MAP3K7 Protein, mitogen-activated protein kinase kinase kinase 7


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Official Full Name mitogen-activated protein kinase kinase kinase 7
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; MAP; MAP3K; mitogen-activated protein kinase 7
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K7-1056HCL Recombinant Human MAP3K7 cell lysate N/A
    Human MAP3K7-30308TH Recombinant Human Human MAP3K7 N/A
    Human MAP3K7-82H Recombinant Human MAP3K7 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TAK1-TAB1-440H Recombinant Human TAK1-TAB1, GST-tagged, Active Sf9 Insect Cell GST
    Rat MAP3K7-3566R Recombinant Rat MAP3K7 Protein Mammalian Cell His
    Zebrafish MAP3K7-2890Z Recombinant Zebrafish MAP3K7 Mammalian Cell His

    MAP3K7 involved in several pathways and played different roles in them. We selected most pathways MAP3K7 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway SYK; CD40; MYD88; VCAM1; GADD45B; MAP3K14; LCK; CCL13; TNFSF13B; TNFRSF13C
    AMPK signaling pathway CREB3L4; PIK3CD; MAP3K7; PPP2R5D; STK11; CREB1; PIK3R5; PFKFB1; G6PC; PIK3CB
    Wnt signaling pathway WNT16; PPP3R2; RAC3A; RHOAA; PRICKLE1; PORCNL; PPP3CCB; FBXW11B; WNT2BA; WNT7AA
    Osteoclast differentiation PPP3CC; LILRA3; BTK; PPP3R2; CYBA; TGFBR1; PPP3R1; SYK; NCF2; MAPK11
    Adherens junction RHOA; PARD3; SNAI2; LMO7; RAC1B; TGFBR1A; WASF1; ACTB; PTPRFB; CSNK2A1
    Toll-like receptor signaling pathway IL12B; TLR9; IFNB; CXCL11; MAP2K4B; LBP; MAP2K1; TLR1LA; CCL3; TICAM2
    NOD-like receptor signaling pathway MAPK8; NFKBIB; MAPK14B; HSP90B1; PSTPIP1B; HSP90AB1; CXCL8B.3; SUGT1; HSP90AA1.1; CARD8
    RIG-I-like receptor signaling pathway IKBKG; IRF7; OTUD5A; TRAF3; IFNA10; TRAF2; CASP8; IFNA14; OTUD5; MAP3K1
    T cell receptor signaling pathway BCL10; FOS; CD4; PRKCQ; PAK1; DLG1; MAP2K7; PAK3; TEC; PTPN6
    TNF signaling pathway TRAF3; MAPK9; PIK3CA; PIK3R5; MAP2K3; CXCL3; IKBKG; CXCL1; MAPK1; DNM1L
    Leishmaniasis IL4; IFNG; FCGR4; C3; HLA-DMB; MAPK13; NOS2; FCGR2A; TLR2; IL1A
    Toxoplasmosis TLR4; HLA-DMB; IRAK4; HLA-DRB4; HSPA1A; PPIF; HSPA6; BIRC7; LDLR; Toxoplasma Gondii Microneme Protein MIC3
    Measles IRAK1; PIK3R5; DDX58; MAVS; Fasl; IL12A; IRF7; OAS2; PIK3CA; TNFRSF10B
    Herpes simplex infection CASP3B; IFNA10; IFNG; IFNA13; RNASEL; CDC34A; C5; TLR2; BMA1; MAVS
    Epstein-Barr virus infection HDAC5; NFKBIE; MAP3K14; PTMA; TRP53; IKBKB; CD58; LYN; ITGAL; CD38

    MAP3K7 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K7 itself. We selected most functions MAP3K7 had, and list some proteins which have the same functions with MAP3K7. You can find most of the proteins on our site.

    Function Related Protein
    protein C-terminus binding HESX1; SNF8; VPS4B; ERCC6; TOP2B; MAP3K7; PPM1A; SIAH1; VPS36; PEX26
    protein binding JAM3; MKRN1; HPN; AK8; UBE2IB; SPTBN1; NFS1; C10orf62; IL5; LRFN4
    protein heterodimerization activity H2AFX; HIST1H2AG; GABPB1; RRAGC; GCA; TAF9; HIST2H2BE; BMP2B; ENO3; KCNH5
    transcription cofactor activity ZMYND11; ZNF865; TAF13; LDB2B; ANKRA2; WDR75; ZFP710; PIR; TADA2A; MED12
    transcription factor activity, sequence-specific DNA binding SREBF1; HSFX1; HMGB2; HOXC8; MYCN; ETV1; HNF1B; JUN; MYRFL; EGR2

    MAP3K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K7.


    Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
    Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).

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