mapk14
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  • Official Full Name
  • mitogen-activated protein kinase 14
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein;
Cat.#:MAPK14-382HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPK14 Protein, MYC/DDK-tagged
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Cat.#:MAPK14-142HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK14, His tagged
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Cat.#:MAPK14-177HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14, Active, His-tagged
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Cat.#:MAPK14-178HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14, Inactive, His-tagged
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Cat.#:MAPK14-25HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14, GST-tagged, Unactive
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Cat.#:MAPK14-26HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14, Unactive
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Cat.#:MAPK14-27HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14(K53A), His-tagged, Unactive
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Cat.#:MAPK14-30539THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14
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Cat.#:MAPK14-314HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14 protein, His/MBP-tagged
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Cat.#:MAPK14-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK14, His-tagged
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Cat.#:MAPK14-356HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK14 protein, His-tagged
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Cat.#:MAPK14-474HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAPK14
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Cat.#:MAPK14-50HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK14 protein
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Cat.#:MAPK14-550HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human MAPK14, His-tagged
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Cat.#:MAPK14-599HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human MAPK14, GST-tagged
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Cat.#:MAPK14-618HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK14, Fc tagged
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Cat.#:MAPK14-67HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MAPK14 protein, Flag-tagged, Biotinylated
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Cat.#:MAPK14-9530MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK14 Protein
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Cat.#:MAPK14-5307HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 14, His-tagged
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Cat.#:MAPK14-372HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK14, GST-tagged, Active
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Cat.#:MAPK14-1046HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 14, GST-tagged
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Cat.#:MAPK14-1047HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 14
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Cat.#:MAPK14-1344HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 14, His-tagged
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Cat.#:MAPK14-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK14 cell lysate
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Involved Pathway

MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1, AGE/RAGE pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ADP signalling through P2Y purinoceptor 1
MAPK14; GNB5
AGE/RAGE pathway
DDOST; JAK2; JUN; TIRAP; EGFR; CHUK; MMP13; AGER; DIAPH1; MAPK14
ATF-2 transcription factor network
CREB1; GADD45A; CDK4; JUN; JDP2; KAT5; POU2F1; ATF2; JUND; KCNA3
Activated TLR4 signalling
S100B; DUSP3B; CREB1; DUSP6; DUSP7; NOD1; APPB; S100A12; DHX9; MAPK14
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
MAPK14
Activation of the AP-1 family of transcription factors
ATF2; MAPK14; JUN
Adrenergic signaling in cardiomyocytes
ACTC1A; ATP1B4; CAMK2A; ATP1B3; CACNA1SB; TNNT2; PPP2R5B; AKT1; CACNA2D2; PPP2R2D
Amyotrophic lateral sclerosis (ALS)
GRIA1; BAX; CASP9; CASP12; TNFRSF1B; GRIN1; ALS2; TOMM40; PRPH; GRIN2C

Protein Function

MAPK14 has several biochemical functions, for example, ATP binding, MAP kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MVDA; PRKDC; MAP2K2B; RAD17; CDK2; CDC34A; RUNX2B; SMARCAL1; KIF18B; STK40
Function MAP kinase activity
Related Protein MAPK15; NLK2; MAPK6; MAPK12A; MAPK14A; NLK; MAPK3; MAPK12B; MAPK12; NLK1
Function MAP kinase kinase activity
Related Protein MAP2K7; MAP3K9; MAP3K20; MAP2K6; SBK3; PAK3; MAPK10; MAP2K3; LRRK2; MAP2K2
Function NFAT protein binding
Related Protein MAPK14; GATA4; PPARA; SFPI1; SPI1; FOXP3
Function enzyme binding
Related Protein HINFP; YES1; SRC; BIRC5; ATP6AP2; TSPAN15; PRKCE; HLCS; CAT; DYM
Function protein binding
Related Protein PRAP1; PTPN13; MAPK6; C1orf94; CENPO; PTPN4; JUNB; SGK3; SIN3A; L3MBTL3
Function protein phosphatase binding
Related Protein ROS1; VCAN; RPA3; PPP6R1; VRK3; CDH2; PPP1R3C; JAK1; MAP2K7; ERBB2
Function protein serine/threonine kinase activity
Related Protein HUNK; IRAK1; PAK6; RIPK4; CHEK2; ULK3; RAF1; AKT1; MAPK8B; MAPK11

Interacting Protein

MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.
MAPKAPK2; MAPKAPK3; SUPT20H; DUSP1

MAPK14 Related Articles

Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Li, W; Li, H; et al. Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway. BIOLOGY OF REPRODUCTION 83:481-487(2010).
Deshmukh, HS; McLachlan, A; et al. Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:834-845(2009).