lrrk2
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  • Official Full Name
  • leucine-rich repeat kinase 2
  • Background
  • This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a;leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain,;and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer;membrane. Mutations in this gene have been associated with Parkinson disease-8.
  • Synonyms
  • LRRK2; leucine-rich repeat kinase 2; PARK8, Parkinson disease (autosomal dominant) 8; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN
Cat.#:LRRK2-4634HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LRRK2 Protein, GST-tagged
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Cat.#:LRRK2-108HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LRRK2 (G2019S), GST-tagged, Active
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Cat.#:LRRK2-109HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LRRK2 (G2385R), GST-tagged, Active
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Cat.#:LRRK2-110HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LRRK2 (I2020T), GST-tagged, Active
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Cat.#:LRRK2-111HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (D1994A) Protein, GST-tagged, Active
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Cat.#:LRRK2-112HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (R1441C) Protein, GST-tagged, Active
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Cat.#:LRRK2-113HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (R1441G) Protein, GST-tagged, Active
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Cat.#:LRRK2-114HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (R1441H) Protein, GST-tagged, Active
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Cat.#:LRRK2-115HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (Y1699C) Protein, GST-tagged, Active
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Cat.#:LRRK2-116HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 (Y1699G) Protein, GST-tagged, Active
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Cat.#:LRRK2-117HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LRRK2 Protein, GST-tagged, Active
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Cat.#:LRRK2-1553HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LRRK2 protein, His-tagged
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Cat.#:LRRK2-33HTag:FLAG
Source (Host):Mammalian cellsSpecies:Human
Product nameRecombinant Human LRRK2 Protein, FLAG-tagged
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Cat.#:LRRK2-35HCLTag:Myc/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LRRK2 HEK293T cell lysate
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Cat.#:Lrrk2-1555MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lrrk2 protein, His & GST-tagged
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Involved Pathway

LRRK2 involved in several pathways and played different roles in them. We selected most pathways LRRK2 participated on our site, such as MAPK signaling pathway, Parkinsons disease, Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MKNK1; MAP3K11; AKT1; PPP3CCA; JIP1; CACNG2A; FGFR1A; NFKB2; NFATC3; TGFBR1
Parkinsons disease
COX8C; GNAL; NDUFB3; NDUFA2; Atp5g2; UQCRH; SLC6A3; VDAC1; ATP5C1; ATP5J
Parkinsons Disease Pathway
ATXN2; PARK7; UBE2J2; SYT11; LRRK2
Wnt Signaling Pathway and Pluripotency
FBXW2; PPM1J; ZBTB33; FOXD3; LRRK2

Protein Function

LRRK2 has several biochemical functions, for example, ATP binding, GTP binding, GTP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRRK2 itself. We selected most functions LRRK2 had, and list some proteins which have the same functions with LRRK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RPS6KA3B; SLK; RPS6KA3A; RAD51D; SMC1A; TEX14; SGK2A; NAIP1; KARS; LYN
Function GTP binding
Related Protein OLA1; TUBA8L2; LANCL2; RHOF; NUDT2; TUBA3E; LGALS6; GNAL; ARL11; RAB8A
Function GTP-dependent protein kinase activity
Related Protein ALPK2; LRRK2
Function GTPase activator activity
Related Protein RGS3A; GDI1; TBC1D8; ARHGAP6; EVI5; ARHGAP4; BAI3; RGS9A; RGS16; WNT11
Function GTPase activity
Related Protein GSPT2; RAC2; EEF1A1L2; RAB5B; RAB39BA; RAB17; TUBA4L; RABL5; TRIM23; RAB32
Function MAP kinase kinase activity
Related Protein MAP2K2B; SBK3; MAP2K1; MAP3K14; MAP2K3; MAP2K2A; MAP3K20; MAPK14; PAK3; MAP2K7
Function Rho GTPase binding
Related Protein ROCK2A; FMNL2; PARD6A; DIAP1; ARHGEF2; FLNA; ECT2; ANTXR2A; DAAM1; KIF3B
Function SNARE binding
Related Protein STXBP1; STX1B; YKT6; STX2; STX4A; TNFAIP2; EXOC3L4; SEC22A; VTI1A; MYO5A
Function actin binding
Related Protein KLHL1; MYOT; MTSS1L; LMOD2; MICAL2B; MYH1E; MYO1F; KIF18A; PACRG; SHROOM2
Function beta-catenin destruction complex binding
Related Protein LRRK2
Function clathrin binding
Related Protein PICALMB; DOC2B; HIP1R; SYT7B; SYTL4; SYT5B; SYT11; AP2B1; LDLRAP1; SYT15
Function glycoprotein binding
Related Protein SELP; STX1A; CALR; RGMA; APOH; ITGA3; CNTN1; RASA1; EDEM2; PLAT
Function identical protein binding
Related Protein HAND1; PCM1; HSPB8; GLE1; TTC32; ATG16L1; PAK2; PTPRG; FKBP8; LUC7L
Function ion channel binding
Related Protein RYR2; PANX1; CTNNB1; AASS; FKBP1A; BAK1; ACTN3; TCAP; PKD1; KCNH1
Function kinase activity
Related Protein NIM1; SRC; PRKAR2AA; ACVR2AA; CAMK1GA; PLK2B; MTOR; PRKCBP1L; PLK1; CDKL5
Function peroxidase inhibitor activity
Related Protein LRRK2
Function protein binding
Related Protein DNAI2; ZFP36L1; GAGE8; CRIPT; NFIX; CHGB; LRPPRC; ZNF3; PTPMT1; HSPB6
Function protein homodimerization activity
Related Protein DMRT1; ALDH1A3; RCHY1; NKX2; IDE; HM13; CHMP4C; ERBB3; ID1; PDZD7
Function protein kinase A binding
Related Protein DACT1; MYRIP; DACT3; AKAP4; AKAP12; AKAP12B; AKAP6; LRRK2; AKAP7; AKAP17A
Function protein kinase activity
Related Protein PRKG1A; MAP2K2B; COL4A3BP; LMTK3; KSR1; IGF1RB; PRKCZ; STK25B; PTK2AA; EPHB3A
Function protein serine/threonine kinase activity
Related Protein CDC42BPG; STK10; PRKACBA; RPS6KA3A; MAPK1; TAF1L; MAP3K11; ULK3; PAK7; SGK2B
Function receptor signaling complex scaffold activity
Related Protein RGS14; CARD10; LRRK2; ROPN1B; SPAG9; CD3E; NCK1; G3BP2; MAPK8IP3; SPAG9A
Function syntaxin-1 binding
Related Protein STXBP2; SNAP25; SYT1; RNF40; UNC13A; VAMP2; SNPH; SNAP25A; CPLX1; MYO5A
Function tubulin binding
Related Protein STMN4L; CENPJ; MAP1S; ATF5; VBP1; RITA1; NCALD; STMN3; AGBL4; STMN2A

Interacting Protein

LRRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRRK2.
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LRRK2 Related Articles

West, AB; Cowell, RM; et al. Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents. JOURNAL OF COMPARATIVE NEUROLOGY 522:2465-2480(2014).
Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).