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LRP6

  • Official Full Name

    low density lipoprotein receptor-related protein 6

  • Overview

    LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain,
  • Synonyms

    LRP6; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; ADCAD2; FLJ90062; FLJ90421;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Fc
  • Flag
  • His
  • His (Fc)
  • Avi
  • Mouse|IgG|Fc
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRP6-1040H Active Recombinant Human LRP6 Protein, Fc Chimera Mammalian cells Fc
Human LRP6-7875H Recombinant Human LRP6 protein, His-tagged E.coli His Trp981~Gly1213
Human LRP6-4654HCL Recombinant Human LRP6 293 Cell Lysate HEK293 N/A
Human LRP6-01H Recombinant Human LRP6 Protein, MYC/DDK-tagged HEK293T C-Myc/DDK
Human LRP6-552H Recombinant Human LRP6 protein, Mouse IgG Fc-tagged HEK293 Mouse/IgG/Fc Ala20-Pro630
Human LRP6-731HFL Recombinant Full Length Human LRP6 Protein, C-Flag-tagged Mammalian cells Flag
Human LRP6-7875HB Recombinant Human LRP6 Protein, N-His tagged, Avi-biotinylated E.coli N-His
Human LRP6-122H Recombinant Human LRP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LRP6-0371H Active Recombinant Human LRP6 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala20-Pro630
Human LRP6-122H-B Recombinant Human LRP6 Protein Pre-coupled Magnetic Beads HEK293
Human LRP6-4457H Recombinant Human LRP6 Protein (Ala20-Pro1368), N-His tagged E.coli N-His Ala20-Pro1368
Mouse Lrp6-1051M Active Recombinant Mouse Lrp6 Protein, His-tagged Mammalian cells His Ala20-Pro1368
Mouse LRP6-9239M Recombinant Mouse LRP6 Protein Mammalian Cell His
Mouse Lrp6-5166M Recombinant Mouse Lrp6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lrp6-1338M Recombinant Mouse Lrp6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Lrp6-5166M-B Recombinant Mouse Lrp6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LRP6-2552R Recombinant Rhesus monkey LRP6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LRP6-2372R Recombinant Rhesus Macaque LRP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LRP6-2372R-B Recombinant Rhesus Macaque LRP6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LRP6-7173Z Recombinant Zebrafish LRP6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LRP6 Related Articles
  • LRP6 Related Research Area
  • LRP6 Related Signal Pathway

LRP6 involved in several pathways and played different roles in them. We selected most pathways LRP6 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayFZD3;PRKACAB;PRKACA;FZD9B;FOSL1;SIAH1;DKK1B;VANGL2;ROCK2

LRP6 has several biochemical functions, for example, Wnt-activated receptor activity, Wnt-protein binding, apolipoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP6 itself. We selected most functions LRP6 had, and list some proteins which have the same functions with LRP6. You can find most of the proteins on our site.

Function Related Protein
Wnt-activated receptor activityFZD8;FZD1;FZD10;FZD7B;FZD9;FZD2;LRP6;LRP5L;LRP5
Wnt-protein bindingFZD8B;SFRP2;ROR1;FZD6;SETD6;SFRP1A;APCDD1;PTPRO;FZD8
apolipoprotein bindingCANX;LIPC;PCSK9;LPL;LRP4;SCARB1;VLDLR;ABCA1;LRP1
coreceptor activity involved in Wnt signaling pathway
frizzled bindingWNT2BB;ROR2;CTHRC1;DVL1B;RNF43;RSPO3;MYOC;WNT3;WNT4B
identical protein bindingDNMT3A;GDF5;VPS41;MSANTD3;LCP1;ALDOA;ACTN2;THBS1;GLE1
kinase inhibitor activitySOCS1;RHOH;AHSG;LRP6
low-density lipoprotein receptor activityVLDLR;CXCL16;LDLR;LRP12;LRP6;OLR1
protein bindingGRIA2;EPHB6;C12orf40;KLHL41;FAM92A;TMEM183A;TBC1D22B;RABGAP1;SORBS3
protein homodimerization activityAnks6;PGCP;GRM6;DMRTC1B;TFAP4;USH1G;IZUMO3;SMAD4;PKD2
receptor bindingSMAGP;DHRS4;ACOT8;ANGPT2;TAC3;DAO1;TENC1;DECR2;GCG
toxin transporter activitySLC17A3;SLC7A8;SLC22A3;ABCG1;SLC22A2;LRP6
NOT toxin transporter activityLRP6;LRP5

LRP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP6.

Fzd8; GSK3B; Axin1

Tella, SH; Gallagher, JC; et al. Biological agents in management of osteoporosis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 70:1291-1301(2014).
Qian, LL; Cai, CZ; et al. Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. SCIENCE CHINA-LIFE SCIENCES 57:469-481(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does LRP6 interact with Wnt signaling pathways, and what is its role in modulating Wnt signaling? 02/13/2022

LRP6 interacts with Wnt signaling pathways by forming a complex with Frizzled receptors, initiating Wnt pathway activation.

In which cellular compartments is LRP6 predominantly localized? 01/12/2021

LRP6 is predominantly localized on the cell membrane, where it acts as a co-receptor for Wnt ligands.

Are there specific Wnt ligands or co-receptors that LRP6 interacts with, influencing Wnt pathway activation? 11/18/2019

Specific Wnt ligands or co-receptors that LRP6 interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.

What diseases or conditions are associated with dysregulation or abnormal expression of LRP6? 04/25/2018

Dysregulation or abnormal expression of LRP6 is associated with conditions such as cancer and osteoporosis.

How does LRP6 contribute to the regulation of cell proliferation, differentiation, or tissue development? 05/28/2017

LRP6 contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.

Are there therapeutic implications or potential targets related to LRP6 in diseases involving Wnt signaling? 08/19/2016

There are potential therapeutic implications related to LRP6 in diseases involving Wnt signaling, making it a target for drug development.

What is the primary function of Low-density lipoprotein receptor-related protein 6 (LRP6) in cellular processes and signaling? 03/31/2016

Low-density lipoprotein receptor-related protein 6 (LRP6) functions in cellular processes, primarily playing a role in Wnt signaling.

Customer Reviews (3)

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Reviews
04/07/2021

    We appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.

    09/11/2020

      We appreciated the product's recognition in peer-reviewed journals, further establishing its importance in our field.

      01/17/2018

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

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