il4ra
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  • Official Full Name
  • interleukin 4 receptor, alpha
  • Background
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind;interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to;promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the;membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by;T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as;allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to;human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • interleukin 5 (colony-stimulating factor, eosinophil); IL5; IL-5; interleukin 5; TRF; T-cell replacing factor; interleukin-5; eosinophil differentiation factor
Cat.#:IL4RA-351MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL4RA Protein, Fc-tagged
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Cat.#:Il4ra-1758MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il4ra Protein, His-tagged
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Cat.#:Il4ra-2130MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il4ra protein, His & T7-tagged
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Cat.#:Il4ra-5662MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged
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Cat.#:IL4RA-8174MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL4RA Protein
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Cat.#:IL4RA-3048RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL4RA Protein
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Cat.#:Il4ra-7458RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il4ra, His tagged
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Cat.#:Il4ra-1757MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged
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Involved Pathway

Il4ra involved in several pathways and played different roles in them. We selected most pathways Il4ra participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il4ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
FLT4; CCL15; CD40; CXCL2; CCL5; IL15RA; GH1; CSF1; CSH; CXCL8B.3
PIK-Akt signaling pathway
PTK2; GNB3; LAMA2; TCL1; KITLG; GNB2; PPP2R1A; Kitl; MAP2K2; STK11
Jak-STAT signaling pathway
AOX3; JAK2B; CSH1; IFNL3; STAM; IL5RA; IL2RGA; SOCS1; CRFB2; SOCS5
Hematopoietic cell lineage
CD19; CD38; CD5; CD1B; CD24; MME; CR1; CD59; CSF1; IL11
Inflammatory bowel disease (IBD)
TGFB3; IFNG; GATA3; HLA-DPA1; IL4R; TLR2; IL1B; HLA-DRB3; IL18R1; HLA-DQA1

Protein Function

Il4ra has several biochemical functions, for example, cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il4ra itself. We selected most functions Il4ra had, and list some proteins which have the same functions with Il4ra. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein IL20RA; LIFRA; LEPR; GHRA; IL2RGA; IL11RA; CRFB6; IL4R.1; IL31RA; IL12RB1
Function protein binding
Related Protein CDT1; CYB5R2; TSNAX; TDGF1; Raet1a; DPM1; FBF1; NME4; TNFAIP1; ARHGEF1

Il4ra Related Gene Family

IL