| Description : |
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
N-His |
| Form : |
Lyophilized |
| Molecular Mass : |
32.2 kDa |
| AA Sequence : |
MGSSHHHHHHGLNDIFEAQKIEWHE SSGLVPRGSHMASMTGGQQMGRGSE FWIDSRQNMIRKAQEDGSQGFTVVV SSVPSQNLEIQPYDLSIDIYSRYIY WTCEATNVINVTRLDGRSVGVVLKG EQDRPRAVVVNPEKGYMYFTNLQER SPKIERAALDGTEREVLFFSGLSKP IALALDSRLGKLFWADSDLRRIESS DLSGANRIVLEDSNILQPVGLTVFE NWLYWIDKQQQMIEKIDMTGREGRT KVQARIAQLSDIHAVKELNLQEYRQ HPCAQDNGG |
| Endotoxin : |
<1 EU/μg by LAL |
| Purity : |
> 90% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from PBS, pH 7.4, 5% trehalose, 5% mannitol |
