loxl2
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  • Official Full Name
  • lysyl oxidase-like 2
  • Background
  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family.
  • Synonyms
  • LOXL2; lysyl oxidase-like 2; lysyl oxidase homolog 2; WS9 14; LOR 2; LOR2; LOX L2; LOXL 2; LOXL2_HUMAN; Lysyl oxidase like 2; Lysyl oxidase like protein 2; Lysyl oxidase related 2; Lysyl oxidase related protein 2; Lysyl oxidase related protein WS9 14; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; OTTHUMP00000224942; WS9-14
Cat.#:LOXL2-1447MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse LOXL2 Protein (26-776 aa), His-tagged
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Cat.#:LOXL2-630MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse LOXL2 Protein (26-776 aa), His-tagged
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Cat.#:LOXL2-272HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LOXL2 Protein, His-tagged
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Cat.#:LOXL2-4731HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LOXL2 Protein, GST-tagged
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Cat.#:Loxl2-274MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Loxl2 Protein, His-tagged
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Cat.#:Loxl2-275RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Loxl2 Protein, His-tagged
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Cat.#:LOXL2-150HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LOXL2, GST-tagged
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Cat.#:LOXL2-288HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human LOXL2, His-tagged
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Cat.#:LOXL2-29651THTag:FLAG
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LOXL2 protein, FLAG-tagged
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Cat.#:LOXL2-329HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human LOXL2 Protein, His-tagged
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Cat.#:LOXL2-330HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human LOXL2 Protein, Fc-tagged
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Cat.#:LOXL2-3920HTag:Avi/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LOXL2 Protein, Avi/His-tagged
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Cat.#:LOXL2-3923HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LOXL2, His tagged
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Cat.#:Loxl2-262MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Loxl2 protein, His-tagged
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Cat.#:LOXL2-9186MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Loxl2 protein, His-tagged
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Cat.#:LOXL2-3433RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LOXL2 Protein
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Cat.#:LOXL2-1854HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LOXL2 cell lysate
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Involved Pathway

LOXL2 involved in several pathways and played different roles in them. We selected most pathways LOXL2 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
LOXL1; DST; COL5A3A; COL8A2; CTSL2; TLL1; COL10A1A; LOXL3; COL4A5; BMP1B
Collagen formation
COL16A1; COL9A1B; PPIB; EMID2; SERPINH1; PRP; COL9A1; PCOLCEB; COL9A1A; COL3A1
Crosslinking of collagen fibrils
LOXL1; LOX; LOXL2; BMP1A; LOXL3; ABHD1; BMP1B; LOXL4; PCOLCE; TLL2
Elastic fibre formation
MFAP1B; ABHD1; LOXL2; MFAP2; FURINB; LOXL1; EFEMP1; LOXL3; FBLN1; MFAP3
Extracellular matrix organization
FAM49BA; CEACAM1; LOXL4; FBN1; FN1B; LAMB1B; P3H2; PRP; FBLN2; MMP19

Protein Function

LOXL2 has several biochemical functions, for example, chromatin binding, copper ion binding, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL2 itself. We selected most functions LOXL2 had, and list some proteins which have the same functions with LOXL2. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein TP73; PAF1; KDM1A; AJUBA; SFPQ; ORC1L; DNMT3A; CRTC2; MLH3; MEN1
Function copper ion binding
Related Protein APOA4; POLR1B; RNF7; GPC1; SNCA; METTL17; AOC3; HAMP; LOX; MT1
Function electron carrier activity
Related Protein IVD; PTGESL; AOC2; CYBA; TSTA3; CYCSB; ACAD9; AKR7A3; COX7A1; ASPH
Function methylated histone binding
Related Protein DPPA3; CBX7; ING2; PHF19; FAM156A; RBBP5; MTF2; MPHOSPH8; ING4; ING3
Function oligosaccharide binding
Related Protein LOXL2; CHID1; DCBLD1; RS1A; SELE; SELP
Function protein binding
Related Protein RCC2; ABCE1; FIBCD1; TMEM8B; GLS2; HSD17B12; MSLN; TAG-260; NSL1; FAM162A
Function protein-lysine 6-oxidase activity
Related Protein LOXL2B; ABHD1; LOXL2A; LOX; POLR1B; LOXL3; LOXL4; LOXL2
Function scavenger receptor activity
Related Protein SUSD2; ENDOU; CD5L; SCARA5; TINAG; TMPRSS15; TMPRSS4A; SCARF2; LOXL2; ENPP2
Function transcription corepressor activity
Related Protein NAB2; ARHGAP35; WNT4; NSD1; RARA; ATN1; HOXC6; CREG1; TLE4; ID4

Interacting Protein

LOXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL2.
MARCKSL1; PDIA3; EGFL7

LOXL2 Related Articles

Meissner, EG; McLaughlin, M; et al. Longitudinal hepatic and PBMC gene expression profiling of HIV and/or HCV-infected patients with advanced liver disease treated with simtuzumab, an anti-LOXL2 antibody. HEPATOLOGY 60:421A-421A(2014).
Barker, HE; Bird, D; et al. Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling. MOLECULAR CANCER RESEARCH 11:1425-1436(2013).