Recombinant Full Length Human MAML1 Protein, C-Flag-tagged

• Cat.No.: MAML1-1127HFL
• Product Overview: Recombinant Full Length Human MAML1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 107.9 kDa
• AA Sequence: MVLPTCPMAEFALPRHSAVMERLRR RIELCRRHHSTCEARYEAVSPERLE LERQHTFALHQRCIQAKAKR AGKHRQPPAATAPAPAAPAPRLDAA DGPEHGRPATHLHDTVKRNLDSATS PQNGDQQNGYGDLFPGHKKT RREAPLGVAISSNGLPPASPLGQSD KPSGADALQSSGKHSLGLDSLNKKR LADSSLHLNGGSNPSESFPL SLNKELKQEPVEDLPCMITGTVGSI SQSNLMPDLNLNEQEWKELIEELNR SVPDEDMKDLFNEDFEEKKD PESSGSATQTPLAQDINIKTEFSPA AFEQEQLGSPQVRAGSAGQTFLGPS SAPVSTDSPSLGGSQTLFHT SGQPRADNPSPNLMPASAQAQNAQR ALAGVVLPSQGPGGASELSSAHQLQ QIAAKQKREQMLQNPQQATP APAPGQMSTWQQTGPSHSSLDVPYP MEKPASPSSYKQDFTNSKLLMMPSV NKSSPRPGGPYLQPSHVNLL SHQPPSNLNQNSANNQGSVLDYGNT KPLSHYKADCGQGSPGSGQSKPALM AYLPQQLSHISHEQNSLFLM KPKPGNMPFRSLVPPGQEQNPSSVP VQAQATSVGTQPPAVSVASSHNSSP YLSSQQQAAVMKQHQLLLDQ QKQREQQQKHLQQQQFLQRQQHLLA EQEKQQFQRHLTRPPPQYQDPTQGS FPQQVGQFTGSSAAVPGMNT LGPSNSSCPRVFPQAGNLMPMGPGH ASVSSLPTNSGQQDRGVAQFPGSQN MPQSSLYGMASGITQIVAQP PPQATNGHAHIPRQTNVGQNTSVSA AYGQNSLGSSGLSQQHNKGTLNPGL TKPPVPRVSPAMGGQNSSWQ HQGMPNLSGQTPGNSNVSPFTAASS FHMQQQAHLKMSSPQFSQAVPNRPM APMSSAAAVGSLLPPVSAQQ RTSAPAPAPPPTAPQQGLPGLSPAG PELGAFSQSPASQMGGRAGLHCTQA YPVRTAGQELPFAYSGQPGG
  SGLSSVAGHTDLIDSLLKNRTSEEW MSDLDDLLGSQTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Notch signaling pathway

Gene Information

• Gene Name: MAML1 mastermind like transcriptional coactivator 1 [ Homo sapiens (human) ]
• Official Symbol: MAML1
• Synonyms: Mam1; Mam-1
• Gene ID: 9794
• mRNA Refseq: NM_014757.5
• Protein Refseq: NP_055572.1
• MIM: 605424
• UniProt ID: Q92585