| Description : |
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
67.7 kDa |
| AA Sequence : |
MATPLPGRAGGPATPLSPTRLSRLQ EKEELRELNDRLAHYIDRVRALELE NDRLLLKISEKEEVTTREVSGIKAL YESELADARRVLDETARERARLQIE IGKLRAELDEVNKSAKKREGELTVA QGRVKDLESLFHRSEVELAAALSDK RGLESDVAELRAQLAKAEDGHAVAK KQLEKETLMRVDLENRCQSLQEELD FRKSVFEEEVRETRRRHERRLVEVD SSRQQEYDFKMAQALEELRSQHDEQ VRLYKLELEQTYQAKLDSAKLSSDQ NDKAASAAREELKEARMRLESLSYQ LSGLQKQASAAEDRIRELEEAMAGE RDKFRKMLDAKEQEMTEMRDVMQQQ LAEYQELLDVKLALDMEINAYRKLL EGEEERLKLSPSPSSRVTVSRATSS SSGSLSATGRLGRSKRKRLEVEEPL GSGPSVLGTGTGGSGGFHLAQQASA SGSVSIEEIDLEGKFVQLKNNSDKD QSLGNWRIKRQVLEGEEIAYKFTPK YILRAGQMVTVWAAGAGVAHSPPST LVWKGQSSWGTGESFRTVLVNADGE EVAMRTVKKSSVMRENENGEEEEEE AEFGEEDLFHQQGDPRTTSRGCYVM TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
