itgb2
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  • Official Full Name
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • Background
  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
  • Synonyms
  • 95 subunit beta; Beta 2 (antigen CD18 (p95); CD 18; CD18; CD18 antigen; Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor); Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150; Complement component 3 receptor 3 and 4 subunit; Complement receptor C3 beta subunit; Complement receptor C3 subunit beta; Integrin beta 2; Integrin beta chain beta 2; Integrin beta-2; Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2_HUMAN; ITGB 2; ITGB2; LAD; LCAMB; Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; LFA 1; LFA1; Lymphocyte function associated antigen 1; MAC 1; MAC1; Macrophage antigen 1 (mac1) beta subunit; MF17; MFI7; LFA-1; MAC-1
Cat.#:ITGAL & ITGB2-7130HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGB2-4978HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB2 Protein, GST-tagged
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Cat.#:ITGAM&ITGB2-692HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGAM&ITGB2
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Cat.#:ITGB2-181HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB2 protein, T7/His-tagged
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Cat.#:ITGB2-26324THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-26325THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGB2
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Cat.#:ITGB2-71HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ITGB2 protein, His-tagged
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Cat.#:Itgam&Itgb2-605MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Itgam&Itgb2
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Cat.#:Itgb2-7145MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgb2 protein, His & T7-tagged
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Cat.#:Itgb2-7146RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itgb2 protein, His & T7-tagged
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Cat.#:ITGB2-6803CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGB2
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Cat.#:ITGAX & ITGB2-1875HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAX & ITGB2 cell lysate
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Cat.#:ITGB2-5125HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGB2 293 Cell Lysate
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Cat.#:CSC-P0026Tag:
Source (Host):Species:
Product nameAnti-Human ITGB2 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0027Tag:
Source (Host):Species:
Product nameAnti-Human ITGB2 scFv Stable Cell Line-CHO
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Cat.#:CSC-P0335Tag:
Source (Host):Species:
Product nameAnti-Human CD18 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0336Tag:
Source (Host):Species:
Product nameAnti-Human CD18 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0337Tag:
Source (Host):Species:
Product nameAnti-Human CD18 scFv Stable Cell Line-CHO
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Involved Pathway

ITGB2 involved in several pathways and played different roles in them. We selected most pathways ITGB2 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
FGF22; FGF3; PARD3; RAPGEF6; PIK3R1; FGF10; ANGPT4; PIK3CB; GNAI2; MAPK13
Phagosome
HLA-DMB; ATP6V0D1; CORO1A; Pla2r1; ATP6V1B2; CD209B; ATP6V0B; NOX3; RAB5AB; CD209C
Hippo signaling pathway
BMPR2; LATS1; GLI2; FZD1; CCND3; TEAD3; AREG; FRMD6; PPP1CB; PPP1CA
Cell adhesion molecules (CAMs)
SELP; CLDN6; GLG1; NRXN1; HLA-DRB3; LRRC4B; F11R; CD4; ICOSLG; NCAM1A
Natural killer cell mediated cytotoxicity
ITGB2L; KLRA8; ICAM2; FAS; KLRD1; NFATC1; PRKCA; SH2D1A; HLA-G; GZMB
Leukocyte transendothelial migration
NCF4; PIK3CA; MAPK11; PXN; ITGB2L; CLDN3; CD99; CLDN1; MAPK12; PRKCA
Regulation of actin cytoskeleton
RHOAD; INS1; DIAPH3; ITGB1A; ACTN3B; PIP5K1BB; GNA12; ITGA6; MYL7; EZR
Pertussis
SERPING1; IL-8; MAPK13; C4BP; MAPK8; ITGAM; CALM2; Itgam&Itgb2; TRAF6; ITGA5
Legionellosis
IL-8; SEC22B; HSPA1A; CR1; HSPA2; BNIP3; PYCARD; HBS1L; CYCS; TLR5
Leishmaniasis
PTGS2; MARCKSL1; NOS2; IRAK4; FCGR2C; FCGR3; IL1A; FCGR3A; TGFB3; IRAK1
Malaria
CSF3; GYPB; CD40; IL12A; KLRC4-KLRK1; Ccl12; CD81; TLR4; SDC1; HBB-B1
Amoebiasis
COL1A2; GNAQ; PRKCA; C8G; PIK3R5; ITGB2L; TGFB1; PIK3CD; PIK3CA; IL12A
Staphylococcus aureus infection
HLA-DQA1; HLA-DQA2; C2; FCGR4; MBL2; HLA-DRB4; HLA-DRB3; HLA-DPA1; FCGR3B; MASP1
Tuberculosis
CD209A; ATP6AP1; ITGB2; NFYB; HLA-DRB4; CAMP; IFNA6; PPP3CC; CALM3; CALM1
HTLV-I infection
HLA-G; FZD7; DLG1; PRKACG; FZD2; MSX1; TGFB3; SRF; WNT9A; GM-CSF
Rheumatoid arthritis
IL11; HLA-DPB1; TGFB3; CD80; ATP6V1H; HLA-DQA1; Ctsl; ATP6V1E1; ATP6V1G1; ITGAL
Viral myocarditis
ACTG1; SGCG; CASP9; CXADR; MYH7; HLA-DRB5; HLA-DMA; CAV1; HLA-DQA1; SGCA

Protein Function

ITGB2 has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB2 itself. We selected most functions ITGB2 had, and list some proteins which have the same functions with ITGB2. You can find most of the proteins on our site.
Function
Related Protein
Function ICAM-3 receptor activity
Related Protein CLEC4M; ITGAL; ITGB2
Function cell adhesion molecule binding
Related Protein GLYCAM1; DSG2; POSTN; CXADR; CD1D; CADM1; MSN; LPHN1; PVRL3B; ITGAL
Function glycoprotein binding
Related Protein LRRK2; ITGB2; PIP; ITGAM; CNTN1; FLNA; SHB; ERBB2; RGMA; TGFB1
Function metal ion binding
Related Protein SALL1A; ZFP106; ADAMTS12; ZNF19; FTH1B; NOS2A; FUZ; FYN; ME3; GALNTL1
Function protein binding
Related Protein TCEANC2; MOCOS; UBE2V2; SOX13; ITGB3; MRPS9; SH3BP4; SETD2; ELF3; TRIM13
Function protein kinase binding
Related Protein ZBTB4; SREBF1; CCNL1A; SPRED2; CCNB3; NGFRAP1; IRS2; PTPN1; CASP9; APC

Interacting Protein

ITGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB2.
RANBP9; TLN2; NOTCH2NL; RDX; COPS3; ABL1

ITGB2 Related Articles

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).