Recombinant Full Length Human INPP5E Protein, C-Flag-tagged
Cat.No. : | INPP5E-489HFL |
Product Overview : | Recombinant Full Length Human INPP5E Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 70 kDa |
AA Sequence : | MPSKAENLRPSEPAPQPPEGRTLQG QLPGAPPAQRAGSPPDAPGSESPAL ACSTPATPSGEDPPARAAPI APRPPARPRLERALSLDDKGWRRRR FRGSQEDLEARNGTSPSRGSVQSEG PGAPAHSCSPPCLSTSLQEI PKSRGVLSSERGSPSSGGNPLSGVA SSSPNLPHRDAAVAGSSPRLPSLLP PRPPPALSLDIASDSLRTAN KVDSDLADYKLRAQPLLVRAHSSLG PGRPRSPLACDDCSLRSAKSSFSLL APIRSKDVRSRSYLEGSLLA SGALLGADELARYFPDRNVALFVAT WNMQGQKELPPSLDEFLLPAEADYA QDLYVIGVQEGCSDRREWET RLQETLGPHYVLLSSAAHGVLYMSL FIRRDLIWFCSEVECSTVTTRIVSQ IKTKGALGISFTFFGTSFLF ITSHFTSGDGKVAERLLDYTRTVQA LVLPRNVPDTNPYRSSAADVTTRFD EVFWFGDFNFRLSGGRTVVD ALLCQGLVVDVPALLQHDQLIREMR KGSIFKGFQEPDIHFLPSYKFDIGK DTYDSTSKQRTPSYTDRVLY RSRHKGDICPVSYSSCPGIKTSDHR PVYGLFRVKVRPGRDNIPLAAGKFD RELYLLGIKRRISKEIQRQQ ALQSQNSSTICSVSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system |
Gene Name : | INPP5E inositol polyphosphate-5-phosphatase E [ Homo sapiens (human) ] |
Official Symbol : | INPP5E |
Synonyms : | CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin |
Gene ID : | 56623 |
mRNA Refseq : | NM_019892.6 |
Protein Refseq : | NP_063945.2 |
MIM : | 613037 |
UniProt ID : | Q9NRR6 |
Products Types
◆ Recombinant Protein | ||
INPP5E-2097R | Recombinant Rhesus Macaque INPP5E Protein, His (Fc)-Avi-tagged | +Inquiry |
INPP5E-5105H | Recombinant Human INPP5E Protein, GST-tagged | +Inquiry |
Inpp5e-3548M | Recombinant Mouse Inpp5e Protein, Myc/DDK-tagged | +Inquiry |
INPP5E-2396H | Recombinant Human INPP5E Protein, MYC/DDK-tagged | +Inquiry |
INPP5E-1186H | Recombinant Human INPP5E Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
INPP5E-862HCL | Recombinant Human INPP5E cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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