Recombinant Human LOXL2 Protein (Gln26-Gln774), C-Avi-His tagged

• Cat.No.: LOXL2-4452H
• Product Overview: Recombinant human LOXL2 (Gln26-Gln774) fused with the C-terminal Avi-His tag was expressed in Mammalian cells.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: His&Avi
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 82.39 kDa
• Protein length: Gln26-Gln774
• Endotoxin: < 1.0 EU/μg of the protein as determined by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS or lyophilized from PBS.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: LOXL2 lysyl oxidase-like 2 [ Homo sapiens (human) ]
• Official Symbol: LOXL2
• Synonyms: LOXL2; lysyl oxidase-like 2; lysyl oxidase homolog 2; WS9 14; lysyl oxidase related 2; lysyl oxidase-like protein 2; lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; LOR2; WS9-14
• Gene ID: 4017
• mRNA Refseq: NM_002318
• Protein Refseq: NP_002309
• MIM: 606663
• UniProt ID: Q9Y4K0

Reviews

06/20/2022

This protein exhibits outstanding performance in ELISA, providing accurate and reliable results in detecting and quantifying specific antigens.

01/16/2022

Its high sensitivity ensures the detection of even low abundance targets, making it a valuable tool in immunoassays.

03/23/2016

Its stability and compatibility with electron microscopy techniques make it an excellent choice for studying protein structures at high resolution.

Q&As

In what ways does LOXL2 impact tissue elasticity, and how is this relevant in clinical applications?

LOXL2 promotes the cross-linking of elastin fibers, affecting tissue elasticity. Understanding these mechanisms can have implications in diseases where tissue flexibility is crucial, such as in cardiovascular conditions.

How does LOXL2 influence wound healing, and can it be targeted for therapeutic interventions?

LOXL2 is involved in tissue repair and wound healing by modulating the extracellular matrix. Targeting LOXL2 may offer therapeutic opportunities to enhance or control the wound healing process.

Are there diagnostic applications of LOXL2 in clinical settings?

Elevated levels of LOXL2 have been associated with certain diseases. Measuring LOXL2 levels can potentially serve as a diagnostic marker for conditions such as liver fibrosis and certain cancers.

Are there ongoing clinical trials targeting LOXL2 for therapeutic purposes?

Yes, several clinical trials are exploring the potential of LOXL2 inhibitors in treating fibrosis and cancer. These trials aim to validate the efficacy and safety of targeting LOXL2 in clinical settings.

How does LOXL2 contribute to the clinical understanding of fibrosis?

LOXL2 is implicated in fibrosis as it plays a key role in collagen cross-linking, influencing tissue stiffness and architecture, making it a potential target for anti-fibrotic therapies.