LOXL2
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Official Full Name
lysyl oxidase-like 2
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Overview
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family. -
Synonyms
LOXL2; lysyl oxidase-like 2; lysyl oxidase homolog 2; WS9 14; LOR 2; LOR2; LOX L2; LOXL 2; LOXL2_HUMAN; Lysyl oxidase like 2; Lysyl oxidase like protein 2; Lysyl oxidase related 2; Lysyl oxidase related protein 2; Lysyl oxidase related protein WS9 14; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; OTTHUMP00000224942; WS9-14;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- Avi|His
- C
- Avi
- His
- Fc
- FLAG
- GST
- His (Fc)
- human|IgG1|Fc
- N/A
- N
- 8His
- Involved Pathway
- Protein Function
- Interacting Protein
- LOXL2 Related Articles
- LOXL2 Related Research Area
LOXL2 involved in several pathways and played different roles in them. We selected most pathways LOXL2 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of collagen fibrils and other multimeric structures | COL10A1;CTSS;BMP1B;COL3A1;CTSB;ABHD1;COL2A1;LOX;COL8A1A |
| Collagen formation | COL2A1;CTSL1;COL8A2;COL1A2;PCOLCEB;PCOLCE2B;ABHD1;LOX;EMID2 |
| Crosslinking of collagen fibrils | BMP1B;TLL2;PCOLCE;LOX;LOXL3;BMP1;TLL1;ABHD1;LOXL1 |
| Elastic fibre formation | FBLN1;LOXL3;EFEMP1;ITGB3A;FBLN2;FURINA;BMP10;MFAP1;LOXL4 |
| Extracellular matrix organization | BGNA;ABHD1;TLL1;COL10A1A;COL17A1;EFEMP2;CRTAP;COL5A2;CMA1 |
LOXL2 has several biochemical functions, for example, chromatin binding, copper ion binding, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL2 itself. We selected most functions LOXL2 had, and list some proteins which have the same functions with LOXL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ATF2;SSRP1A;CITED1;SMAD4;RNF168;ELK1;MCM5;ZFP354B;TICRR |
| copper ion binding | HIST2H3A;SERPINB1A;IL1A;RNF7;SLC11A2;PRNP;LOXL5B;PRND;ATP7A |
| electron carrier activity | PTGESL;NCF1;AKR1C4;XDH;NDUFA12;SDHC;ACADSB;ACOX2;DERL3 |
| methylated histone binding | CBX7;GLYR1;LRWD1;PHF19;ING3;KAT8;ZMYND11;CBX8;WDR92 |
| oligosaccharide binding | DCBLD1;SELE;SELP;LOXL2;CHID1;RS1A |
| protein binding | INTS10;KCNQ4;GSDMD;FXN;RBBP4;ATP6V1H;RWDD1;CSN3;BEX2 |
| protein-lysine 6-oxidase activity | LOX;LOXL2;ABHD1;POLR1B;LOXL2A;LOXL4;LOXL3;LOXL2B |
| scavenger receptor activity | SUSD2;TMPRSS4;CCBP2;SCARA5;CXCR7;LOXL4;LOXL2A;HHIPL1;TMPRSS4B |
| transcription corepressor activity | C1D;JUNB;SKOR1;RCOR2;SKOR1A;ZEB1;ASXL1;FOXP3;ATN1 |
LOXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL2.
MARCKSL1; PDIA3; EGFL7
- Q&As
- Reviews
Q&As (5)
Ask a questionLOXL2 promotes the cross-linking of elastin fibers, affecting tissue elasticity. Understanding these mechanisms can have implications in diseases where tissue flexibility is crucial, such as in cardiovascular conditions.
LOXL2 is involved in tissue repair and wound healing by modulating the extracellular matrix. Targeting LOXL2 may offer therapeutic opportunities to enhance or control the wound healing process.
Elevated levels of LOXL2 have been associated with certain diseases. Measuring LOXL2 levels can potentially serve as a diagnostic marker for conditions such as liver fibrosis and certain cancers.
Yes, several clinical trials are exploring the potential of LOXL2 inhibitors in treating fibrosis and cancer. These trials aim to validate the efficacy and safety of targeting LOXL2 in clinical settings.
LOXL2 is implicated in fibrosis as it plays a key role in collagen cross-linking, influencing tissue stiffness and architecture, making it a potential target for anti-fibrotic therapies.
Customer Reviews (3)
Write a reviewThis protein exhibits outstanding performance in ELISA, providing accurate and reliable results in detecting and quantifying specific antigens.
Its high sensitivity ensures the detection of even low abundance targets, making it a valuable tool in immunoassays.
Its stability and compatibility with electron microscopy techniques make it an excellent choice for studying protein structures at high resolution.
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