map3k7
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 7
  • Background
  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; MAP; MAP3K; mitogen-activated protein kinase 7
Cat.#:MAP3K7-30308THTag:
Source (Host):Species:Human
Product nameRecombinant Human Human MAP3K7
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Cat.#:MAP3K7-82HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MAP3K7 protein, Flag-tagged, Biotinylated
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Cat.#:MAP3K7-3566RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP3K7 Protein
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Cat.#:MAP3K7-2890ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAP3K7
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Cat.#:TAK1-TAB1-440HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TAK1-TAB1, GST-tagged, Active
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Cat.#:MAP3K7-1056HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K7 cell lysate
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Involved Pathway

MAP3K7 involved in several pathways and played different roles in them. We selected most pathways MAP3K7 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ARR3A; PDGFA; MAPK8; MAP2K4B; RPS6KA3A; ZAK; STMN1; CACNG2A; NR4A1; PLA2G4C
NF-kappa B signaling pathway
MAP3K7; PLCG2; UBE2I; DDX58; TNFSF13B; CCL13; GADD45B; CXCL12; LBP; BCL2A1
AMPK signaling pathway
PRKAB1; RAB14; EEF2; MLYCD; PPP2R5D; PRKAA2; PPP2R2C; PPP2R5B; PPP2CA; INSR
Wnt signaling pathway
RBX1; EP300; SFRP2; SKP1; PSEN1; PLCB2; PLCB3; PRKCB; Fzd4; BTRC
Osteoclast differentiation
SOCS1; PPP3R2; IFNAR2; SIRPA; ACP5; MAPK10; SYK; LCK; CYLD; FCGR3A
Adherens junction
FYN; RAC3; WASB; Fert2; WASLA; WASLB; TGFBR1A; CDH1; FER; NLK2
Toll-like receptor signaling pathway
CASP8; TLR5B; IFNA3; RAC1; MAPK12A; CD40; CD14; CD80; MAPK1; AKT2
NOD-like receptor signaling pathway
MAPK8; CARD18; CCL5; SGUT1; MAPK11; MAPK8B; PSTPIP1A; CXCL1; TRAF6; CASP8
RIG-I-like receptor signaling pathway
RIPK1; NLRX1; TMEM173; PIN1; Ifna15; MAPK10; DHX58; MAP3K1; IFIH1; IFNA10
T cell receptor signaling pathway
PDPK1; CD3G; NFKBIA; NRAS; NCK1; MUC1; IKBKG; SOS1; NFKBIB; CABIN1
TNF signaling pathway
VEGFC; MAP2K1; BAG4; IL1B; VCAM1; CREB5; BCL3; PIK3R2; CASP8; IL18R1
Leishmaniasis
TGFB3; TLR4; FOS; HLA-DMA; HLA-DRB5; HLA-DPB1; CR1; HLA-DQB1; MYD88; MAPK12
Toxoplasmosis
TRAF6; TGFB2; LAMA5; LAMA3; PIK3R2; MAPK12; MAPK3; IRGM1; TGFB1; XIAP
Measles
PIK3CD; TNFAIP3; CD209; IFNA8; IFIH1; TNFRSF10B; EIF2AK4; MAVS; IFNA2; TLR4
Herpes simplex infection
SRSF2; SRSF7; EEF1D; SRSF6; OAS2; MHC1UEA; BMA1; PVRL2; NFKB1; MAPK9
Epstein-Barr virus infection
DDX58; PSMD8; POLR2B; POLR2K; POLR3C; CD40; SPI1; POLR2G; EIF2AK3; HLA-DPA1

Protein Function

MAP3K7 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K7 itself. We selected most functions MAP3K7 had, and list some proteins which have the same functions with MAP3K7. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein THAP2; AIFM1; JUNBB; UBTFL1; SPHK1; KLF9; HMX4; PURG; TDP2B; PPARD
Function protein C-terminus binding
Related Protein RBFOX1; MAP3K7; TERF2; PROP1; SNX17; YWHAB; XRCC5; PEX12; PEX10; HOMER3
Function protein binding
Related Protein VAV1; JAKMIP1; POLE3; MCM6; FUNDC1; CALD1; FAM158A; SWAP70; ZNF79; CTSK
Function protein heterodimerization activity
Related Protein BMP7A; GUCY1A3; SOX15; HIST1H4G; GABPA; PVALB; RALGAPA2; IKZF2; GAD2; SRY
Function transcription cofactor activity
Related Protein PSMC5; MED30; ANKRA2; MED12; NMI; MED16; ZNF865; LDB1A; MSX2; ZMYND11
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXB6; STAT1A; CNOT8; ZFP746; FOXP1B; TFDP2; DLX4; ZNF500; HOXB6B; RFX8

Interacting Protein

MAP3K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K7.
TAB2; MAPK8IP1; MAP2K7; TRAF6

MAP3K7 Related Articles

Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).