mapkapk2
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  • Official Full Name
  • mitogen-activated protein kinase-activated protein kinase 2
  • Background
  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms
  • MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2; MK2; MK-2; MAPKAP-K2
Cat.#:MAPKAPK2-550HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPKAPK2 Protein, MYC/DDK-tagged
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Cat.#:MAPKAPK2-27127THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPKAPK2
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Cat.#:MAPKAPK2-27128THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPKAPK2
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Cat.#:MAPKAPK2-27129THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPKAPK2
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Cat.#:MAPKAPK2-346HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPKAPK2, His-tagged, Active
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Cat.#:MAPKAPK2-347HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPKAPK2, GST-tagged, Active
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Cat.#:MAPKAPK2-598HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human MAPKAPK2, GST-tagged
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Cat.#:MAPKAPK2-670HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPKAPK2
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Cat.#:MAPKAPK2-6987HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPKAPK2 protein, His & T7-tagged
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Cat.#:Mapkapk2-6988MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mapkapk2 protein, His & T7-tagged
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Cat.#:MAPKAPK2-9544MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPKAPK2 Protein
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Cat.#:MAPKAPK2-1426HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPKAPK2 (Active), His-tagged
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Involved Pathway

MAPKAPK2 involved in several pathways and played different roles in them. We selected most pathways MAPKAPK2 participated on our site, such as MAPK signaling pathway, VEGF signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPKAPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP4K1; PPM1AB; MAPK9; PLA2G4D; FGF17; MAPK8A; TGFBR2; RPS6KA1; MAPK3; LRRK2
VEGF signaling pathway
PTK2; RAC3B; CDC42L2; PPP3R2; CDC42L; MAPK3; CASP9; NFATC2; MAPKAPK2; RAC2
Neurotrophin signaling pathway
NTF4; BCL2; KRAS; CALM4; KIDINS220; NFKBIB; SORT1; PIK3R5; TRP53; SHC4
Viral carcinogenesis
HIST2H2BB; GSN; PXN; HIST1H2BI; RELA; CCNE1; EGR3; YWHAG; GTF2A1; SRF

Protein Function

MAPKAPK2 has several biochemical functions, for example, ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPKAPK2 itself. We selected most functions MAPKAPK2 had, and list some proteins which have the same functions with MAPKAPK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF19; STK24; CLK4B; DDX41; ATP13A1; CAMKK1A; SLC22A5; CSF1R; ATP1A2A; NME1
Function calcium-dependent protein serine/threonine kinase activity
Related Protein MKNK1; MAPKAPK2B; MKNK2; CAMK1GA; MKNK2A; MKNK2B; MAPKAPK2A; CAMK1GB; DCX; MAPKAPK2
Function calmodulin binding
Related Protein UPF3B; CAMK2A; NOS3; GM101; CAMK2G1; NRGN; EPB41; GRIN1; CAMKK1; MYH1E
Function calmodulin-dependent protein kinase activity
Related Protein CAMK2G; MAPKAPK5; CAMK2G1; CAMK2B1; MAPKAPK2B; DAPK1; MKNK2A; MYLK3; ITPKA; CAMK2A
Function mitogen-activated protein kinase binding
Related Protein ARRB2; MAPK7; MAPKAPK2B; MAPKAPK2; DUSP2; NBR1; CDK5RAP3; MAPKAPK5; SIRT1; TPR
Function protein binding
Related Protein TUFT1; ENTPD5; PBX1; ZBP1; TSC22D3; FLII; LGR6; ARFIP2; GPATCH8; CRYGD
Function protein kinase activity
Related Protein CDK11B; NLK1; Aatk; RNASEL; SYK; PLK2B; RAF1; RPS6KA3A; PRKD2; BMPR1BA
Function protein serine/threonine kinase activity
Related Protein BMPR2B; VPRBP; MAP3K9; AKT2L; PRPF4B; PLK2B; DAPK3; CSNK1D; PSKH2; TAOK2
Function signal transducer activity
Related Protein PLEKHG5; OLFR15; BCAR1; OXTRL; EXORH; OLFR491; PTK2AA; CD40; GNB1A; VMN1R41

Interacting Protein

MAPKAPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPKAPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPKAPK2.
MAPK14; HSPB1; HSF1; STAT3; saicar; ALOX5; PKM

MAPKAPK2 Related Articles

Jamesdaniel, S; Ding, DL; et al. Analysis of Cochlear Protein Profiles of Wistar, Sprague-Dawley, and Fischer 344 Rats with Normal Hearing Function. JOURNAL OF PROTEOME RESEARCH 8:3520-3528(2009).
Felix, RS; Colleoni, GWB; et al. SAGE analysis highlights the importance of p53csv, ddx5, mapkapk2 and ranbp2 to multiple myeloma tumorigenesis. CANCER LETTERS 278:41-48(2009).