itgb2
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  • Official Full Name
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • Background
  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
  • Synonyms
  • 95 subunit beta; Beta 2 (antigen CD18 (p95); CD 18; CD18; CD18 antigen; Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor); Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150; Complement component 3 receptor 3 and 4 subunit; Complement receptor C3 beta subunit; Complement receptor C3 subunit beta; Integrin beta 2; Integrin beta chain beta 2; Integrin beta-2; Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2_HUMAN; ITGB 2; ITGB2; LAD; LCAMB; Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; LFA 1; LFA1; Lymphocyte function associated antigen 1; MAC 1; MAC1; Macrophage antigen 1 (mac1) beta subunit; MF17; MFI7; LFA-1; MAC-1
Cat.#:ITGAL & ITGB2-7130HTag:His|Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGB2-4978HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB2 Protein, GST-tagged
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Cat.#:ITGAM&ITGB2-692HTag:N/A
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGAM&ITGB2
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Cat.#:ITGB2-181HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB2 protein, T7/His-tagged
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Cat.#:ITGB2-26324THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-26325THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-71HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ITGB2 protein, His-tagged
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Cat.#:Itgam&Itgb2-605MTag:N/A
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Itgam&Itgb2
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Cat.#:Itgb2-7145MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgb2 protein, His & T7-tagged
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Cat.#:Itgb2-7146RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itgb2 protein, His & T7-tagged
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Cat.#:ITGB2-6803CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGB2
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Cat.#:ITGAX & ITGB2-1875HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAX & ITGB2 cell lysate
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Cat.#:ITGB2-5125HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ITGB2 293 Cell Lysate
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Involved Pathway

ITGB2 involved in several pathways and played different roles in them. We selected most pathways ITGB2 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
PRKCG; GNAI2; VEGFA; RALB; FGF18; IGF1; AKT1; FGFR4; FGFR1; MAP2K6
Phagosome
TUBA2; RAC1A; ATPV0E2; ATP6V1C2; FAM49BA; PIK3C3; RAB5AB; CD209; SFTPD; CALR
Hippo signaling pathway
AJUBA; DVL3; PPP1CB; WNT8A; SMAD4; ITGB2; WWTR1; PPP2CB; GDF5; TEAD1
Cell adhesion molecules (CAMs)
ICOS; HLA-DRB3; SDC4; BF2; CD40LG; ITGB8; CLDN23; NLGN2A; NLGN3A; CD99
Natural killer cell mediated cytotoxicity
PIK3R5; PRKCB; HCST; RAET1L; PPP3R1; TYROBP; IFNA1; FAS; NCR2; KLRC1
Leukocyte transendothelial migration
F11R; VCAM1; EZR; MMP2; ACTG1; PLCG1; CLDN23; BCAR1; CLDN8; VAV3
Regulation of actin cytoskeleton
MLCK2; RASSF7; PIK3R3A; ITGA4; ARHGEF6; RAC1B; FGF21; HRASB; ITGA10; IQGAP2
Pertussis
C4BPA; ITGB1; NLRP3; CXCL5; MAPK12; CASP1; ITGAM; MAPK13; AMCF-II; C1RA
Legionellosis
CD14; Casp3; HSPA1B; Itgam&Itgb2; RAB1B; CASP8; RELA; ITGB2L; HSPA1A; HSPA8
Leishmaniasis
IL1A; IL12A; IL4; FCGR1A; HLA-DMA; NCF2; RELA; HLA-DQA1; HLA-DMB; NOS2
Malaria
CCL2; MYD88; HGF; TNF; MET; HBA1; TGFB1; COMP; GYPC; SDC1
Amoebiasis
RAB7; LAMC3; COL3A1; C8A; Casp3; RAB5C; PIK3R1; LAMB4; LAMB1; COL4A6
Staphylococcus aureus infection
FCAR; ITGAL; C5AR1; HLA-DQA1; C3AR1; MASP1; C1QB; CFI; ITGAM; FPR2
Tuberculosis
MYD88; IFNA16; BAD; CD209B; LBP; IFNA5; NFYA; IFNA10; BAX; CAMK2G
HTLV-I infection
CCND3; BUB3; ATF4; PPP3R2; HLA-DMA; STAT5B; NFKB1; HLA-DQA2; CD3E; CD3D; NFATC1
Rheumatoid arthritis
ATP6V0C; ATP6V0B; ITGAL; ITGB2; Ccl12; TLR4; ATP6V0E1; IL6; Ctsl; ATP6AP1
Viral myocarditis
H2-Q10; HLA-DOB; ITGB2L; HLA-B; CD40LG; EIF4G2; BID; RAC1; MYH7; ICAM1

Protein Function

ITGB2 has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB2 itself. We selected most functions ITGB2 had, and list some proteins which have the same functions with ITGB2. You can find most of the proteins on our site.
Function
Related Protein
Function ICAM-3 receptor activity
Related Protein ITGB2; CLEC4M; ITGAL
Function cell adhesion molecule binding
Related Protein PVRL1; PVRL3; GRIN2A; ITGA4; NLGN2; DSG2; GLYCAM1; JUP; AMICA1; PTPRD
Function glycoprotein binding
Related Protein SERPINA1; FBXO27; VIM; RGMA; BBC3; OS9; LACRT; Shh; ITGAM; AZGP1
Function metal ion binding
Related Protein ELP3; CYP2C39; HARBI1; GALNT6; ZNF70; ATF7B; DMRTB1; ZBTB25; OSGEP; ZFP36
Function protein binding
Related Protein TUBGCP2; FUCA2; PIK3CG; EDARADD; IGFBP7; HBB; OAZ1; NDUFA4; TLE4; DYRK1B
Function protein kinase binding
Related Protein PPP1CC; GRIN2A; PDPK1; PXN; RNF138; IL12RB2; PARN; PPP1R15A; HDAC7; BCL10

Interacting Protein

ITGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB2.
RANBP9; TLN2; NOTCH2NL; RDX; COPS3; ABL1

ITGB2 Related Articles

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).