Recombinant Full Length Human LRP6 Protein, C-Flag-tagged

• Cat.No.: LRP6-731HFL
• Product Overview: Recombinant Full Length Human LRP6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 178.4 kDa
• AA Sequence: MGAVLRSLLACSFCVLLRAAPLLLY ANRRDLRLVDATNGKENATIVVGGL EDAAAVDFVFSHGLIYWSDV SEEAIKRTEFNKTESVQNVVVSGLL SPDGLACDWLGEKLYWTDSETNRIE VSNLDGSLRKVLFWQELDQP RAIALDPSSGFMYWTDWGEVPKIER AGMDGSSRFIIINSEIYWPNGLTLD YEEQKLYWADAKLNFIHKSN LDGTNRQAVVKGSLPHPFALTLFED ILYWTDWSTHSILACNKYTGEGLRE IHSDIFSPMDIHAFSQQRQP NATNPCGIDNGGCSHLCLMSPVKPF YQCACPTGVKLLENGKTCKDGATEL LLLARRTDLRRISLDTPDFT DIVLQLEDIRHAIAIDYDPVEGYIY WTDDEVRAIRRSFIDGSGSQFVVTA QIAHPDGIAVDWVARNLYWT DTGTDRIEVTRLNGTMRKILISEDL EEPRAIVLDPMVGYMYWTDWGEIPK IERAALDGSDRVVLVNTSLG WPNGLALDYDEGKIYWGDAKTDKIE VMNTDGTGRRVLVEDKIPHIFGFTL LGDYVYWTDWQRRSIERVHK RSAEREVIIDQLPDLMGLKATNVHR VIGSNPCAEENGGCSHLCLYRPQGL RCACPIGFELISDMKTCIVP EAFLLFSRRADIRRISLETNNNNVA IPLTGVKEASALDFDVTDNRIYWTD ISLKTISRAFMNGSALEHVV EFGLDYPEGMAVDWLGKNLYWADTG TNRIEVSKLDGQHRQVLVWKDLDSP RALALDPAEGFMYWTEWGGK PKIDRAAMDGSERTTLVPNVGRANG LTIDYAKRRLYWTDLDTNLIESSNM LGLNREVIADDLPHPFGLTQ YQDYIYWTDWSRRSIERANKTSGQN RTIIQGHLDYVMDILVFHSSRQSGW NECASSNGHCSHLCLAVPVG GFVCGCPAHYSLNADNRTCSAPTTF LLFSQKSAINRMVIDEQQSPDIILP IHSLRNVRAIDYDPLDKQLY WIDSRQNMIRKAQEDGSQGFTVVVS SVPSQNLEIQPYDLSIDIYSRYIYW TCEATNVINVTRLDGRSVGV VLKGEQDRPRAIVVNPEKGYMYFTN LQERSPKIERAALDGTEREVLFFSG LSKPIALALDSRLGKLFWAD SDLRRIESSDLSGANRIVLEDSNIL QPVGLTVFENWLYWIDKQQQMIEKI DMTGREGRTKVQARIAQLSD IHAVKELNLQEYRQHPCAQDNGGCS HICLVKGDGTTRCSCPMHLVLLQDE LSCGEPPTCSPQQFTCFTGE IDCIPVAWRCDGFTECEDHSDELNC PVCSESQFQCASGQCIDGALRCNGD ANCQDKSDEKNCEVLCLIDQ FRCANGQCIGKHKKCDHNVDCSDKS DELDCYPTEEPAPQATNTVGSVIGV IVTIFVSGTVYFICQRMLCP RMKGDGETMTNDYVVHGPASVPLGY VPHPSSLSGSLPGMSRGKSMISSLS IMGGSSGPPYDRAHVTGASS SSSSSTKGTYFPAILNPPPSPATER SHYTMEFGYSSNSPSTHRSYSYRPY SYRHFAPPTTPCSTDVCDSD YAPSRRMTSVATAKGYTSDLNYDSE PVPPPPTPRSQYLSAEENYESCPPS PYTERSYSHHLYPPPPSPCT
  DSSTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Wnt signaling pathway

Gene Information

• Gene Name: LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]
• Official Symbol: LRP6
• Synonyms: ADCAD2; STHAG7
• Gene ID: 4040
• mRNA Refseq: NM_002336.3
• Protein Refseq: NP_002327.2
• MIM: 603507
• UniProt ID: O75581