map2k1
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  • Official Full Name
  • mitogen-activated protein kinase kinase 1
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Cat.#:MAP2K1-175HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1, GST-tagged
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Cat.#:MAP2K1-167HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human v protein, MYC/DDK-tagged
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Cat.#:MAP2K1-2568HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
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Cat.#:MAP2K1-299HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
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Cat.#:MAP2K1-300HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His/MBP-tagged
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Cat.#:MAP2K1-343HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAP2K1
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Cat.#:MAP2K1-596HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP2K1, His-tagged
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Cat.#:MAP2K1-62HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MAP2K1 protein, Flag-tagged, Biotinylated
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Cat.#:MAP2K1-639HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K1 protein, His-tagged
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Cat.#:Map2k1-1032MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1 protein, GST-tagged
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Cat.#:Map2k1-1350MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Map2k1, His & GST tagged
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Cat.#:MAP2K1-483MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1, Gly & Pro tagged
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Cat.#:Map2k1-666MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k1, GST-tagged
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Cat.#:MAP2K1-3559RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP2K1 Protein
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Cat.#:MAP2K1-2663RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K1 Protein, His-tagged
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Cat.#:MAP2K1-1266CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K1
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Cat.#:MAP2K1-12591ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP2K1
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Cat.#:MAP2K1-1033HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-1034HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-1035HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged
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Cat.#:Map2k1-1032HTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged
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Cat.#:MAP2K1-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K1 cell lysate
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Cat.#:Kit-1614Tag:N/A
Source (Host):Species:
Product nameMEK1 Kinase Binding Assay Kit
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Involved Pathway

Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TAOK3; MAPK8; PLA2G4F; PRKACB; Pdgfa&Pdgfb; PDGFRB; DUSP8A; RAF1; FGF10; MAP4K3
ErbB signaling pathway
PRKCA; HBEGFA; PLCG2; CBLB; ERBB3A; GRB2; SRC; PIK3R3B; MAP2K4; MAP2K2
Ras signaling pathway
PLA2G10; MLLT4; RGL2; GNB4; RAC2; RAC3; PDGFC; SHC1; NRAS; FGF5
Rap signaling pathway
CALML3; PIK3R3; FGF17; FGF4; GRIN2A; PIK3R2; PDGFC; GRIN1; FGF13; KITLG
cGMP-PKG signaling pathway
PRKG2; ATP1A2; BDKRB2; PLCB4; MEF2A; PRKG1; VDAC1; PIK3CB; PDE3B; SRF
cAMP signaling pathway
SUCNR1; LOC100328615; PIK3CB; GRIN3A; NFATC1; NPY; MAPK9; SOX9; PPARA; MAPK10
Chemokine signaling pathway
CCL4; KRAS; GM13306; CCL17; Ccl27a; CCL11; RELA; CRKL; JAK2; GM13304
HIF- signaling pathway
RPS6; INS; NOX1; CUL2; EPO; PIK3R2; EP300; PLCG1; FLT1; LDHA
FoxO signaling pathway
RAF1A; AKT2; IL6; SMAD4; PIK3R2; G6PCA.1; ATM; PRKAG2; MAPK12; PRKAG1
Sphingolipid signaling pathway
GAB2; PTEN; SGMS2; S1PR2; PIK3CG; GNAI3; PIK3R2; PLCB4; BCL2; MAPK12
Phospholipase D signaling pathway
RRAS; FCER1G; RALB; Kitl; LPAR5; MRAS; GRM5; PRKCA; PPAP2B; PIK3R5
Oocyte meiosis
CDC16; CPEB4; CAMK2D; MAD2L2; CPEB2; PPP2R5E; CUL1; YWHAE; ANAPC2; PPP3R2
PIK-Akt signaling pathway
KIT; TLR4; GNG5; Il6ra; LAMA1; INSR; PRKAA1; MTCP1; GHR; GRB2
Vascular smooth muscle contraction
CYP4A10; MAP2K2A; PLA2G12A; PPP1CBL; CYP4A12A; PLA2G10; GNA13A; AVPR1A; CACNA1SB; MAP2K2
Dorso-ventral axis formation
NOTCH4; CPEB1B; PIWIL1; CPEB1; PIWIL2; SOS1; PPP1R2P9; EGFRA; NOTCH1; CPEB2
VEGF signaling pathway
PLA2G4AA; AKT2L; PTK2; PPP3CC; PIK3R1; MAP2K2A; AKT3A; MAPK1; PPP3CB; RAF1A
Osteoclast differentiation
IL1A; LILRB3; MAPK11; NFKB2; MAPK12; MAP2K1; MAPK3; IFNGR1; TNF; GAB2
Focal adhesion
TNC; MAPK8B; ILK; COL6A5; AKT3A; PRKCBB; PRKCA; COMP; PIK3R2; COL1A1B
Gap junction
GNAS; MAPK3; PRKCA; TUBB2A; TUBA3E; GNAI1; TUBA4A; TUBA1C; TUBB2B; PRKACAA
Signaling pathways regulating pluripotency of stem cells
RAF1; WNT9B; NANOG; PCGF3; SMAD5; HNF1A; TCF3; PIK3CG; HESX1; PCGF6
Toll-like receptor signaling pathway
TLR4BB; PIK3CB; PIK3R2; TLR2-2; TLR4; CCL4L1; TBK1; CCL3L1; IFNA2; MAP2K2A
Natural killer cell mediated cytotoxicity
RAET1L; IFNGR1; PPP3CC; RAC3; FAS; CD244; KIR2DL3; Ifna15; KLRC3; ARAF
T cell receptor signaling pathway
PPP3R1; PTPN6; MAP3K7; MUC1; MAPK12; DLG1; FOS; NCK2; PAK6; RAF1
B cell receptor signaling pathway
PIK3AP1; MALT1; CD19; MAP4K1; NFATC3; NFATC2; DUSP6; KRAS; CD81; NFKB1
Fc epsilon RI signaling pathway
BTK; MAPK1; MAP2K4; MAP2K1; PIK3R2; PIK3CA; PIK3R5; SYK; RAC3; MAPK12
Fc gamma R-mediated phagocytosis
ASAP2; WAS; AMPH; PRKCD; WASF2; cgr2b; ARPC5L; SPHK2; RAC2; PPAP2A
TNF signaling pathway
MMP3; CASP7; MAP2K6; VCAM1; MAP3K7IP3; RIPK1; TRAF3; VEGFC; MAPK10; FAS
Long-term potentiation
HRAS; PRKCG; ATF4; RPS6KA6; GNAQ; ARAF; PLCB1; CALM3; PLCB2; GRM1
Neurotrophin signaling pathway
IRAK4; RIPK2; PIK3CA; FOXO3; NFKBIA; ABL1; MAGED1; FASLG; SOS1; YWHAE
Cholinergic synapse
GNGT1; AKT1; AKT2; CHRNA7; CHRNA4; CHRNA6; GNG4; CHAT; BCL2; GNG7
Serotonergic synapse
CYP2D9; NRAS; PRKACB; HTR7; GNG8; MAPK1; CYP2C39; GNG5; PRKCG; GNB1
Long-term depression
PRKCG; GNA11; RAF1; NRAS; PLA2G4A; HRAS; LYN; BRAF; GNAI1; GNA13
Regulation of actin cytoskeleton
ITGAE; FGF17; FGF10A; RHOAB; PIK3R3A; ITGA8; INS; ITGA3; PXN; FGF5
Insulin signaling pathway
MKNK1; G6PCA.2; GYS2; SREBF1; INPPL1; PRKAG2A; G6PC2; PPP1CBL; IKBKB; HRAS
GnRH signaling pathway
PRKCA; MAP3K2; CALM2A; MMP14B; CALML5; MAPK3; MAPK11; RAF1A; MAP2K2A; CAMK2G
Progesterone-mediated oocyte maturation
CDK1; MAPK13; IGF1RB; ARAF; CPEB1A; PIK3CA; ADCY1B; ANAPC2; MAPK12B; RPS6KA6
Estrogen signaling pathway
GPR30; HSPA1A; MAPK3; CREB5; CALM2; CREB3L3; ITPR1; MAP2K2; CREB3L2; HRAS
Melanogenesis
WNT2; WNT4A; GNAI2B; ASIP; WNT8B; DVL3A; KITLG; PRKACAA; PLCB1; FZD8
Prolactin signaling pathway
GSK3B; ELF5; FOS; STAT3; SOCS2; FOXO3; PIK3CD; CSN2; ESR2; NRAS
Thyroid hormone signaling pathway
FOXO1; NOTCH1; MED24; NCOR1; ATP1B1; PIK3R2; MED27; MDM2; ITGAV; NRAS
Oxytocin signaling pathway
CALM2; CACNG7; CAMK1; MAPK7; CACNA2D2; CALM3; KCNJ14; NOS3; PIK3R5; RGS2
Prion diseases
C6; PRKACG; SOD1; C1QC; HSPA1A; LAMC1; CASP12; MAPK1; NOTCH1; IL1B
Alcoholism
KRAS; H2AFY; CALML5; HIST1H3A; HIST3H3; CALM4; NTRK2; GNG13; HIST1H2BP; HDAC9
Hepatitis B
HBXIP; BAD; STAT3; TICAM2; STAT4; PTK2B; CCND1; MAP2K4; IFNA4; IFNA21
Influenza A
PIK3CG; TNFRSF1A; HLA-DQA1; TRIM25; ADAR; IFNGR2; KPNA1; SOCS3; CYCS; IFNA21
Pathways in cancer
PIK3R5; GNB4; HDAC2; RAF1; CCND1; FH; WNT7B; GNGT1; ERBB2; LPAR4
Proteoglycans in cancer
FGF2; MAPK12; WNT5A; PLAUR; PRKACA; PIK3R2; CAV2; ARHGEF12; PRKACB; HPSE2
MicroRNAs in cancer
Casp3; CCND1; NOTCH4; RDX; DNMT3A; RASSF1; APC; IRS1; HDAC4; EZH2
Colorectal cancer
BIRC5; PIK3CG; TGFB2; PIK3R5; TGFBR2; KRAS; RAF1; AKT1; PIK3R1; RAC2
Renal cell carcinoma
RAF1; HGF; ARNT; RAC1; MAP2K1; GRB2; PAK2; PDGFB; EGLN1; TCEB2
Pancreatic cancer
VEGFA; AKT1; BRAF; RAC1; ERBB2; NFKB1; IKBKG; TGFB3; RALB; TGFA
Endometrial cancer
AXIN2; LEF1; BAD; APC2; PTEN; MLH1; PIK3CA; KRAS; MAPK3; ARAF
Glioma
PTEN; TRP53; KRAS; MAP2K1; CALM1; NRAS; PDGFRA; AKT2; SHC1; RAF1
Prostate cancer
CREB3L1; GSTP1; FGFR2; SPINK1; ARAF; ERBB2; PDGFA; GRB2; NKX3; NOXA1
Thyroid cancer
BRAF; TCF7L2; MAP2K2; MAP2K1; CCND1; KRAS; PAX8; NRAS; RET; TP53
Melanoma
FGF9; FGF4; AKT2; PDGFB; CCND1; RB1; HGF; MAPK1; PIK3R1; PDGFD
Bladder cancer
E2F3; TRP53; E2F2; HRAS; CXCL8; TYMP; DAPK2; RPS6KA5; EGF; VEGFA
Chronic myeloid leukemia
TRP53; PTPN11; PIK3CA; MAPK3; GAB2; RELA; CCND1; PIK3CG; PIK3CB; CBL
Acute myeloid leukemia
MTOR; MYC; CEBPA; RPS6KB1; PIK3R2; PIK3CA; PIK3R3; NRAS; PIK3R5; FLT3
Non-small cell lung cancer
RASSF5; MAPK3; AKT1; TP53; RASSF1; KRAS; CCND1; TGFA; PIK3CG; PIK3CB
Central carbon metabolism in cancer
SLC2A1; PDHB; KRAS; MAPK3; NRAS; HK1; PIK3R3; SCO2; MAPK1; PIK3CG
Choline metabolism in cancer
PIP5K1C; SLC22A2; TSC2; GPCPD1; PPAP2C; PRKCA; DGKB; PIK3CD; RAC3; PLD1

Protein Function

Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein LIG4; GSK3A; ABCD3; ABCD4; QARS; FYNA; NTRK2B; DDX49; PPIP5K2; PANK2
Function MAP kinase kinase activity
Related Protein ALPK2; MAP3K9; MAP2K2; MAP2K7; MAPK10; MAP3K14; MAP3K20; MAP2K3; MAPK14; MAP2K2A
Function Ras GTPase binding
Related Protein MLLT4; RGL3; RASGRP3; RIN1; PLCE1; RAP1A; MAP2K1; MAPKAP1; RAP1GAP; CIB1
Function mitogen-activated protein kinase kinase kinase binding
Related Protein CDC37; MAP2K1; MAP4K2; MAPK1; TRAF6; MARVELD3; DUSP19; TCF3; MAPK8IP3; TRAF2
Function protein C-terminus binding
Related Protein EP300; KCNIP3; PHB; ITGB3BP; CSK; VGLL2; SLC4A1; XRCC6; HESX1; PROP1
Function protein N-terminus binding
Related Protein BIRC2; NIPBL; GLRX; DCN; VWF; FEZ1; TDRD7; ID1; SCFD1; RASSF1
Function protein binding
Related Protein TSEN54; MTMR6; ILKAP; SEMA7A; CCR1; RAB11B; FAM46B; FABP2; SOCS3; CDC23
Function protein kinase activity
Related Protein CLK2A; CCL3; STK3; NEK10; TNNI3K; PTK2BB; GSK3AA; PRKAG1; NPR1A; GM4922
Function protein serine/threonine kinase activator activity
Related Protein STRADA; IGF2; STK4; CALM1; SPRY2; STK3; CAB39; PARP16; ALS2; CALM3
Function protein serine/threonine kinase activity
Related Protein MARK4; DSTYK; PDK3; ADCK1; TTK; CLK4; TAF1L; SGK2; MYLK4; SNRKA
Function protein serine/threonine/tyrosine kinase activity
Related Protein CLK3; CLK1; RPS6KA1; AKT1; ACVR2B; DYRK1AA; SGK1; CLK2; TESK1; DYRK1B
Function protein tyrosine kinase activity
Related Protein CLK3; LCK; INSRB; PTK6B; TYRO3; MET; ABL2; JAK2B; CSK; EPHA4A
Function receptor signaling protein tyrosine phosphatase activity
Related Protein MAP2K1

Interacting Protein

Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.
BRAF