Description : |
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Fc |
Form : |
Lyophilized |
Molecular Mass : |
111.6 kDa |
Protein Length : |
774 |
AA Sequence : |
MERPLCSHLCSCLAMLALLSPLSLA QYDSWPHYPEYFQQPAPEYHQPQAP ANVAKIQLRLAGQKRKHSEGRVEVY YDGQWGTVCDDDFSIHAAHVVCREL GYVEAKSWTASSSYGKGEGPIWLDN LHCTGNEATLAACTSNGWGVTDCKH TEDVGVVCSDKRIPGFKFDNSLINQ IENLNIQVEDIRIRAILSTYRKRTP VMEGYVEVKEGKTWKQICDKHWTAK NSRVVCGMFGFPGERTYNTKVYKMF ASRRKQRYWPFSMDCTGTEAHISSC KLGPQVSLDPMKNVTCENGLPAVVS CVPGQVFSPDGPSRFRKAYKPEQPL VRLRGGAYIGEGRVEVLKNGEWGTV CDDKWDLVSASVVCRELGFGSAKEA VTGSRLGQGIGPIHLNEIQCTGNEK SIIDCKFNAESQGCNHEEDAGVRCN TPAMGLQKKLRLNGGRNPYEGRVEV LVERNGSLVWGMVCGQNWGIVEAMV VCRQLGLGFASNAFQETWYWHGDVN SNKVVMSGVKCSGTELSLAHCRHDG EDVACPQGGVQYGAGVACSETAPDL VLNAEMVQQTTYLEDRPMFMLQCAM EENCLSASAAQTDPTTGYRRLLRFS SQIHNNGQSDFRPKNGRHAWIWHDC HRHYHSMEVFTHYDLLNLNGTKVAE GHKASFCLEDTECEGDIQKNYECAN FGDQGITMGCWDMYRHDIDCQWVDI TDVPPGDYLFQVVINPNFEVAESDY SNNIMKCRSRYDGHRIWMYNCHIGG SFSEETEKKFEHFSGLLNNQLSPQ |
Purity : |
> 98% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
At -20 centigrade. |
Concentration : |
1 mg/mL |
Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |