itgb2
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  • Official Full Name
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • Background
  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
  • Synonyms
  • 95 subunit beta; Beta 2 (antigen CD18 (p95); CD 18; CD18; CD18 antigen; Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor); Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150; Complement component 3 receptor 3 and 4 subunit; Complement receptor C3 beta subunit; Complement receptor C3 subunit beta; Integrin beta 2; Integrin beta chain beta 2; Integrin beta-2; Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2_HUMAN; ITGB 2; ITGB2; LAD; LCAMB; Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; LFA 1; LFA1; Lymphocyte function associated antigen 1; MAC 1; MAC1; Macrophage antigen 1 (mac1) beta subunit; MF17; MFI7; LFA-1; MAC-1
Cat.#:ITGB2-4978HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB2 Protein, GST-tagged
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Cat.#:ITGAM&ITGB2-692HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGAM&ITGB2
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Cat.#:ITGB2-181HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB2 protein, T7/His-tagged
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Cat.#:ITGB2-26324THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-26325THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-71HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ITGB2 protein, His-tagged
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Cat.#:Itgam&Itgb2-605MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Itgam&Itgb2
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Cat.#:Itgb2-7145MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgb2 protein, His & T7-tagged
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Cat.#:Itgb2-7146RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itgb2 protein, His & T7-tagged
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Cat.#:ITGB2-6803CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGB2
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Cat.#:ITGAX & ITGB2-1875HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAX & ITGB2 cell lysate
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Cat.#:ITGB2-5125HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGB2 293 Cell Lysate
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Cat.#:CSC-P0026Tag:
Source (Host):Species:
Product nameAnti-Human ITGB2 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0027Tag:
Source (Host):Species:
Product nameAnti-Human ITGB2 scFv Stable Cell Line-CHO
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Cat.#:CSC-P0335Tag:
Source (Host):Species:
Product nameAnti-Human CD18 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0336Tag:
Source (Host):Species:
Product nameAnti-Human CD18 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0337Tag:
Source (Host):Species:
Product nameAnti-Human CD18 scFv Stable Cell Line-CHO
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Involved Pathway

ITGB2 involved in several pathways and played different roles in them. We selected most pathways ITGB2 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
MAP2K6; Itgam&Itgb2; ITGB2; PIK3R3; CALML5; PGF; FGF22; RAPGEF6; PIK3R1; RALGDS
Phagosome
RAB7A; ATP6V1BA; TUBA3B; MHC1UEA; TUBA7L; H2-AA; ATP6V1E1; FCGR3; FCGR2A; ATP6V0D1
Hippo signaling pathway
YWHAG; PPP2R2B; PPP1CB; YAP1; YWHAE; WNT16; TCF7L2; SAV1; TEAD2; FZD3
Cell adhesion molecules (CAMs)
GLG1; CD274; MHC1UEA; CLDNB; ITGA8; CD6; HLA-F; HLA-DRB4; CDH2; CLDN23
Natural killer cell mediated cytotoxicity
SHC4; BID; ULBP1; PIK3R5; KIR2DS3; Ifna11; FAS; RAF1; MICA; ZAP70
Leukocyte transendothelial migration
GNAI2; MSN; CDC42; ROCK2; Itgam&Itgb2; CLDN22; MAPK11; CYBA; CLDN7; PXN
Regulation of actin cytoskeleton
PAK2; DIAP1; MYL12.1; VCLA; ABI2; MYL2B; PIP5K1C; FGF19; ITGB8; PIP5K1BA
Pertussis
C2; CALM2; MAPK1; MAPK3; Il23a; Il12b; IL6; C1QA; NOS2; SERPING1; TICAM2
Legionellosis
EEF1A2; PYCARD; NLRC4; CLK1; ITGB2L; HBS1L; MYD88; HSF1; SEC22B; NAIP7
Leishmaniasis
IRAK4; NCF4; TLR4; HLA-DMB; RELA; HLA-DRB5; STAT1; IFNG; IL1A; FCGR3B
Malaria
SDC2; IL18; KLRK1; HBA1; IFNG; IL1B; MET; SDC1; THBS1; DARC
Amoebiasis
LAMC1; IL12A; CD14; TGFB2; PIK3CA; PRKCA; IL1B; GNA14; RAB7A; C8B
Staphylococcus aureus infection
ICAM1; GM5077; DSG1C; HLA-DQA1; H2-AA; HLA-DRB5; C1QB; FCGR1A; C5AR1; HLA-DRB4
Tuberculosis
ITGAM; CYCS; IRAK2; FCGR1A; NFKB1; HLA-DQA2; MRC2; MAPK13; TGFB3; TNF
HTLV-I infection
ANAPC5; PPP3R1; NFATC4; PDGFB; CD3G; AKT2; TBPL2; TP53INP1; PRKACA; SMAD4
Rheumatoid arthritis
H2-AA; GM-CSF; CD28; IL11; LTB; FOS; HLA-DRB1; IL15; CCL5; IL1A
Viral myocarditis
HLA-G; PRF1; CD86; HLA-F; CASP9; H2-AB1; CAV1; CASP8; SGCD; HLA-C

Protein Function

ITGB2 has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB2 itself. We selected most functions ITGB2 had, and list some proteins which have the same functions with ITGB2. You can find most of the proteins on our site.
Function
Related Protein
Function ICAM-3 receptor activity
Related Protein ITGAL; ITGB2; CLEC4M
Function cell adhesion molecule binding
Related Protein FGFR1; CADM4; CD1D; ITGAL; CADM1B; ITGB3; DSG2; NLGN3; EZR; SELL
Function glycoprotein binding
Related Protein SHB; LMAN2; Serpina1c; LGALS1; Shh; FGFR1; TGFB1; B2M; SERPINA1E; PTBP3
Function metal ion binding
Related Protein Trf; POMT2; RASSF5; MCM2; MAP3K3; ZFP82; GMPR2; CYP1D1; ZDHHC21; OTUD7A
Function protein binding
Related Protein TTC9C; MAFB; WAC; CCNE2; GRIK5; KRIT1; SDC4; CEACAM21; TBX24; CNO
Function protein kinase binding
Related Protein PPP1R12C; TP73; BAG5; ZBTB4; ZC3HC1; CYLD; RAD9; USP37; CCNK; SHC1

Interacting Protein

ITGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB2.
RANBP9; TLN2; NOTCH2NL; RDX; COPS3; ABL1

ITGB2 Related Articles

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).