lmnb2
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  • Official Full Name
  • LMNB2 lamin B2
  • Background
  • An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. Atype lamins and Btype lamins. The Atype lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the Btype lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of ahelices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organised into loops, which are attached to the nuclear matrix. This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A and Btype lamins.
  • Synonyms
  • LMNB2; lamin B2; LMN2; lamin-B2; LAMB2; MGC2721;
Cat.#:LMNB2-737HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LMNB2 Protein, MYC/DDK-tagged
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Cat.#:LMNB2-9155MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LMNB2 Protein
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Cat.#:LMNB2-6837CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LMNB2
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Cat.#:LMNB2-8634ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LMNB2
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Involved Pathway

LMNB2 involved in several pathways and played different roles in them. We selected most pathways LMNB2 participated on our site, such as FAS pathway and Stress induction of HSP regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMNB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FAS pathway and Stress induction of HSP regulation
DFFA; LMNB2; FAF1; DAXX

Protein Function

LMNB2 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LMNB2 itself. We selected most functions LMNB2 had, and list some proteins which have the same functions with LMNB2. You can find most of the proteins on our site.
Function
Related Protein
Function structural molecule activity
Related Protein EPB41L1; COPE; CLDN10A; INAB; LAD1; CLDN7; EPB41L3A; CLDN23; EPB41L3B; SNTA1

Interacting Protein

LMNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMNB2.
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LMNB2 Related Articles

Lee, JY; Jee, SB; et al. Tumor Suppressor Protein p53 Promotes 2-Methoxyestradiol-Induced Activation of Bak and Bax, Leading to Mitochondria-Dependent Apoptosis in Human Colon Cancer HCT116 Cells. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 24:1654-1663(2014).
Tsai, YJ; Lee, HI; et al. Ribosome Distribution in HeLa Cells during the Cell Cycle. PLOS ONE 7:-(2012).