong, AM; Speed, CJ; et al. Cloning, and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. JOURNAL OF BIOLOGICAL CHEMISTRY 275:24052-24064(2000).
ROSS, TS; JEFFERSON, AB; et al. CLONING AND EXPRESSION OF HUMAN 7K-KDA INOSITOL POLYPHOSPHATE-5-PHOSPHATASE. JOURNAL OF BIOLOGICAL CHEMISTRY 266:20283-20289(1991).