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MAML1

Official Full Name

mastermind-like 1 (Drosophila)
Overview

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Synonyms

MAML1; mastermind-like 1 (Drosophila); Mam1; Mam-1; mastermind-like protein 1; mastermind homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
MYC
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MAML1-3627H	Recombinant Human MAML1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	MAML1-330H	Recombinant Human MAML1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	MAML1-1127HFL	Recombinant Full Length Human MAML1 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	MAML1-1349H	Recombinant Human MAML1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	MAML1-1349H-B	Recombinant Human MAML1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	MAML1-9475M	Recombinant Mouse MAML1 Protein	Mammalian Cell	His	Inquiry
Mouse	MAML1-5310M-B	Recombinant Mouse MAML1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	MAML1-5310M	Recombinant Mouse MAML1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Maml1-238M	Recombinant Mouse Maml1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAML1 Related Signal Pathway

MAML1 involved in several pathways and played different roles in them. We selected most pathways MAML1 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAML1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Notch signaling pathway	DVL1B;NOTCH3;NOTCH1B;SNW1;DLL1;JAG2B;PSEN1;MAML2;DLC

MAML1 has several biochemical functions, for example, peptide antigen binding, protein kinase binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAML1 itself. We selected most functions MAML1 had, and list some proteins which have the same functions with MAML1. You can find most of the proteins on our site.

Function	Related Protein
peptide antigen binding	MHC1ZHA;MHC1ZKA;HLA-DRA;MHC1UIA;MHC1UXA2;H2-Q10;HLA-G;TUBB3;H2-AB1
protein kinase binding	CCNYL1;CCNE2;PPP1R15A;CCND2;CHEK2;WAS;GPRC5B;STAP1;MAPK6
transcription coactivator activity	GABPA;MTF1;COPS5;CCNE1;FHL2;ENY2;STIL;NACA;VGLL1

MAML1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAML1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAML1.

Notch1