irs1
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  • Official Full Name
  • insulin receptor substrate 1
  • Background
  • This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
  • Synonyms
  • IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;
Cat.#:IRS1-12HCLTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IRS1 HEK293T cell lysate
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Cat.#:IRS1-1466HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Insulin Receptor Substrate 1, GST-tagged
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Cat.#:IRS1-28643THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRS1
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Cat.#:IRS1-28726THTag:
Source (Host):Species:Human
Product nameRecombinant Human IRS1
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Cat.#:Irs1-7871MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irs1 protein, His & T7-tagged
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Cat.#:IRS1-8313MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRS1 Protein
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Cat.#:IRS1-3099RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IRS1 Protein
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Cat.#:IRS1-3212CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRS1
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Cat.#:IRS1-1467HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin Receptor Substrate 1, GST-tagged
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Cat.#:IRS1-872HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRS1 cell lysate
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Involved Pathway

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
GTF2I; PDE3A; PLCB1; ATP1B4; PPP3CB; INS; GNAI1; ITPR1; CALM1; GNAI2
FoxO signaling pathway
SGK2; STK11; GABARAPA; SOS1; KLF2; SIRT1; HOMER1B; STAT3; S1PR1; MAPK9
mTOR signaling pathway
INS1; TSC1A; STK11; AKT2; TSC2; RPS6KB1; RRN3; STRADA; AKT3A; RPS6KA1
PIK-Akt signaling pathway
GNB3; TCL1B4; RPTOR; RAF1; COL24A1; GNGT1; ANGPT2; FGF9; PTK2; CREB3L3
AMPK signaling pathway
FOXO3; FBP1; PPP2R5B; EIF4EBP1; PFKFB2; INS; CAB39L; AKT3; EEF2; CPT1A
Neurotrophin signaling pathway
MAPK12; NGFR; MAPK8; MAP2K2; CALML3; PIK3CB; RAP1A; RAC1; PIK3CG; SORT1
Insulin signaling pathway
FBP1A; FOXO1B; PRKCZ; MKNK1; PRKAR2A; MAPK9; PDPK1B; PRKACAB; RPTOR; PHKB
Adipocytokine signaling pathway
RXRB; ACSL1B; IRS4; TNFRSF1B; LEPR; POMC; IKBKG; G6PC3; PRKCQ; ACSL4A
Regulation of lipolysis in adipocytes
IRS4; GNAS; NPY1R; TSHB; PIK3CG; PIK3R5; AQP7; NPY; INS1; AKT2
Type II diabetes mellitus
MAPK1; PIK3CB; INS2; INS; PKLR; PIK3CD; HK1; IRS2; SOCS3; SOCS4
Insulin resistance
PPARAB; NR1H2; PYGM; G6PC2; INS1; SLC27A1B; RPS6KA3B; PRKCQ; NR1H3; IL6
Non-alcoholic fatty liver disease (NAFLD)
PIK3R5; INSR; INS2; NDUFS1; NDUFA4; PRKAA2; NDUFS8; NDUFS4; NDUFB5; KCNA3
Aldosterone-regulated sodium reabsorption
ALPHA-ENAC; PIK3CD; ATP1B3; ATP1B2; SCNN1B; IGF1; PIK3R3; ATP1A2; SFN; NEDD4L
MicroRNAs in cancer
VIM; SHC1; STMN1; TRIM71; CDC25A; CCND1; BMI1; PDGFB; TNXB; PIK3R2

Protein Function

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.
Function
Related Protein
Function SH2 domain binding
Related Protein AFAP1L2; SRC; LAX1; PTK2; CRK; LAT2; SKAP1; MS4A2; GNB2L1; TRPV4
Function insulin receptor binding
Related Protein FRS2B; FRS2; DOK1B; SNX4; DOK3; IGF1; PTPN11; LMBRD1; DOK2; DOK1
Function insulin-like growth factor receptor binding
Related Protein YWHAH; SHC1; INSL4; IGF3; GNAS; IGF1; IGF2B; Ren1; IGF2A; YWHAG
Function phosphatidylinositol 3-kinase binding
Related Protein JAK2; PIK3R1; INSRR; IRS4; CALM1; FLT3; CORO1A; CALM2; ATP1A1; IGF1R
Function protein binding
Related Protein TRAPPC2L; IL1A; SEPT11; DCD; CYCS; STX11; TCEB2; KCTD15; SORL1; STXBP3A
Function protein kinase C binding
Related Protein SDPRB; TOP2A; DSP; HINT1; PARD6A; PICK1; ADAM9; C1QBP; AKT1; PAWR
Function signal transducer activity
Related Protein STAT1A; MRGPRB8; TRIM63; OPN4A; DKK1; ERG; TAS1R2.2; GHRHR2; OLFCG3; NPY8BR
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein GAB2; BLNK; FRS2; IRS1; TRAT1; SHC1; SH2B2; DOK2; STAP1; PIK3R1

Interacting Protein

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.
PIK3R1; PIK3CA

IRS1 Related Articles

Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).
Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).

IRS1 Related Gene Family

TGF